Patents Assigned to KOHJIN LIFE SCIENCES CO., LTD.
  • Patent number: 11771735
    Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: October 3, 2023
    Assignees: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITY
    Inventors: Takaomi Kessoku, Atsushi Nakajima, Yoshio Sumida, Yuichiro Eguchi, Susumu Saito, Yusuke Sauchi
  • Publication number: 20220072083
    Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.
    Type: Application
    Filed: November 19, 2021
    Publication date: March 10, 2022
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITY
    Inventors: Takaomi KESSOKU, Atsushi NAKAJIMA, Yoshio SUMIDA, Yuichiro EGUCHI, Susumu SAITO, Yusuke SAUCHI
  • Patent number: 11207371
    Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: December 28, 2021
    Assignees: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITY
    Inventors: Takaomi Kessoku, Atsushi Nakajima, Yoshio Sumida, Yuichiro Eguchi, Susumu Saito, Yusuke Sauchi
  • Patent number: 11058136
    Abstract: Low-salt processed foods or drinks frequently taste like something is missing because of the less salty taste thereof. Although salt substitutes and flavoring agents are often used to offer a sense of satisfaction, these additives exhibit only limited effects or cause some troubles of, for example, changing the original flavor of food. Under these circumstances, the present invention addresses the problem of enhancing the salty taste of a low-salt processed food or drink without imparting any undesired taste thereto. To solve the above problem, the present inventors conducted intensive studies and, as a result, found that an effect of comfortably and naturally enhancing salty taste can be achieved by adding a composition, which comprises dietary fibers, in particular, glucan and mannan at a specific ratio, to common processed foods or drinks including low-salt processed foods or drinks.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: July 13, 2021
    Assignee: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Yuki Saito, Yoshie Yasumatsu, Kenichi Ason
  • Publication number: 20200289605
    Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITY
    Inventors: Takaomi KESSOKU, Atsushi NAKAJIMA, Yoshio SUMIDA, Yuichiro EGUCHI, Susumu SAITO, Yusuke SAUCHI
  • Patent number: 10766829
    Abstract: [Problem] The present invention seeks to provide a composition for plants that is highly safe and that contributes to early harvesting, increasing yield, and increasing added value of crops. Specifically, the present invention provides a yeast extract that, by addition to a foliar surface spray or to soil or water, provides an effect of promoting growth, an effect of root lengthening, an effect of improved taste, and an effect of increased amino acid content of a plant. A substance obtained from yeast that is edible and considered to be safe is preferred as the yeast extract. [Means for Solving the Problem] A yeast extract having a peptide content of 5 wt % or more and an RNA content of 5 wt % or more is sprayed onto or provided as fertilizer to a plant. The yeast extract is preferably derived from Candida utilis, which is edible and considered to be safe.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: September 8, 2020
    Assignee: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Tomohiro Nakagawa, Yoshie Yasumatsu, Naoto Kaji, Kenichi Ason
  • Publication number: 20200255874
    Abstract: An object of the present invention is to provide a novel method for producing L-cysteine in place of a conventional fermentation method. More specifically, the object is to provide a method for producing L-cysteine by the combination of heat-resistant enzymes. In particular, the object is to provide a method for efficiently producing a pathway for synthesizing O-phosphoserine from 3-phosphoglyceric acid (3PG) via phosphohydroxypyruvic acid (HPV). The present invention solved the problem by a method for producing O-phosphoserine including acting phosphoserine aminotransferase (PSAT) and 3-phosphoglycerate dehydrogenase (PGDH) that are each derived from a thermophilic bacterium on 3PG to generate O-phosphoserine, and a method for producing L-cysteine including the step described above.
    Type: Application
    Filed: September 20, 2017
    Publication date: August 13, 2020
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., OSAKA UNIVERSITY
    Inventors: Kohsuke HONDA, Makoto IMURA, Ryo IWAKIRI
  • Publication number: 20200214334
    Abstract: A method for producing a foaming material for a composition to be foamed, the method includes: suspending a yeast cell residue in water; adjusting a pH of a yeast cell suspension to an acidic side; and heating a yeast cell suspension, the foaming material includes a yeast extract having a protein content of 35% by weight or more per solid content and a dietary fiber content of 30% by weight or more per solid content, and the foaming material is contained in the composition at from 0.001% to 1% by weight.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Applicant: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Eiji NAKAO, Kenichi ASON, Naoto KAJI
  • Publication number: 20190307823
    Abstract: [Problem] To provide an agent suppressing an increase in blood sugar level, said agent being capable of controlling blood sugar level even in a patient having normal blood sugar level or a patient corresponding to pre-diabetes, showing little side effects and being derived from a safe food. Also, the present invention addresses the problem of providing foods and drinks, i.e., foods including health foods, functional foods, health supplements, etc. as well as drinks, each comprising the aforesaid composition. [Solution] An extract of yeast to be used as an active ingredient. As the extract of yeast, it was found that a yeast extract, which can be obtained by a simple procedure comprising treating a yeast with hot water, an acid or an alkali, and/or an enzyme, has an improved effect of suppressing an increase in blood sugar level.
