Patents Assigned to Korea Institute of Oriental Medicine
  • Patent number: 11253566
    Abstract: A method for preventing or treating at least one of depression and anxiety disorder according to an embodiment of the present invention includes administering to a subject in need thereof a composition having an extract of Fraxinus rhynchophylla as an effective ingredient. By having an effect of improving depressive behavior and low physical activity shown in an animal model with induced anxiety and depression, reducing the level of cortisol, increasing the level of serotonin, and also increasing the expression amount of pCERB, BDNF, and mBDNF proteins in hippocampal tissues, the compositions can be advantageously used for developing a functional health food product or a pharmaceutical product for ameliorating or treating the depression and anxiety disorder.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: February 22, 2022
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Mi Young Lee, Yu Ri Kim, Bo-Kyung Park, Young Hwa Kim
  • Patent number: 11191801
    Abstract: The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, have an excellent effect in inhibiting the generation of the advanced glycation end-products in a human retinal pigment epithelial cell line subjected to a hyperglycemic or aging environment, and have excellent effects in delaying, preventing, and treating diabetic complications, muscular degeneration, commotio retinae, and lower extremity edema in various animal models of diabetic complications, macular degeneration, and lower extremity edema, and thus the mixture extract can effectively be used as an active ingredient for a composition for preventing and treating diabetic complications, including diabetic
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: December 7, 2021
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Jin Sook Kim, Junghyun Kim, Chan-Sik Kim, Eunjin Shon, Yun Mi Lee, Sojin Choi, Ik Soo Lee, Young Sook Kim, Dong Ho Jung, Bo-Jeong Pyun, Seung-Hyun Jung
  • Publication number: 20210315957
    Abstract: A pharmaceutical composition and a health functional food composition for preventing, treating, or improving muscular diseases have licorice extract or a fraction thereof, or a compound isolated therefrom or a pharmaceutically acceptable salt thereof, as an active ingredient. The licorice extract or a fraction thereof, the compound or salt thereof induce the myoblasts proliferation and promote the differentiation into myotubes, and since the licorice extract or a fraction thereof, the compound or salt thereof has an excellent effect on regenerating damaged muscles, various muscle diseases are effectively prevented, improved or treated using the composition.
    Type: Application
    Filed: June 17, 2020
    Publication date: October 14, 2021
    Applicants: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY, KOREA INSTITUTE OF ORIENTAL MEDICINE, DAEGU CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
    Inventors: Inho CHOI, Eun Ju LEE, So-young PARK, Yong-Ho LEE, Jin Yeul MA, Won-Kyung CHO, Hye Jin YANG
  • Patent number: 11146774
    Abstract: The present invention relates to a three-dimensional face image capturing method and comprises the steps of: capturing a face region of a user in a direction from a right chin to a left forehead; capturing the face region in a direction from a left forehead to a left chin; capturing the face region in a direction from a left chin to a right forehead; and capturing the face region in a direction from a right forehead to a center of face.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: October 12, 2021
    Assignee: Korea Institute of Oriental Medicine
    Inventors: Jun Hyeong Do, Young Min Kim, Jun Su Jang
  • Patent number: 11069152
    Abstract: Provided is a face pose correction apparatus for correcting a face pose, using a person-specific frontal model specialized for input three-dimensional (3D) facial data. The face pose correction apparatus may comprise: a generation unit for generating corrected first facial data by performing a 3D rigid transformation of input 3D facial data on the basis of a pre-stored 3D standard facial model; and a correction unit for generating a first subject-specialized frontal model which is a bilateral symmetry model of the first facial data, and correcting the first facial data by performing the 3D rigid transformation of the first facial data on the basis of the generated first subject-specialized frontal model.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: July 20, 2021
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Jun Su Jang, Jun Hyeong Do
  • Publication number: 20210105452
    Abstract: The present invention relates to a three-dimensional face image capturing method and comprises the steps of: capturing a face region of a user in a direction from a right chin to a left forehead; capturing the face region in a direction from a left forehead to a left chin; capturing the face region in a direction from a left chin to a right forehead; and capturing the face region in a direction from a right forehead to a center of face.
    Type: Application
    Filed: December 18, 2018
    Publication date: April 8, 2021
    Applicant: Korea Institute of Oriental Medicine
    Inventors: Jun Hyeong Do, Young Min Kim, Jun Su Jang
  • Publication number: 20200268827
    Abstract: A method for treating osteoarthritis according to an embodiment of the present invention includes administering to a subject in need thereof a composition comprising an extract of Alpinia oxyphylla. The extract of Alpinia oxyphylla can reduce the expression of IL-1?, IL-6, TNF-? and COX-2 as an inflammatory factor and also the expression of MMP-9 as a cartilage degeneration-inducing factor, and can heal the cartilage damage, and thus it can be advantageously used as a functional health food composition for prevention or improvement of osteoarthritis or a therapeutic agent for osteoarthritis.
