Abstract: A method (and system) is provided obtaining an adapted calibration transformation for whole slide imaging, wherein the adapted calibration transformation is for outputting the color of an empty area of the slide in a whole slide image, WSI, as a desired color. The method comprises first receiving a color target WSI in a device-dependent color space, wherein the color target WSI is a WSI of a color target from a scanner represented in the device-dependent color space. The color target contains at least a white patch and three (near) primary color patches. A calibration transformation is obtained for transforming the device-dependent color space to a device-independent color space. A chromatic adaptation transformation is derived using the color of the white patch in the device-dependent color space, the color of the empty (glass) area in the device-independent color space and the desired empty (glass) color in the target color space.

Abstract: This application relates to devices and methods of authenticating messages exchanged over a network between a transmitter and a receiver. The transmitter generates a truncated MAC code by selecting predetermined bits from a message authentication code (MAC) computed over a concatenation of a part of the message with a part of a previously transmitted message. The transmitter appends the truncated MAC code to the message for transmission. The receiver receives a previously transmitted message, the currently transmitted message, and the truncated MAC code, and generates an expected truncated MAC code by selecting predetermined bits from a message authentication code (MAC) computed over a concatenation of the part of the message with the previously transmitted message. The receiver authenticates the message and the previously transmitted message if the truncated MAC code as received is identical to the expected truncated MAC code.

Abstract: The present invention refers to providing a system that allows to very accurately determine the state of a disease, like COPD, in a patient. The system (100) comprises a unit (101) for providing images of the region of interest corresponding to different states of the region of interest, a unit (102) for elastically registering the images to each other resulting in an elastic registration output, a unit (103) for determining a specific tissue region in an image, a unit (104) for determining a specific elastic registration output for the specific tissue region based on the determined elastic registration output, and a unit (105) for determining an elastic indicator for the specific tissue type based on the specific elastic registration output. Thus, a state of a disease that influences the elastic properties of the specific tissue type can be determined very accurately.

Abstract: A wireless pressure sensing unit (20) comprises a membrane (25) forming an outer wall portion of a cavity and two permanent magnets (26,28) inside the cavity. One magnet is coupled to the membrane, and at least one magnet is free to oscillate with a rotational movement. At least one is free to oscillate with a rotational movement. The oscillation takes place at a resonance frequency, which is a function of the sensed pressure, which pressure influences the spacing between the two permanent magnets. This oscillation frequency can be sensed remotely by measuring a magnetic field altered by the oscillation. The wireless pressure sensing unit may be provided on a catheter (21) or guidewire.

Abstract: Methods and systems for predicting the susceptibility of bacterial pathogens to antibiotics using genomic data sets. Various embodiments described herein receive a genomic dataset and a set of labels and run principal variance component analysis thereon to determine the effect sizes of the labels. One or more labels are then selected based on their effect sizes and used in a machine learning model to make predictions on future datasets.

Abstract: The present invention relates to a system (1010) for X-ray dark field, phase contrast and attenuation image acquisition, the system comprising: an X-ray source (1020); an interferometer arrangement (1030); an X-ray detector (1040); a control unit (1050); at least one vibration transducer (1080); a processing unit (1090); and an output unit (1060). An axis is defined extending from a centre of the X-ray source to a centre of the X-ray detector. An examination region is located between the X-ray source and the X-ray detector, wherein the axis extends through the examination region, and wherein the examination region is configured to enable location of an object to be examined. The interferometer arrangement is located between the X-ray source and the X-ray detector, and wherein the interferometer arrangement comprises a first grating (1032) and a second grating (1034).

Abstract: Disclosed are imprinting ink compositions for use in imprinting techniques such as SCIL. The imprinting ink compositions comprise TMO nanoparticles stabilized by selected polymerization inhibitors that allow for the formation of a stable imprinting ink composition in which polymerization of the TMO nanoparticles is effectively suppressed and from which high refractive index patterned layers can be formed. Imprinting methods using such imprinting ink compositions, optical devices including patterned layers formed from such imprinting ink compositions and lighting devices, optical sensors and photovoltaic devices including such optical elements are also disclosed.

Abstract: The present invention relates to a system for indicating a position of an interventional device feature (11a) of an interventional device (11) respective an image plane (12) defined by an ultrasound imaging probe (18) of a beamforming ultrasound imaging system (15) in which the position of the interventional device feature (11a) is determined based on ultrasound signals transmitted between the ultrasound imaging probe (18) and an ultrasound transducer (16) attached to the interventional device at a predetermined distance (Lp) from the interventional device feature (11a). An icon providing unit (IPU) provides a first icon (Cde) indicative of a circular zone with a radius corresponding to the predetermined distance (Lp). The first icon (Cde) is displayed in a fused image that includes a reconstructed ultrasound image (RUI) from the beamforming ultrasound imaging system.

Abstract: Currently, there is interest in applying machine learning techniques to analyse digital pathology images automatically. Machine learning techniques often rely on training with a ground-truth image input. The quality and amount of training data determines the quality of the detector, as expressed in the rate of true and false positives, and robustness against variations in the appearance of the input images. The present application proposes to obtain image data of the same sample before and after at least one re-staining step (firstly with a structure-revealing stain, and secondly with a bio marker revealing stain). Sections of the first and second image data having a good registration relationship are chosen, along with the probability of detecting a desired candidate object (such as nucleus) and the probability of the bio marker revealing stain being present annotation data suitable for training a machine learning algorithm on the first and/or the second image data is provided.

