Patents Assigned to Korea Research Institute of Bioscience and Biotechnology
  • Patent number: 10413579
    Abstract: The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: September 17, 2019
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, In Sik Shin, Hyung Won Ryu, Sang Woo Lee, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi, Doo Young Kim, Jung Hee Kim, Li Wan Yi, Jin Hang
  • Patent number: 10392596
    Abstract: Provided is a high throughput photobioreactor. The high throughput photobioreactor includes: a chamber; a plate installed in the chamber and mounted with a plurality of wells; a plurality of light sources installed in the chamber and irradiating light toward the plate; a light quantity controller positioned on an upper part of the plate to make quantities of light irradiated to the plurality of wells different; and a temperature controller controlling a temperature of the plate.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: August 27, 2019
    Assignees: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Shin Hwa Chung, Hee Sik Kim, Dae Hyun Cho, Hee Mock Oh, Jin A Heo
  • Patent number: 10376553
    Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-? and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: August 13, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei-Ryang Oh, Kyung Seop Ahn, Su Ui Lee, Hyung Won Ryu, Doo-Young Kim, Hyeong Kyu Lee, Ok-Kyoung Kwon, Jung Hee Kim, Hyun-Jun Lee, In-Sik Shin
  • Publication number: 20190204324
    Abstract: Provided are an autoantibody specifically binding to an exosomal protein EIF3A (Eukaryotic translation initiation factor 3 subunit A) or a fragment including an antigen-binding site (paratope) thereof, a hybridoma cell line producing the autoantibody, a polypeptide having an amino acid sequence of an antigenic determinant (epitope) specifically binding to the autoantibody, a composition for diagnosing liver cancer including an agent measuring an expression level of the autoantibody or the fragment including the antigen-binding site thereof, a kit for diagnosing liver cancer including the composition, and a method of providing information for diagnosis of liver cancer by using the composition. Further, provided is a method of screening for a therapeutic agent for liver cancer by using an expression level of the autoantibody.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 4, 2019
    Applicants: Korea Research Institute of Bioscience and Biotechnology, ProteomeTech Inc.
    Inventors: Eun Wie Cho, Chang Kyu Heo, Hai Min Hwang, Jeong Heon Ko, Kook Jin Lim, Hye Jung Lee
  • Patent number: 10336693
    Abstract: An oseltamivir analog and nanoparticles having the analog bound thereto, of the present invention, strongly bind to oseltamivir-resistant influenza virus, and thus, the use of the same can allow detection of oseltamivir-resistant influenza viruses quickly and conveniently with the naked eye. Therefore, the present invention can be favorably utilized in promptly establishing a therapeutic schedule for a patient infected with influenza viruses.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: July 2, 2019
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Juyeon Jung, Eun Kyung Lim
  • Patent number: 10301598
    Abstract: Provided herein are novel indoleacrylic acid-based compounds, and pharmaceutically acceptable salts thereof, useful for the production, maintenance and proliferation of pluripotent stem cells. Also provided are cell culture compositions comprising these compounds, and methods of using these compounds in the production and maintenance of pluripotent stem cells.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: May 28, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yee Sook Cho, Kyeong Lee, Jung Woon Lee
  • Patent number: 10281460
    Abstract: The present invention relates to a method for producing a Polyporus squamosus-derived PSL1b recombinant lectin, which binds specifically to sialic acid containing glycoconjugates, from an Escherichia coli PSL1b strain (deposit number: KCTC12507BP) or a Pichia pastoris PSL1b strain (deposit number: KCTC12500BP) and a lectin produced thereby. The recombinant lectin of the present invention can be useful as an active ingredient of a composition or a kit for measuring or detecting glycoproteins, glycopeptides, glycolipids, sugar precursors, or oligosaccharides having sialic acid moieties.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: May 7, 2019
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventor: Seonghun Kim
  • Patent number: 10267737
    Abstract: A near-infrared fluorescent probe for detecting ALP is represented by Chemical 1. The fluorescent probe capable of detecting ALP can selectively detect ALP only quickly and accurately. In addition, the fluorescent probe allows monitoring of a biological phenomenon occurring in cells and tissues through noninvasive in-vivo imaging and during the early osteogenic differentiation in real time.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: April 23, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Chang-Soo Lee, Chul Soon Park, Oh Seok Kwon, Tai Hwan Ha
  • Patent number: 10231999
