Patents Assigned to Korea Research Institute of Bioscience and Biotechnology
  • Patent number: 10920248
    Abstract: The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 16, 2021
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Cha Young Kim, Yu Jeong Jeong, Suk Weon Kim, Mun Chual Rho, Young Bae Ryu, Woo Song Lee, Jae Cheol Jeong
  • Patent number: 10908163
    Abstract: The present invention relates to a method for analyzing the interaction between a binding protein and a target material, including measuring the interaction between the binding protein and a target material using an interaction trapper (IT) cell. The IT cell has the binding protein displayed on the surface of intracellular inclusion bodies, i.e., insoluble aggregates, by expressing a fusion protein which forms active protein particles containing the binding protein. The method includes increasing cell permeability without affecting the activity of the binding protein displayed on the cells and genetic information.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: February 2, 2021
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Seung-Goo Lee, Yu Jung Kim, Jongsik Gam, Haseong Kim, Dae-Hee Lee, Heung-Chae Jung
  • Publication number: 20200407685
    Abstract: The present invention relates to a method for producing natural killer cells using direct reprogramming, natural killer cells produced thereby, a biomarker specific to the natural killer cells, a cell therapeutic agent comprising the natural killer cells, a composition for treatment and prevention of cancer, a cryopreservation cell vial for storing the natural killer cells, and a medium kit for inducing the direct reprogramming. Exhibiting excellent proliferative potential and cancer cell killing potential, the natural killer cells produced by the production method can be effectively utilized for mass production and in a composition for treatment and prevention of cancer.
    Type: Application
    Filed: September 21, 2018
    Publication date: December 31, 2020
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yee Sook CHO, Han-Seop KIM, Binna SEOL, In Pyo CHOI
  • Patent number: 10809263
    Abstract: Provided are an autoantibody specifically binding to an exosomal protein EIF3A (Eukaryotic translation initiation factor 3 subunit A) or a fragment including an antigen-binding site (paratope) thereof, a hybridoma cell line producing the autoantibody, a polypeptide having an amino acid sequence of an antigenic determinant (epitope) specifically binding to the autoantibody, a composition for diagnosing liver cancer including an agent measuring an expression level of the autoantibody or the fragment including the antigen-binding site thereof, a kit for diagnosing liver cancer including the composition, and a method of providing information for diagnosis of liver cancer by using the composition. Further, provided is a method of screening for a therapeutic agent for liver cancer by using an expression level of the autoantibody.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: October 20, 2020
    Assignees: PROTEOMETECH INC., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Eun Wie Cho, Chang Kyu Heo, Hai Min Hwang, Jeong Heon Ko, Kook Jin Lim, Hye Jung Lee
  • Patent number: 10792323
    Abstract: The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: October 6, 2020
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Won Gon Kim, Baek Soo Han, Jeong Su Byun, Ha Young Choi
  • Patent number: 10774381
    Abstract: The present invention relates to a genetic marker for determining meat quality traits of pigs and a use thereof, and specifically, a genetic marker for determining meat quality traits of pigs, comprising a polynucleotide consisting of 5 to 300 consecutive nucleotides comprising the nucleotides from the 1524th to the 1527th positions in the polynucleotide of SEQ ID NO: 1, or a polynucleotide complementary thereto, a composition for determining meat quality traits of pigs comprising an agent capable of detecting the genetic marker, a composition for determining Korean native pigs, a kit, a microarray, a method for determining meat quality traits of pigs, and a method for determining meat quality traits of Korean native pigs.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: September 15, 2020
    Assignees: REPUBLIC OF KOREA (MANAGEMENT: RURAL DEVELOPMENT ADMINISTRATION), KOREA RESEARCH INSTITUTE OF BIOSCIENCES AND BIOTECHNOLOGY, JEJU NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: In Cheol Cho, Hee Bok Park, Jeong Woong Lee, Jin Seop Ahn, Sang Hyun Han
  • Patent number: 10765642
    Abstract: The present invention relates to sobrerol or a pharmaceutically acceptable salt thereof, which can promote differentiation of myoblasts to form myotubes, thereby preventing muscle weakness and effectively improving muscle functions. Therefore, the pharmaceutical composition containing the same can be effectively used for preventing or treating muscle weakness related diseases.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 8, 2020
    Assignees: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Ki Sun Kwon, Jeongi Choi, Sung Sup Park, Sun Gun Chung, Eun Soo Kwon, Kwang-Pyo Lee, Seung Min Lee
  • Patent number: 10765128
    Abstract: A composition for prevention or treatment of metabolic syndrome or for antioxidation includes black soybean leaf extracts and flavonol glycoside compounds isolated thereof as active ingredients.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: September 8, 2020
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Tae Sook Jeong, Ho Yong Park, Dong-Ha Shin, Myung-Sook Choi, Hua Li, Han-Young Cho, Hyeon-Seon Ji
  • Patent number: 10765669
    Abstract: The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 8, 2020
    Assignees: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Sungchan Cho, Miri Choi, Joo Youn Lee
  • Patent number: 10765655
    Abstract: The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-?, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: September 8, 2020
    Assignees: Enzychem Lifesciences Corporation, Korea Research Institute of BioScience and Biotechnology
    Inventors: Sei-Ryang Oh, Kyung Seop Ahn, Su Ui Lee, In Sik Shin, Ok-Kyoung Kwon, Seung Hyung Kim, Chan Mi Chun, Tae-Suk Lee, Yong-Hae Han, Ki Young Sohn, JongKoo Kang, Hye Kyung Kim
  • Patent number: 10760051
