Abstract: An image data processor (106) includes a structural image data processor (114) that employs a multi-structure atlas to segment a region of interest from structural image data that includes tissue of interest and that segments the tissue of interests from the region of interest. The image data processor further includes functional image data processor (116) that identifies the tissue of interest in functional image data based on the segmented tissue of interest. An image data processor includes a multi-structure atlas generator (104) that generates a multi-structure atlas. The multi-structure atlas physically maps structure to tissue of interest such that locate the structure in structural image data based on the multi-structure atlas localizes the tissue of interest to the region of interest.