    Abstract: The present invention relates to a method for producing cholinergic neurons comprising obtaining neural progenitor cells from stem cells so as to continuously produce cholinergic neural cells with high purity and the same traits, followed by differentiating the neural progenitor cells into the cholinergic neurons, and cholinergic neurons produced therefrom. Since the method of preparing the cholinergic neurons provided in the present invention enables not only production of the cholinergic neurons with high purity, but also rapid production of the cholinergic neurons with the same traits, it can be widely used for effectively treating degenerative cranial nerve diseases such as Alzheimer's disease.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: March 19, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sang Chul Lee, Baek Soo Han, Kwang-Hee Bae, Hyejin Kim, Won Kon Kim, Kyoung Jin Oh
  • Patent number: 10226486
    Abstract: The present invention relates to a method for preparing induced dopaminergic neuronal progenitors (iDPs) comprising inducing an expression of Oct4, Sox2, Klf4, and c-Myc genes in adult cells and direct reprogramming of the adult cells to the iDPs by treating the cells with sonic hedgehog (SHH) and fibroblast growth factor 8 (FGF8); and a cell therapy product and a composition for treating or preventing Parkinson's Disease (PD) which comprises the iDPs as active ingredients. In addition to this, the present invention relates to a method for preparing midbrain dopaminergic neurons comprising isolating NSC-like colony by culturing the iDPs, dissociating the isolated NSC-like colony, and culturing the cells on the neural cell differentiation medium. Further, the present invention relates to a method for treating PD or a method for screening medicine for preventing or treating PD using the cells of the present invention.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: March 12, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yee Sook Cho, Jang Hwan Kim, Han Seop Kim
  • Patent number: 10195266
    Abstract: The present invention relates to a versatile influenza virus vaccine composition using the HA2 helical domain of a hemagglutinin protein, which is an influenza surface protein, and to a pharmaceutical composition for preventing or treating influenza virus infectious diseases. The polypeptide expressed by SEQ ID NO: 3 and the polypeptide expressed by residues 379 to 474 of SEQ ID NO: 1 of the present invention can be mass-produced in E. coli, and effectively produce neutralizing antibodies to various influenza virus subtypes, and thus the polypeptides can be widely utilized as versatile vaccines for influenza virus subtypes and new influenza virus variants.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 5, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Dae Gwin Jeong, Dae Sub Song, Sun Woo Yoon
  • Patent number: 10188594
    Abstract: The present invention relates to a fermented vegetable oil, to a method for preparing the oil, and to a composition including the oil. More particularly, the present invention relates to a technique for providing a fermented vegetable oil having the effects of enhancing emulsion stability due to water retention ability, improving texture and flavor, and enhancing moisturization.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: January 29, 2019
    Assignees: DAMY CHEMICAL CO., LTD., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Kwang-Nyeon Kim, Ju-Hyun Son, Hee-Sik Kim, Jong-Seok Yun
  • Patent number: 10174312
    Abstract: The present invention relates to a screening method for a drug target gene by using chemical-genetic profile compendium of the heterozygous deletion fission yeast strain and the comparative genetic analysis using the same. More precisely, the present inventors constructed the chemical-genetic profile compendium for drug candidates from the heterozygous deletion fission yeast strain of Schizosaccharomyces pombe (S. pombe), and then compared with the compendium with the chemical-genetic profile compendium of the budding yeast Saccharomyces cerevisiae (S. cerevisiae) in order to select efficiently drug target genes showing drug sensitivity. The screening method of the present invention can be efficiently used for the identification of a drug target gene in various eukaryotes because it facilitates the selection of a drug target gene showing sensitivity to the drug from the chemical-genetic profile compendium of the heterozygous deletion fission yeast strain.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: January 8, 2019
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Dong-Uk Kim, Kwang-Lae Hoe
  • Patent number: 10172816
    Abstract: A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 8, 2019
    Assignees: YUNGJIN PHARMACEUTICAL CO., LTD, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yongnam Lee, Ji-seok Yoo, Dae-hee Shin, Byung-hwan Ryoo, Kyung Seop Ahn, Sei Ryang Oh, Hyeong Kyu Lee, In Sik Shin, Doo Young Kim, Ok-Kyoung Kwon, Hyuk Hwan Song, Seung Hyung Kim, SuUi Lee
  • Publication number: 20180360897
    Abstract: The present invention relates to: a composition comprising a Sicyos angulatus extract or a fraction thereof as an effective ingredient for preventing, alleviating, or treating liver diseases; and a method for preventing or treating liver diseases, comprising a step of administering the composition to a subject suspected of having a liver disease.
