Patents Assigned to Korea Institute of Science and Technology
  • Publication number: 20220370611
    Abstract: Disclosed are visible light-activatable antitumor self-assembled nanoparticles or antitumor immunity-inducing self-assembled nanoparticles. The self-assembled nanoparticles induce potent apoptosis in cancer cells and increase their own anticancer immunogenicity, thereby maximizing their therapeutic efficacy for cancer.
    Type: Application
    Filed: November 18, 2021
    Publication date: November 24, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kwangmeyung KIM, In-Cheol SUN, Man Kyu SHIM, Ji Woong CHOI
  • Publication number: 20220372231
    Abstract: The present disclosure relates to a UV- and heat-curable ladder-like polysilsesquioxane copolymer and a method for preparing the same. Since a controlled functionality can be provided only on a desired region via a thiol-ene click reaction without an additional additive, an insulating layer having a low dielectric constant and a microcircuit pattern can be formed without an additional etching process.
    Type: Application
    Filed: July 23, 2021
    Publication date: November 24, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Seung Sang HWANG, Soon Man Hong, Kyung Youl Baek, Chong Min Koo, Albert Lee, Seon Joon Kim, You Mee Choi
  • Patent number: 11506654
    Abstract: A method, a composition and a kit for screening an ALK or ROS-1 kinase inhibitor are disclosed in the present specification. In an aspect, by the method, composition and kit for screening an ALK or ROS-1 kinase inhibitor according to the present disclosure, it is possible to conduct simultaneous quantitative and qualitative analysis and faster screening of a larger number of candidate substances as compared with conventional molecular biological experimental methods and to grasp the overall level of change in a plurality of different metabolites in a cell line by candidate substances of ALK or ROS-1 kinase inhibitor and thus the screening efficiency for drugs which exert an ALK or ROS-1 kinase inhibitory effect is excellent. Consequently, the present disclosure has an advantage of being able to be used in various ways in the development of new drugs which exert an ALK or ROS-1 kinase inhibitory effect.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: November 22, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Byung Hwa Jung, Hyun Beom Lee, Naeun Yoon
  • Patent number: 11498976
    Abstract: The present invention relates to a viral complex comprising a viral vector capable of delivering shRNA that suppresses an expression of epidermal growth factor receptor (EGFR) to a cell and an anti-epithelial cell adhesion molecule (EpCAM) antibody conjugated to the viral vector, a pharmaceutical composition for preventing or treating cancer, comprising the viral complex, and a method for treating cancer, comprising administering the viral complex or the pharmaceutical composition to a subject in which a cancer disease has occurred and overexpressing EpCAM. The anti-EpCAM antibody-AAV2/shEGFR complex provided in the present invention significantly reduces the expression level of EGFR in tumor cells overexpressing EpCAM without inducing an immune response in vivo, thereby inducing death of tumor cells, and thus, it can be widely utilized in more effective and safe cancer treatment.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: November 15, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyung Jun Ahn, Sungjin Lee
  • Patent number: 11498946
    Abstract: The present disclosure relates to a pharmaceutical composition for combination therapy for preventing or treating cancer, which contains a first pharmaceutical ingredient containing a drug conjugate wherein an anticancer agent is bound at one end of an amphiphilic peptide represented by SEQ ID NO 1 and a poloxamer; and a second pharmaceutical ingredient containing an anti-PD-L1 antibody; as active ingredients. The pharmaceutical composition significantly inhibits cancer growth in in-vivo experiments and exhibits an effect of significantly enhancing immunotherapeutic effect by activating immune cells in cancerous tissues. In particular, the pharmaceutical composition for combination therapy according to the present disclosure has superior tumor accumulation efficiency and selectivity as compared to existing anticancer agents, and is very stable with little toxicity to normal tissues other than cancerous tissues.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: November 15, 2022
    Assignee: Korea Institute of Science and Technology
    Inventors: Kwangmeyung Kim, Ju Hee Ryu, Hong Yeol Yoon, Man Kyu Shim, Suah Yang
  • Patent number: 11492363
    Abstract: The present invention relates to a method for preparing size-modulated UiO-66, which is achieved by modulating the concentrations of reactants, and a catalyst with improved activity of hydrolyzing chemical warfare agents prepared by the method.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: November 8, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kyung Youl Baek, Chong Min Koo, Soon Man Hong, Seung Sang Hwang, Sangho Cho, Jin Young Seo, Do Xuan Huy, Younghan Song, Sejin Kim, Changju Sung, Yeojin Ahn
  • Patent number: 11491664
    Abstract: A robotic platform manipulating peripheral nerve system includes a manipulator and a recorder. The manipulator includes a rotating guide, a plurality of rotating movers and a plurality of manipulating units. The rotating guide has an opening portion through which the recorder records, and has a guide rail at a side. The rotating movers are combined with the rotating guide and move along the guide rail. The manipulating units are respectively fixed to the rotating movers, and a manipulating part performs the operation being connected to an end of each of the manipulating units.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: November 8, 2022
    Assignees: Korea Institute of Science and Technology, Research & Business Foundation Sungkyunkwan University
    Inventors: Keehoon Kim, Yong Seok Ihn, Donghyun Hwang, Sehyuk Yim, Sang Rok Oh, Jinwoo Jeong
  • Patent number: 11491352
