Abstract: The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.
Type:
Grant
Filed:
November 30, 2012
Date of Patent:
October 4, 2016
Assignee:
KORBA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Eun-Joo Roh, Kye-Jung Shin, Changjoon Justin Lee, Soo Jin Oh, Jung-Eun Park, Jeong Eun Yang, Eun Mi Hwang, Dong Ho Woo, Soon-Hyouk Lee, Dong-Gyu Kim, Hee-jung Chun, Wan-Keun Ji, Yun-Soo Na