    Type: Application
    Filed: May 16, 2017
    Publication date: October 10, 2019
    Applicant: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Tomomi SAIKI, Kazuhiro HAMASAWA
  • Publication number: 20190191749
    Abstract: [Problem] Low-salt processed foods or drinks frequently taste like something is missing because of the less salty taste thereof. Although salt substitutes and flavoring agents are often used to offer a sense of satisfaction, these additives exhibit only limited effects or cause sonic troubles of, for example, changing the original flavor of food. Under these circumstances, the present invention addresses the problem of enhancing the salty taste of a low-salt processed food or drink without imparting any undesired taste thereto. [Solution] To solve the above problem, the present inventors conducted intensive studies and, as a result, found that an effect of comfortably and naturally enhancing salty taste can be achieved by adding a composition, which comprises dietary fibers, in particular, glucan and mannan at a specific ratio, to common processed foods or drinks including low-salt processed foods or drinks.
    Type: Application
    Filed: May 15, 2017
    Publication date: June 27, 2019
    Applicant: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Yuki SAITO, Yoshie YASUMATSU, Kenichi ASON
  • Patent number: 10285421
    Abstract: [Problem] To make a color of a processed food containing anthocyanin pigment into a vibrant color. In this respect, using a common foodstuff that is cheap and highly safe, without adding a coloring agent, and not imparting an incongruous flavor to the food is preferred. [Means for Solving the Problem] To an anthocyanin pigment or a common processed food containing anthocyanin pigment is added, in an appropriate amount, a yeast extract containing 5 wt % or more of a peptide, 5 wt % or more of RNA, 4 wt % or less of free amino acid, and preferably further containing 15 wt % or more of dietary fiber.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: May 14, 2019
    Assignee: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Yoshie Yasumatsu, Yuki Saito, Kenichi Ason
  • Publication number: 20190125822
    Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.
    Type: Application
    Filed: December 26, 2018
    Publication date: May 2, 2019
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITY
    Inventors: Takaomi KESSOKU, Atsushi NAKAJIMA, Yoshio SUMIDA, Yuichiro EGUCHI, Susumu SAITO, Yusuke SAUCHI
  • Patent number: 10196430
    Abstract: To provide effective use from a yeast extract residue, an excess of which is produced as a byproduct of yeast extract, or reduction in amount of the yeast extract residue. Also to obtain various useful substances. A cell wall lytic enzyme having no protease is allowed to act on a yeast extract residue, after which a heat treatment is performed at 70 to 80° C. for 10 to 20 minutes, thereby enabling separation into a fraction of primarily cell walls and a fraction of primarily protein. A yeast protein having a protein content of 60% or more is obtained from the fraction of primarily protein and, by subjecting the yeast protein to enzymatic degradation, a seasoning having a high amount of total nitrogen is obtained.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: February 5, 2019
    Assignee: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Kenichi Ason, Yusuke Fukuda, Setsuko Hirakura, Hiroko Kodera, Eiji Nakao
  • Publication number: 20180271138
    Abstract: [Problem] To manufacture a foaming member using a low-cost method having little environmental impact, in which the air bubbles in an air-bubble-containing product are enhanced and stability is improved, without imparting viscosity, coloring, flavor, cloudiness, odor, etc. Also, to provide an effective use of yeast cell residue generated as a byproduct of a yeast extract. [Solution] A yeast cell residue remaining after a useful extract is removed from a yeast is suspended in water, and is heated after pH adjustment, and then a supernatant is obtained by centrifugal separation. This fraction contains, in relation to the solid content, 35 wt % or more of protein and 30 wt % or more of dietary fiber, and is usable in the foaming member.