    Type: Application
    Filed: September 12, 2018
    Publication date: August 27, 2020
    Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Dong Seon KIM, Yun Mi LEE, Eun Jung SON, Ji Youn KIM
  • Publication number: 20200245948
    Abstract: A method for determining a sharpness index of a pulse wave signal according to an embodiment comprises the steps of: receiving a pulse wave signal; determining a first reference line starting point and a second reference line starting point on the basis of a curvature of the pulse wave signal; determining a first reference line connecting the first reference line starting point and a first reference line ending point by determining the first reference line ending point by applying an intersecting tangent method to the first reference line starting point, and determining a second reference line connecting the second reference line starting point and a second reference line ending point by determining the second reference line ending point by applying the intersecting tangent method to the second reference line starting point; and determining a sharpness index by using a peak point of the pulse wave signal, the first reference line, and the second reference line.
    Type: Application
    Filed: September 18, 2018
    Publication date: August 6, 2020
    Applicant: Korea Institute of Oriental Medicine
    Inventors: Jang Han Bae, Young Ju Jeon, Jong Yeol Kim
  • Patent number: 10709754
    Abstract: The present invention relates to a composition for preventing, ameliorating, or treating hyperuricemia or metabolic disorders related with hyperuricemia comprising an extract of Alpinia oxyphylla as an effective ingredient. Because the extract of Alpinia oxyphylla of the present invention can reduce the uric acid amount in blood of an animal model and is derived from natural products, and the raw materials can be easily obtained, it can be widely used in industries that are related to hyperuricemia or metabolic disorders related with hyperuricemia. It can be effectively used for prevention, amelioration, or treatment of gout or gouty arthritis, in particular.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: July 14, 2020
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Dong Seon Kim, Ohn Soon Kim, Yun Mi Lee, Young-Sil Lee, Eun Jung Son
  • Patent number: 10617732
    Abstract: A health functional food composition and a pharmaceutical composition for preventing or ameliorating a non-alcoholic fatty liver disease include an extract of Dolichos lablab Linne as an active ingredient. The extract of Dolichos lablab Linne, being an active ingredient, effectively reduces accumulation of triglyceride in hepatocarcinoma cell line (HepG2). Therefore, the compositions are used for functional foods and medicines for the prevention or amelioration of non-alcoholic fatty liver.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: April 14, 2020
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Kwang-Hoon Song, Yun Hee Kim, Hye Won Lee, A-Rang Im
  • Patent number: 10537603
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which may cause macular degeneration, inhibits blood-retinal barrier breakdown causing retinal edema in various animal models, protects or treats a subretinal region causing dry macular degeneration, inhibits angiogenesis causing wet macular degeneration, and thus can be usefully used as an active ingredient for the composition for preventing and treating angioedema including macular degeneration, macular edema, retinal edema, or varicose veins.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: January 21, 2020
    Assignee: Korea Institute of Oriental Medicine
    Inventors: Jin Sook Kim, Junghyun Kim, Chan-Sik Kim, Eunjin Shon, Yun Mi Lee, Young Sook Kim, Sojin Choi, Ik Soo Lee, Dong Ho Jung, Bo-Jeong Pyun, Seung-Hyun Jung
  • Patent number: 10517913
    Abstract: A composition comprising a Lithospermi Radix extract as an effective component prevents, alleviates, or treats peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy). A method for preventing or treating peripheral neuropathy includes administering to a subject in need thereof the composition. The Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition, the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: December 31, 2019
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: No Soo Kim, Jong-Shik Park, Jin-Mu Yi, You Jin Lee, Eun-Sang Cho, Jinhee Kim, Chae Jun Lim, Ok-Sun Bang, Youngah Kim
  • Patent number: 10357528
    Abstract: The present invention relates to a pharmaceutical composition for preventing and treating corneal diseases or conjunctival diseases, containing a maple leaf extract as an active ingredient. The maple leaf extract exhibits an effect of inhibiting hyperemia in the eyeball in which hyperemia has been induced and an effect of inhibiting angiogenesis in the eyeball in which corneal damage has been induced, thus being effectively used in a pharmaceutical composition for preventing and treating corneal diseases or conjunctival diseases.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 23, 2019
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Jin Yeul Ma, Jung Hyun Kim, Jong Wook Jeon, You Chang Oh, Won Kyung Cho, Youn Hwan Hwang, Nam Hui Yim, Jae Myung Yoo
  • Patent number: 10328113
