Abstract: Embodiments of the invention provided methods and systems for collagen remodelling of an area of skin of a subject using a collagen remodelling device. The method may comprise heating, by a heater unit of the device, a liquid to a temperature configured to cause micro burns to the skin of the subject when the liquid is in contact with the skin of the subject and injecting the liquid, using a needleless injection unit of the device, from a liquid reservoir of the device into the area of skin of the subject.

Abstract: A device for repetitive needleless injection including a handheld unit having at least a cell fillable with a liquid, and a propulsion mechanism to apply a sequence of pressure pulses to the liquid to eject a micro-jet of the liquid from the cell via an orifice with a velocity that is sufficient to enable the micro-jet to penetrate into the surface; a reservoir that is connected to the cell by a conduit to enable the liquid to flow from the reservoir to the cell; a controller that is configured to operate the propulsion mechanism repeatedly; and a unidirectional valve to enable flow of the liquid from the reservoir to the cell and to prevent backflow. The propulsion mechanism includes an impulse generator configured to displace an actuation surface to generate the pulse; a plunger to transmit the pulse to the cell, and a restoration mechanism to retract the plunger.

Abstract: A device for repetitive needleless injection including a handheld unit having at least a cell fillable with a liquid, and a propulsion mechanism to apply a sequence of pressure pulses to the liquid to eject a micro-jet of the liquid from the cell via an orifice with a velocity that is sufficient to enable the micro-jet to penetrate into the surface; a reservoir that is connected to the cell by a conduit to enable the liquid to flow from the reservoir to the cell; a controller that is configured to operate the propulsion mechanism repeatedly; and a unidirectional valve to enable flow of the liquid from the reservoir to the cell and to prevent backflow. The propulsion mechanism includes an impulse generator configured to displace an actuation surface to generate the pulse; a plunger to transmit the pulse to the cell, and a restoration mechanism to retract the plunger.

Abstract: A device for repetitive needleless injection of a liquid into a surface includes a handheld unit that includes at least a cell that is fillable with the liquid. A propulsion mechanism is configured to apply a sequence of pressure pulses to the liquid. Each pulse ejects a micro jet of the liquid from the cell via an orifice between the cell and the exterior of the handheld unit with a velocity that is sufficient to enable the micro-jet to penetrate into the surface. A reservoir is connected to the cell by a conduit to enable the liquid to flow from the reservoir to the cell to replace the liquid that is ejected in the micro-jet. A controller is configured to operate the propulsion mechanism repeatedly so as to eject the sequence of the micro-jets.