    Abstract: A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: November 8, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ki Joo Pahk, Hyung Min Kim, Byung Chul Lee, Inchan Youn
  • Patent number: 11495708
    Abstract: Provided is a method of fabricating a see-through thin film solar cell, the method including preparing a substrate including a molybdenum (Mo) layer on one surface, forming see-through patterns by selectively removing at least parts of the Mo layer, sequentially depositing a chalcogenide absorber layer, a buffer layer, and a transparent electrode layer on the substrate and the Mo layer including the see-through patterns, and forming a see-through array according to a shape of the see-through patterns by removing the chalcogenide absorber layer, the buffer layer, and the transparent electrode layer deposited on the see-through patterns, by irradiating a laser beam from under the substrate toward the transparent electrode layer.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: November 8, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jeung Hyun Jeong, Hyeong Geun Yu, Jong Keuk Park, Won Mok Kim
  • Publication number: 20220346471
    Abstract: The present disclosure relates to an anti-droplet mask filter and an anti-droplet mask comprising the same, and more particularly, to a hydrophobic filter having ridges and an anti-droplet mask comprising the same. The present disclosure is directed to providing a mask filter with improved water repellency performance for effectively preventing the spread of acute respiratory syndrome virus infections. The super water-repellent anti-droplet nonwoven filter of the present disclosure shows superhydrophobicity with the surface contact angle of 160° or more due to the ridges that form a nanopatterned structure on the surface of hydrophobic fibers and the surface of bonding portions, thereby preventing the adsorption of droplets onto the surface of the filter. Additionally, the super water-repellent anti-droplet nonwoven filter of the present disclosure can capture ultrafine particles such as aerosols due to the nanopatterned structure on the surface of the super water-repellent anti-droplet nonwoven filter.
    Type: Application
    Filed: April 27, 2022
    Publication date: November 3, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Myoung-Woon Moon, Sang-jin Park, YOUNG A LEE, Hyseung Cho, Cho-hee Lee, Sunmi Yoon
  • Patent number: 11486777
    Abstract: Embodiments relate to a torsion sensor device which measures a degree of torsion of a measurement object by using a fiber Bragg gratings (FBG) sensor, the sensor device comprising: an FBG sensor including a sensing unit formed in one section of an elongated optical fiber; and a fixing device for fixing and supporting the FBG sensor to cause displacement of the FBG sensor according to motion of the measurement object, wherein the fixing device includes a bending prevention member to enable the sensing unit to have torsion displacement without bending displacement, according to the motion of the measurement object.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: November 1, 2022
    Assignee: Korea Institute of Science and Technology
    Inventors: Jinseok Kim, Sungwook Yang, Min Su Jang, Jun Sik Kim, Kyumin Kang, Bum-Jae You
  • Patent number: 11489014
    Abstract: A monolithic solar cell includes a first solar cell that is a sequential stack of an electrode, a silicon substrate, and an n-type emitter layer; a recombination layer disposed on the n-type emitter layer; an interfacial layer that is a double layer constituted of PEDOT:PSS and poly-TPD or PEDOT:PSS and PCDTBT, and that is disposed on the recombination layer; and a second solar cell that includes a p-type hole selective layer and a perovskite layer disposed on the p-type hole selective layer, the a p-type hole selective layer contacting and being integrated onto the interfacial layer of the first solar cell in a heat treatment during which the interfacial layer is partially decomposed, wherein the presence of the interfacial layer prevents a reduction in photoelectric conversion efficiency that occurs if the first solar cell and the second solar cell are combined without the presence of the interfacial layer.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: November 1, 2022
    Assignee: Korea Institute of Science and Technology
    Inventors: Doh Kwon Lee, Yoon Hee Jang, In Ho Kim, Hee Sun Yun, Jeung Hyun Jeong
  • Publication number: 20220339820
    Abstract: Disclosed is a recycling apparatus for a cross-linked polyethylene resin using a twin screw extruder. The recycling apparatus for a cross-linked polyethylene resin using a twin screw extruder according to an embodiment of the present disclosure includes: a raw material supply unit configured to supply a raw material that is a cross-linked polyethylene resin; and a twin screw extruder configured to receive the raw material from the raw material supply unit, the twin screw extruder including a cylinder and a twin screw installed inside the cylinder to rotate in the same direction, the twin screw extruder being configured to de-crosslink and recycle the raw material under a de-crosslinking reaction temperature and reaction pressure atmosphere while continuously transporting the raw material along the twin screw by the rotation of the twin screw.
    Type: Application
    Filed: October 14, 2021
    Publication date: October 27, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Soon Man HONG, Hang Kyu CHO, Seung Sang HWANG, Chong Min KOO, Seon Joon KIM, Albert LEE, Hwan Gyu LEE, Junpyo HONG
  • Publication number: 20220341605
    Abstract: Disclosed is a building system for reducing energy consumption. The building system includes an exterior wall layer disposed on an exterior wall of building walls, a circulation pipe disposed inside the exterior wall layer and through which a heating medium for absorbing heat caused by solar radiant energy applied to the exterior wall layer flows, and a thermal energy storage connected to the circulation pipe and configured to store the heat transmitted by the heating medium.