    Abstract: The present invention provides a method for preventing or treating an allergic disease, comprising administering to a subject a composition comprising an extract from Illicium verum as an active ingredient. The extract from Illicium verum of the present invention reduces the secretion amount of increased histamine by compound 48/80 and the production amount of the increased allergenic cytokines (TNF-?, IL-4 and IL-8) by PMA and A23187. The Illicium verum extract of the present invention reduces edema, dermatitis and IgE concentration of serum in atopic dermatitis mouse model. The Illicium verum extract of the present invention may be efficiently use for prevention, improvement or treatment of various allergic disease such as edema, hypersensitivity, contact dermatitis, atopic dermatitis, skin allergy, asthma or urticaria as pharmaceutical compositions, skin external applications, cosmetic compositions or food compositions.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: June 25, 2019
    Assignee: Korea Institute of Oriental Medicine
    Inventors: TaeSook Yoon, Yoon-Young Sung, Won-Kyung Yang, Ho Kyoung Kim
  • Patent number: 10168266
    Abstract: Present disclosure provides a portable viscometer including a body and a measuring unit disposed on one side of the body. The measuring unit includes a capillary tube detachably attached to the measuring unit, and a first sensor and a second sensor, the first and second sensors being disposed adjacent to the capillary tube and vertically spaced apart from each other, and the capillary tube includes a bead therein. The bead may be fixed on the inner surface of the capillary tube by a fixing compound which is soluble in a fluid to be measured.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: January 1, 2019
    Assignees: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Wan Joong Kim, Myeong Soo Lee, Moon Youn Jung, Dae-Sik Lee, Ju Ah Lee, Ho Young Lee
  • Patent number: 10098921
    Abstract: An anti-gout composition including the mixed extract of Chrysanthemum indicum and Cinnamomum cassia as an active ingredient shows substantially greater inhibitory effects on xanthine oxidase than when Chrysanthemum indicum or Cinnamomum cassia is used separately. An animal model treated with the mixed extract of Chrysanthemum indicum and Cinnamomum cassia experienced a decrease in uric acid in serum and in urine. The mixed extract of Chrysanthemum indicum and Cinnamomum cassia is an active ingredient induced from a natural material, and, accordingly, the mixed extract is safe and a source material therefor is easily provided. Accordingly, the mixed extract can be widely used in gout-related industries.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: October 16, 2018
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventor: Dong Seon Kim
  • Patent number: 9844575
    Abstract: The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract of Hedera helix leaves and Coptis chinensis as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract of Rheum palmatum, Puerariae radix, Ginkgo leaves, Cassiae semen, blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract of Hedera helix leaves and Coptis chinensis.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: December 19, 2017
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Jin Sook Kim, Jung Hyun Kim, Chan Sik Kim, Young Sook Kim, Eun Jin Shon, Yun Mi Lee, Dong Ho Jung, Ik Soo Lee, Gyu Hyeong Jo, Joo Hwan Kim
  • Patent number: 9839594
    Abstract: The present invention relates to a skin-moisturizing or wrinkle-improving external composition or cosmetic composition which contains, as an active ingredient, a compound represented by Formula 1, which can be extracted from Anemarrhena asphodeloides Bunge, or a pharmaceutically acceptable salt thereof. The composition prevents skin moisture loss and thus suppresses skin tissue damage induced by UV rays and so has a skin-wrinkle preventing or alleviating effect.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: December 12, 2017
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Sung Uk Chae, Mi Young Lee
  • Patent number: 9814749
    Abstract: The present invention relates to a composition for preventing or treating dementia containing an extract of Prunus mume (Fructus Mume), and the Prunus mume extract of the present invention has outstanding effects in improving spatial recognition ability and in normalizing hippocampal damage (normalizing ERK phosphorylation, increasing ChAT and normalizing NF-kappa B) induced by chronic vascular brain damage in a vascular dementia animal model, and hence can be used to advantage as a medicinal product for preventing or treating dementia diseases and as a functional health food for preventing or alleviating dementia diseases that accompany vascular brain damage such as vascular dementia.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: November 14, 2017
    Assignee: Korea Institute of Oriental Medicine
    Inventors: Won Kyung Jeon, Jung-Soo Han, Chang Hyun Han, Goya Choi
  • Patent number: 9782088
    Abstract: A pulse measuring device according to one embodiment of the present invention comprises: a measuring unit which is capable of spherical movement with multiple degrees of freedom; and a movement unit on which the measuring unit is mounted, and which has a spherical movement part for moving the measuring unit spherically with multiple degrees of freedom while also having a linear movement structure for moving the measuring unit linearly with multiple degrees of freedom. The measuring unit comprises: a unit body which is coupled so as to be able to rotate relative to an end part of the movement unit; a linking part which is coupled to a lower end part of the unit body and is able to rotate relative to the unit body; and a sensor part which is equipped with a pulse diagnosis sensor.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: October 10, 2017
    Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
    Inventors: Young Min Kim, Jae Uk Kim, Young Ju Jeon, Jong Yeol Kim, Si Woo Lee