Abstract: A multi-stage robot (10) comprises a sequential series arrangement of a flexible robot arm (30), a robot platform (40), a snake robot arm (50) and an end-effector (60). In operation, the multi-state robot (10) is introduced through an incision or an anatomical opening into an anatomical region enclosing an anatomical structure, and the snake robot arm (50) and the end-effector (60) are further introduced through an incision or an anatomical opening into the anatomical structure. The robot platform (40) is thereafter attached to the incision or the anatomical opening of the anatomical structure to facilitate an actuation of the snake robot arm (50) relative to the robot platform (40) to thereby target position the end-effector (60) within the anatomical structure. The multi-stage robot (10) may further comprise a robot base at the proximal end of the multi-stage robot (10) and attachable to the incision or the anatomical opening into the anatomical region.

Abstract: The invention relates to a method of identifying, from a number of ultrasound images (34) acquired during an ultrasound examination of a subject (6), the ultrasound image best suited to analyze a pre-determined anatomical structure of the subject. The method comprises the steps of (a) Providing a number of ultrasound images (34) acquired during an ultrasound examination of the subject; (b) Deriving at least one biometric parameter (96) related to the anatomical structure from a physical examination of the subject, (c) Retrieving a reference image (38) showing a target view of the anatomical structure (35); (d) For each of the number of ultrasound images (34), calculating an image similarity index between the ultrasound image and the reference image, (e) For at least the ultrasound image(s) having the best image similarity index, determining (100) a biometric parameter from the ultrasound image, and calculating a biometric similarity index, i.e.

Abstract: The invention provides a handheld imaging device capable of performing biplane imaging, wherein a first image plane or a second imaging plane (having different orientations) may be selected for image capture based on a motion characteristic of the device as determined by a sensor.

Abstract: An ultrasound imaging system transmits two beams in succession in the same beam direction, the waveform of the second beam being a phase inverted form of the first waveform, and each waveform containing first and second major frequency components. Echoes are received from along the beam direction in response to each beam transmission, and are processed by additively and subtractively combining the two echo sequences on a common depth basis. The echo components resulting from this processing extend from high frequencies for good near field resolution to low frequencies for good depth penetration, and include fundamental, harmonic, and sum or difference frequency components. The linear and nonlinear echo signal components may be frequency compounded for speckle reduction.

Abstract: A method and system for detecting sleep apnea involves determining the sleep stage, and detecting an apnea event based on a physiological sensor signal using selection of a detection algorithm which is dependent on the determined sleep stage. By taking account of the sleep stage when performing an automated apnea detection process, the accuracy of the apnea detection is improved.

Abstract: In a hair styling device (20) having a two-dimensional array (21) of elements to bring hair at a styling temperature, the elements produce optical radiation energy. The elements may include one or more LEDs, and preferably a plurality of LEDs, in which case the LEDS are driven in clusters that may be of mutually different shapes and sizes. The hair styling device (20) further comprises sensors to obtain an areal light absorption measurement opposed to the two-dimensional array of elements, and a control unit for individually controlling the elements in dependence of the measurement. The sensors may be arranged for measuring an areal light density profile of a whole treatment area. The hair styling device may radiate hair from two sides, both of which includes an areal light absorption measurement. The sensors may include LEDs that do not produce light.

Abstract: A connection mechanism (18) for connecting a workpiece (12) to a handle assembly (14) of an oral care device (10). A collet (30) has an axially extending beam (32) and a radially extending protrusion (34). The protrusion has a latching surface (44) that prevents disengagement of the workpiece from the handle assembly when in a locked configuration. A cam feature (40) is configured to convert an axial force exerted on the collet into radial deflection of the beam to transition the connection mechanism to an unlocked configuration in which the latching surface is disengaged from the corresponding surface of the workpiece. The beam is configured to return to the default position after the axial force is released due to strain energy in the beam resulting from the radial deflection.

Abstract: In an anti-biofouling context, an anti-biofouling system (20) is provided, which is configured to emit anti-biofouling light in an activated state thereof and to be applied to an object (10). Further, the anti-biofouling system (20) comprises a sensor system (30) that is configured to obtain measurement data relating to at least one structural feature of an anti-biofouling arrangement (1) including both the anti-biofouling system (20) and the object (10) in an actual case of the anti-biofouling system (20) being in place on the object (10). By having the sensor system (30) as mentioned in the anti-biofouling system (20), it is achieved that one or more structural aspects of the anti-biofouling arrangement (1) may be checked/monitored without a need for providing separate means for fulfilling such functionality.

Abstract: The invention provides a method for generating a non-invasive measure of blood vessel rigidity for a subject. The method includes obtaining 2D ultrasound data and 3D ultrasound data of the blood vessel from a given measurement location. The 2D ultrasound data provides information relating to a movement of the blood vessel and the 3D ultrasound data provides information relating to a shape of the blood vessel. A motion of the blood vessel is then determined based on the movement of the blood vessel. The method then includes providing the determined motion of the blood vessel, the shape of the blood vessel and an obtained non-invasive pressure measurement to a biomechanical model. A measure of rigidity is then determined based on the biomechanical model.

Abstract: Based in the field of breastfeeding, a breast pump apparatus (100) for expressing breast milk is disclosed. The breast pump apparatus (100) comprises a container unit (110) for receiving expressed breast milk, and a pump unit (120) including a pump body (130) and a pumping device (140) for applying negative pressure to a pump volume defined by the pump body (130). The pump body (130) comprises an inlet portion (132) adapted to be received on a female breast and an outlet portion (134) adapted to channel expressed milk to the container unit (110). The pump body (130) comprises an actuator element (200, 300, 400) comprising an active material capable of deforming upon application of a control signal to it, wherein deformation of the actuator element modifies at least one of a shape and size of the pump volume.