    Type: Application
    Filed: September 27, 2021
    Publication date: October 27, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sarng Woo KARNG, You Hwan SHIN, Myeong Seon CHAE, Hyun Ji KIM
  • Patent number: 11478852
    Abstract: Disclosed are: a metal nanostructure having a diameter of 2 nm to 2.5 nm; and a manufacturing method therefor. The formed metal nanostructure is provided as approximately spherical single-crystalline nanoparticles or amorphous alloy nanoparticles. Besides, a nanostructure fabricated in the form of an oxide has a nanoneedle shape. For formation of the metal nanostructure, an amorphous nanostructure is used. A second metal element having a higher standard reduction potential than a central metal constituting the amorphous nanostructure is used in the synthesis of the metal nanostructure.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: October 25, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Ka Hyun Hur, Min Seok Kim
  • Publication number: 20220330871
    Abstract: The present invention relates to an electrode, which is an in vivo insertable electrode, including a substrate, an electrically conductive layer formed on the substrate, a platinum black layer formed on the electrically conductive layer, a self-assembled monolayer (SAM) formed on the platinum black layer, and a lubricant layer formed on the SAM, a method of manufacturing the electrode, and a medical device including the electrode. The in vivo insertable electrode according to the present invention provides excellent electrical properties such as low impedance. Further, it shows that friction with tissue occurring when the electrode is inserted is reduced, and trauma during insertion and an immune rejection response after insertion is suppressed. Further, in the long term, it is possible to detect signals with high sensitivity throughout the entire period by preventing bioadhesion of in vivo cells, such as immune cells, and other proteins.
    Type: Application
    Filed: April 15, 2022
    Publication date: October 20, 2022
    Applicants: UIF (University Industry Foundation), Yonsei University, KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jungmok SEO, Yeontaek LEE, Il-Joo CHO, Hyogeun SHIN
  • Patent number: 11475340
    Abstract: A method, performed by an electronic device, of predicting an electronic structure of a material includes: receiving input data of a user related to elements constituting the first material; applying the received input data to a trained model for estimating a density of state of the first material; and outputting a first graph indicating the density of state for each energy level of the first material output from the trained model, wherein the trained model is trained to generate the first graph based on pre-input data about a plurality of second materials composed of at least some of the elements constituting the first material and a plurality of second graphs representing the density of state for each energy level of the plurality of second materials.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: October 18, 2022
    Assignee: Korea Institute of Science and Technology
    Inventors: Sang Soo Han, Byung Chul Yeo, Dong Hun Kim, Seung Chul Kim
  • Patent number: 11471224
    Abstract: Endoscope apparatus includes: a tube unit coupled to a rotary shaft to which a rotational force is transmitted so as to be rotatable, the tube unit being formed to extend in one direction; steering unit having one end installed at one end of the tube unit to rotate with respect to the tube unit so that a direction thereof facing forward is adjusted, the steering unit rotating together with the tube unit by the rotational force transmitted from the tube unit; an end effector installed inside the steering unit to rotate together with the steering unit due to the rotation of the steering unit, the end effector being disposed to face forward; and shaft-fixing tube body installed at the end effector, wherein the direction of the steering unit facing forward and relative rotation of the steering unit with respect to the end effector are adjustable.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: October 18, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Keri Kim, Geunwoong Ryu, Chulmin Park
  • Publication number: 20220323377
    Abstract: Provided is a pharmaceutical composition for preventing or treating osteoarthritis, the pharmaceutical composition including, as an active ingredient, obtusifolin, a derivative thereof, or a pharmaceutically acceptable salt thereof. The composition according to an aspect inhibits cartilage destruction-promoting factors and alleviates inflammatory responses, thereby exhibiting significantly excellent effects for preventing or treating osteoarthritis.
    Type: Application
    Filed: March 8, 2022
    Publication date: October 13, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Cheol-ho PAN, Kwang-hyun CHA, Song Yi KOO, Eun Ha LEE, Hee Ju LEE
  • Patent number: 11465114
    Abstract: The present specification discloses a membrane reactor comprising a reaction region; a permeate region; and a composite membrane disposed at a boundary of the reaction region and the permeate region, wherein the reaction region comprises a bed filled with a catalyst for dehydrogenation reaction, wherein the composite membrane comprises a support layer including a metal with a body-centered-cubic (BCC) crystal structure, and a catalyst layer including a palladium (Pd) or a palladium alloy formed onto the support layer, wherein ammonia (NH3) is supplied to the reaction region, the ammonia is converted into hydrogen (H2) by the dehydrogenation reaction in the presence of the catalyst for dehydrogenation reaction, and the hydrogen permeates the composite membrane and is emitted from the membrane reactor through the permeate region.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 11, 2022
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Young Suk Jo, Chang Won Yoon, Hyuntae Sohn, Hyangsoo Jeong, Seong Cheol Jang, Yeong Cheon Kim, Jonghee Han, Suk Woo Nam