    Abstract: The present invention relates to a method for producing astrocytes comprising obtaining neural progenitor cells from stem cells so as to continuously produce astrocytes with high purity and same traits, followed by two steps of differentiating the neural progenitor cells into the astrocytes, and astrocytes produced therefrom. Since the method of preparing the astrocytes provided in the present invention enables not only production of the astrocytes with high purity and faster production of the astrocytes with same characteristics, but also rapid differentiation of the astrocytes using the neural progenitor cells when necessary, it can be widely used for effectively treating a patient with a disease which requires transplantation of the astrocytes.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: September 1, 2020
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Baek Soo Han, Sang Chul Lee, Kwang-Hee Bae, Cheonok Lee, Won Kon Kim, Kyoung Jin Oh
  • Patent number: 10751378
    Abstract: The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-?, or MIP-2.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: August 25, 2020
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang Oh, Kyung Seop Ahn, Seung Hyung Kim, In Sik Shin, Hang Jin, Jung Hee Kim, Hyung Won Ryu, Wan Yi Li, Sang Woo Lee, Joong Ku Lee, Sang Ho Choi
  • Patent number: 10713478
    Abstract: The present invention includes: a three-dimensional moving image generation module for generating a moving image of an experiment target person; an object extraction module for extracting the experiment target person, separately from a background, from the moving image; an object definition module for defining an object by measuring a length, a size and a weight center of the object and extracting a depth image of the object; a behaviour pattern definition module for defining a basic behaviour pattern of the object by cumulatively analyzing a movement speed and movement time of the weight center of the corresponding object, and changes in the extracted depth data when the object defined by the object definition module is extracted by the object extraction module; and a behaviour pattern analysis module for analyzing and identifying a lasting time and a frequency of the basic behaviour pattern with respect to the object.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: July 14, 2020
    Assignees: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sang Kuy Han, Keyoung Jin Chun, Kyu Tae Chang, Young Jeon Lee, Yeung Bae Jin, Kang jin Jeong, Phil Yong Kang, Jung Joo Hong, Sang Rae Lee
  • Patent number: 10695390
    Abstract: The present invention relates to: a composition comprising a Sicyos angulatus extract or a fraction thereof as an effective ingredient for preventing, alleviating, or treating liver diseases; and a method for preventing or treating liver diseases, comprising a step of administering the composition to a subject suspected of having a liver disease.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: June 30, 2020
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Chul Ho Lee, Yong-Hoon Kim, Jung Ran Noh, Dong Hui Choi, Jung Hwan Hwang, Kyoung Shim Kim, Yun-Jung Seo, In-Bok Lee, Jung-Hyeon Choi
  • Publication number: 20200141948
    Abstract: The present invention relates to a composition and a kit for diagnosis of muscle weakness-related disease, which comprises agents for measuring the expression levels of gelsolin and tetranectin, and to a method of diagnosing muscle weakness-related disease by using the same. The composition, kit and method for diagnosis of muscle weakness-related disease according to the present invention make it possible to diagnose muscle weakness-related disease in an easy and rapid manner by molecular diagnosis, thereby systemically managing the muscle weakness-related disease while increasing therapeutic efficacy against the muscle weakness-related disease.
    Type: Application
    Filed: June 19, 2018
    Publication date: May 7, 2020
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Ki-Sun KWON, Ju Yeon KWAK, Seung-Min LEE, Jeong Yi CHOI, Kwang-Pyo LEE, Eun-Soo KWON
  • Publication number: 20200115683
    Abstract: Provided are a method of preparing in vitro-matured intestinal organoids, and intestinal organoids prepared by the method.
    Type: Application
    Filed: October 10, 2019
    Publication date: April 16, 2020
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Mi Young Son, Janghwan Kim, Soo Jin Oh, Cho Rok Jung, Hyun Soo Cho, Hana Lee, Kwang Bo Jung
  • Publication number: 20200085803
    Abstract: The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.
    Type: Application
    Filed: December 15, 2017
    Publication date: March 19, 2020
    Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Sungchan CHO, Miri CHOI, Joo Youn LEE
  • Publication number: 20200046728
    Abstract: The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.
    Type: Application
    Filed: September 29, 2017
    Publication date: February 13, 2020
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Mun Chual RHO, Seung Woong LEE, Soyoung LEE, Sang-Hyun KIM, Kwon Moo PARK, Woo Song LEE, Kyungsook JUNG, Chan Sun PARK
  • Publication number: 20200029574
    Abstract: The present invention provides a strain of Pseudozyma churashimaensis RGJ1, which is isolated from a pepper plant and leads to induced systemic resistance against plant pathogens or plant viruses; a microbial preparation for controlling plant diseases or increasing plant yields, including, as an active ingredient, the strain or a culture thereof; a method for preparing the microbial preparation, including a step of culturing the strain; and a method for controlling plant diseases, including a step of performing dipping treatment, soil drenching treatment or spraying treatment onto aerial foliage for a plant seedling with the strain or the culture thereof.
    Type: Application
    Filed: June 27, 2016
    Publication date: January 30, 2020
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Choong-Min RYU, Ga-Hyung LEE
  • Publication number: 20200016225
    Abstract: The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.
    Type: Application
    Filed: November 13, 2017
    Publication date: January 16, 2020
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Won Gon KIM, Baek Soo HAN, Jeong Su BYUN, Ha Young CHOI