    Type: Application
    Filed: November 9, 2016
    Publication date: September 27, 2018
    Applicant: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Eiji NAKAO, Kenichi ASON, Naoto KAJI
  • Patent number: 10023836
    Abstract: In order to provide a culture medium eliminating variation by lot of component concentrations, the present invention provides a culture medium, and preferably a chemical-synthetic culture medium, imparting a proliferation ability to yeast that is equivalent to or greater than that of a YPD culture medium. A culture medium is provided which includes sugars as a carbon source capable of being assimilated by yeast; amino acids as a nitrogen source; vitamins; inositol; zinc ion (Zn2+); potassium ion (K+), and magnesium ion (Mg2+), and in which inositol concentration is between 50 and 10,000 mg/L.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: July 17, 2018
    Assignees: YAMAGUCHI UNIVERSITY, KOHJIN LIFE SCIENCES CO., LTD.
    Inventor: Rinji Akada
  • Publication number: 20180072634
    Abstract: [Problem] The present invention seeks to provide a composition for plants that is highly safe and that contributes to early harvesting, increasing yield, and increasing added value of crops. Specifically, the present invention provides a yeast extract that, by addition to a foliar surface spray or to soil or water, provides an effect of promoting growth, an effect of root lengthening, an effect of improved taste, and an effect of increased amino acid content of a plant. A substance obtained from yeast that is edible and considered to be safe is preferred as the yeast extract. [Means for Solving the Problem] A yeast extract having a peptide content of 5 wt % or more and an RNA content of 5 wt % or more is sprayed onto or provided as fertilizer to a plant. The yeast extract is preferably derived from Candida utilis, which is edible and considered to be safe.
    Type: Application
    Filed: March 16, 2016
    Publication date: March 15, 2018
    Applicant: KOHJIN LIFE SCIENCES CO., LTD.
    Inventors: Tomohiro NAKAGAWA, Yoshie YASUMATSU, Naoto KAJI, Kenichi ASON
  • Publication number: 20180050078
    Abstract: An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.
    Type: Application
    Filed: March 2, 2016
    Publication date: February 22, 2018
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, SAGA UNIVERSITY
    Inventors: Takaomi KESSOKU, Atsushi NAKAJIMA, Yoshio SUMIDA, Yuichiro EGUCHI, Susumu SAITO, Yusuke SAUCHI
  • Patent number: 9885005
    Abstract: [Problem] To provide a phospholipid ?-linolenic acid composition of consistent quality and having a stable supply of source material, with focus on Torula yeast, which is edible and recognized as safe, in order to resolve issues with omega 3 sources. [Means for Solving the Problem] As a result of intensive study to resolve the above-noted issues, the inventors of the present invention have discovered that a phospholipid ?-linolenic acid composition can be obtained using residue of yeast extract extracted from Torula yeast (Candida utilis), for example, which is currently produced in large quantities for application in foods, and so arrived at the present invention.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: February 6, 2018
    Assignees: KOHJIN LIFE SCIENCES CO., LTD., HIROSAKI UNIVERSITY
    Inventors: Naoto Kaji, Shiroh Aida, Katsuhiro Osaki, Masato Omae, Tomohiro Nakagawa, Motoyuki Tokuriki, Hayato Maeda
  • Publication number: 20170258097
    Abstract: [Problem] To produce a frozen bread dough improver that has an effect of improving rising of frozen bread dough, is highly safe, and tasteless, using a method that is low-cost and low in environmental impact. Also, to effectively use yeast cell body residue produced as a byproduct of yeast extract. [Means for Solving the Problem] Yeast cell body residue remaining after extracting useful extract from yeast is suspended in water and heated, after which the suspension is subjected to centrifugal separation and a supernatant is obtained. This fraction contains, per solid content, at least 45 wt % RNA, at least 5 wt % dietary fiber, and at least 10 wt % protein, and mannan content in the dietary fiber is at least 60 wt %. This can be used to improve rising of frozen bread dough.
    Type: Application
    Filed: August 28, 2015
    Publication date: September 14, 2017
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., THE SCHOOL CORPORATION KANSAI UNIVERSITY
    Inventors: Hidehisa KAWAHARA, Eiji NAKAO, Kenichi ASON, Sakiko IKEDA
  • Publication number: 20170224790
    Abstract: The present invention features compositions that include a fungal glucosylceramide (GlcCer) purified from a non-pathogenic fungus (e.g., Candida utilis) and, optionally, an adjuvant. The invention also features methods of treating a patient who has a fungal disease and methods of preventing a fungal disease in a subject by administration of these compositions. Also within the scope of the invention are methods of formulating a fungal vaccine by: (a) providing a fungal glucosylceramide isolated from a non-pathogenic fungus; and (b) combining the fungal glucosylceramide with an adjuvant in a physiologically acceptable excipient.
    Type: Application
    Filed: September 30, 2015
    Publication date: August 10, 2017
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Maurizio DEL POETA, Visesato MOR, Toshiya SATO, Tomohiro NAKAGAWA