Patents Assigned to KOCAK FARMA ILAC VE KIMYA SAN. A.S
  • Method for producing antifolate agents having glutamic acid part in their structure
    Patent number: 8680319
    Abstract: A method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-substituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: March 25, 2014
    Assignee: Kocak Farma Ilac ve Kimya San. A.S
    Inventors: Ender Kocak, Tuncer Aslan
  • Method for producing antifolate agents having glutamic acid part in their structure
    Publication number: 20130253192
    Abstract: A new method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-subsituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.
    Type: Application
    Filed: December 3, 2010
    Publication date: September 26, 2013
    Applicant: KOCAK FARMA ILAC VE KIMYA SAN. A.S
    Inventors: Ender Kocak, Tuncer Aslan