Patents Assigned to Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V.
  • Patent number: 4010264
    Abstract: Novel heterocyclic amides of the formula ##STR1## wherein R is selected from the group consisting of lower alkyl and aryl optionally substituted with at least one member of the group consisting of chlorine, fluorine, nitro, amino and lower alkyl and a tertiary alkyl group, R.sub.1 is selected from the group consisting of hydrogen, lower alkyl, carboxyl, lower alkoxycarbonyl, an alkali metal, alkaline earth metal or amine salt of carboxyl, a carbamyl, cyano, an amino and chlorine, R.sub.
    Type: Grant
    Filed: December 17, 1974
    Date of Patent: March 1, 1977
    Assignee: Koninklijke Nederlandsche Gist-en Spiritusfabriek N.V.
    Inventors: Peter Wolfgang Henniger, Peter Max Smid
  • Patent number: 4000129
    Abstract: Novel 6-substituted amino-penicillanic sulfoxide silyl esters useful as intermediates for the preparation of 7-aminodesacetoxycephalosporanic acids derivatives.
    Type: Grant
    Filed: August 26, 1974
    Date of Patent: December 28, 1976
    Assignee: Koninklijke Nederlandsche Gist-en Spiritusfabriek N.V.
    Inventor: Jan Verweij
  • Patent number: 3993783
    Abstract: High protein active dried bakers' yeast having excellent gas production is prepared from yeast strains Ng 2031 and Ng 2103 having a protein content of 47 to 60%. Drying is carried out by dividing fresh compressed yeast into particles followed by contacting the particles with a stream of hot air initially at a maximum temperature of 160.degree. C until the yeast is dried to at least 85% dry matter content by weight in not more than 120 minutes. The air temperature is gradually decreased so that the temperature of the yeast does not rise above 50.degree. C. A swelling and/or wetting agent may be mixed with the yeast before drying.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: November 23, 1976
    Assignee: Koninklijke Nederlandsche Gist-en Spiritusfabriek N.V.
    Inventors: Arend Langejan, Basile Khoudokormoff
  • Patent number: 3957972
    Abstract: The present invention relates to a clear, stable, aqueous solution of oxytetracycline for medical applications consisting essentially of from 1% to 5% by weight of oxytetracycline and water containing polyvinyl pyrrolidone and a magnesium compound, said aqueous solution having a pH in the range of from 8.0 to 9.5 and a concentration of polyvinyl pyrrolidone of from 2.5% to 7.49% as well as to the process of preparing the same. The oxytetracycline solutions are utilized in parenteral and peroral administrations, are free from adverse side effects and are stable over long periods of storage.
    Type: Grant
    Filed: June 28, 1972
    Date of Patent: May 18, 1976
    Assignee: Koninklijke Nederlandsche Gist-en Spiritusfabriek N.V.
    Inventors: Hubert Antonius Weber, deceased, Adrianus Pieter Molenaar
  • Patent number: 3943123
    Abstract: Novel .beta.-lactams containing a free carboxylic group of the formula: ##EQU1## wherein A and B are each selected from the group consisting of alkyl, including but not limited to branched alkyl, aryl, aralkyl and monocyclic heterocyclic groups at least one of A and B having a free carboxylic group. Further potential substituents of A and B are members of the group consisting of hydroxy, alkoxy, halogen, nitro, --NH.sub.2, monoalkylamino and dialkylamino groups, X is selected from the group consisting of hydrogen, alkyl, aryl and monocyclic heterocyclic, Y is selected from the group consisting of hydrogen, alkyl and aryl, and Z is selected from the group consisting of alkyl, alkoxy, aryloxy, aralkoxy, alkylthio, arylthio, aralkylthio, --CN, --COO-alkyl and --N.sub.3, useful as antibiotics and for the preparation of polymers and .beta.-amino acids, novel process for their preparation and novel imines used as starting materials for the said .beta.-lactams.
    Type: Grant
    Filed: February 14, 1974
    Date of Patent: March 9, 1976
    Assignee: Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V.
    Inventor: Ajay K. Bose