Abstract: A pipette comprising a frame portion shaped as a handle, inside which a cylinder is formed as well as a piston fitted into the cylinder by means of a seal ring, a piston rod connected to the piston, and a press knob with shaft fitted to the upper end of the frame portion. The shaft of the press knob is fastened to the piston rod, which is by means of a seal ring guided into the cylinder space. A connecting channel passes through the piston and partly through the piston rod from the bottom end of the piston into the cylinder space. The bottom end of the piston or an extension part attached to same and provided with a through channel constitutes the tip of the pipette, to which the tip vessel is designed to be connected. When the press knob is depressed, the piston moves down and, at the same time, outwards from the cylinder space so as to suck liquid into the tip vessel by means of the vacuum in this way formed through the channel passing through the piston rod, piston, and possible extension part.