Abstract: The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.
Type:
Grant
Filed:
November 25, 2009
Date of Patent:
October 30, 2012
Assignee:
Korea Institute of Bioscience and Biotechnology
Inventors:
Hyeong-Kyu Lee, Sei-Ryang Oh, Kyungseop Ahn, Joongku Lee, Sangku Lee, Ho-Jae Lee, Doo-Young Kim, Jung-Hee Kim, Eun-Ah Kim, Soon-Ja Choi, Soo Hyun Kim, Jung Weon Lee, Su-Yong Choi