    Type: Application
    Filed: December 9, 2016
    Publication date: December 20, 2018
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Chul Ho LEE, Yong-Hoon KIM, Jung Ran NOH, Dong Hui CHOI, Jung Hwan HWANG, Kyoung Shim KIM, Yun-Jung SEO, In-Bok LEE, Jung-Hyeon CHOI
  • Publication number: 20180353561
    Abstract: A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-? and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
    Type: Application
    Filed: May 13, 2016
    Publication date: December 13, 2018
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei-Ryang OH, Kyung Seop AHN, Su Ui LEE, Hyung Won RYU, Doo-Young KIM, Hyeong Kyu LEE, Ok-Kyoung KWON, Jung Hee KIM, Hyun-Jun LEE, In-Sik SHIN
  • Patent number: 10150799
    Abstract: The present invention concerns lectins isolated from the fruiting body of a novel Hericium erinaceum (deposit number: KCTC 12499BP) NEU-1L strain which bind specifically to sialic acid. The invention further pertains to uses of such lectinsn abd to processes for their preparation thereby. The lectin of the present invention can be useful as an active ingredient of a composition or a kit for measuring or detecting glycoproteins, glycopeptides, glycolipids, sugar precursors or oligosaccharides containing sialic acid moieties, or further for measuring or detecting cell lines, bacteria and viruses containing sialoglycoconjugates.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: December 11, 2018
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventor: Seounghun Kim
  • Publication number: 20180340195
    Abstract: The present invention relates to a method for producing medium chain diol and, more particularly to recombinant microorganisms in which fatty alcohol dehydrogenase and/or fatty alcohol oxidase genes on a ?-oxidative metabolism pathway are deleted, the fatty aldehyde dehydrogenase genes are optionally deleted, and ?-oxidative metabolism pathway-related genes are deleted, and to a method for producing medium chain diol from fatty acid-derived alcohol or alkane by culturing the recombinant microorganisms. The recombinant microorganisms of the present invention can produce a high yield of medium chain diol by preventing further oxidation and ?-oxidative metabolism of fatty alcohols.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 29, 2018
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Jung Oh AHN, Hong Weon LEE, Min Jeong JANG, Chun Sug KIM, Gyu Yeon PARK
  • Patent number: 10136663
    Abstract: The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: November 27, 2018
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Woo-Song Lee, Young-Bae Ryu, Young-Min Kim, Su-Jin Park, Mun-Chual Rho, Hyung-Jae Jeong, Hyung-Jun Kwon
  • Publication number: 20180327724
    Abstract: The present invention relates to a method for producing a medium chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in ?-oxidative metabolic pathway and a ?-oxidative metabolic pathway-related gene are deleted and a ?-transaminase gene is introduced, and a method for producing a medium chain aminocarboxylic acid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and ?-oxidative metabolism and also produce a medium chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.
    Type: Application
    Filed: October 27, 2016
    Publication date: November 15, 2018
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Jung Oh AHN, Hong Weon LEE, Gyu Yeon PARK, Min Jeong JANG, Woo Young JEON