Patents Assigned to Korea Research Institute of Bioscience & Biotechnology
  • Gene from tidal flat metagenome and a novel protein displaying both phospholipase and lipase activities
    Patent number: 9441018
    Abstract: The present invention relates to a novel gene derived from a tidal flat metagenome, and a novel protein obtained therefrom showing the coactivity of phospholipase and lipase. Specifically, the novel gene isolated from the metagenome library of tidal flat sediments and the protein having phospholipase and lipase activities encoded from the novel gene: are expressed in a water-soluble form to be mass-producible; enable ultra high-purity protein to be obtained through single step purification using an Ni-NTA column; show good activity in the pH range of 5˜10; maintain good low temperature activity and stability up to a temperature of 3° C. to 40° C.; and have high resistance against various organic solvents. Therefore, the novel gene and the protein can be usefully used for various industrial fields such as the purification and conversion of oil and fat, bio-medicine, and fine chemistry.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: September 13, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Jung-Hoon Yoon, Mi Hwa Lee, Chul Hyung Kang, Ki Hoon Oh, Tae Kwang Oh
  • Variant microorganism able to produce large amount of fermentation product, and fermentation product production method using same
    Patent number: 9441251
    Abstract: The present invention relates to mutant microorganisms having a high ability to produce fermentation products, and methods for producing fermentation products using the same, and more particularly, to mutant microorganisms having a high ability to produce fermentation products such as lactic acid, succinic acid and ethanol, which has a deletion of genes selected from the genome of enteric bacteria and involved in respiration, electron transport, redox reactions and the like, and methods of producing fermentation products in high yield by culturing the mutant microorganisms under anaerobic conditions.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: September 13, 2016
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sang Jun Lee, Hyun Ju Kim, Dong-Woo Lee, Joong Su Kim, Haeyoung Jeong, Bo Kyeng Hou
  • Biological Synthesis of 6-Aminocaproic Acid and Transgenic Microorganism Therefor
    Publication number: 20160257976
    Abstract: The present invention relates to a method for preparing a recombinant microorganism simultaneously comprising genes encoding enzymes used in the biosynthesis pathway of 6-aminocaproic acid, which is a precursor of caprolactam, biosynthesizing 6-aminocaproic acid from the microorganism, and producing the same so as to synthesize caprolactam.
    Type: Application
    Filed: May 2, 2014
    Publication date: September 8, 2016
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hong-Weon Lee, Jung Oh Ahn, Joon Ki Jung, Hee-Ju Ko, Sun-Joo Park, Chun Sug Kim, Hyeok Won Lee, Eun Gyo Lee, Joo Hwan Lee
  • Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-]furan-2-carbohydrazide derivatives as an active ingredient
    Patent number: 9433607
    Abstract: The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: September 6, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bo Yeon Kim, Krisada Sakchaisri, Sun Ok Kim, Ramegowda Thimmegowda Naraganahalli, Nak Kyun Soung, Jong Seog Ahn, Joonsung Hwang, In Ja Ryoo, Jae-Hyuk Jang
  • Daphne genkwa extracts, and pharmaceutical composition containing fractions of the extracts or compounds separated from the extracts as active ingredients for preventing or treating atopic dermatitis
    Patent number: 9428520
    Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of atopy comprising the extract of Daphne genkwa, the fraction thereof, of the compound isolated from the same as an active ingredient. More precisely, the extract of Daphne genkwa, the fraction thereof, or the compound isolated from the same, genekwadapnin or yuanhuacine, of the present invention can increase the secretion of cytokine in Th1 immune cells and suppress atopy in the atopy mouse model, so that the extract of Daphne genkwa, the fraction thereof, or the compound isolated from the same of the present invention can be effectively used for the prevention or treatment of atopy.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: August 30, 2016
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Jae Wha Kim, Kyung Seop Ahn, Ho Bum Kang, Sei Ryang Oh, Jae Jong Go, Joo Heon Kim, Jang Mi Sun, Jae Sung Song, Hyun Woo Oh, Da Jung Ji
  • COMPOSITION CONTAINING LIGNAN COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER
    Publication number: 20160228402
    Abstract: The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition. Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.
    Type: Application
    Filed: November 8, 2013
    Publication date: August 11, 2016
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang OH, Yong Yeon CHO, Hyung Won RYU, Cheol Jung LEE, Hye Suk LEE, Doo Young KIM, Jung Hee KIM, Kyung Seop AHN, Mee Hyun LEE, Hyeong Kyu LEE
  • Nanopositioning substrate preparation apparatus and preparation method using dip pen nanolithography with a single tip or multiple tips using atomic force microscope (AFM)
    Patent number: 9403180
    Abstract: Provided are method and apparatus to nanoposition ink, the apparatus including: a substrate; a pattern index; an atomic force microscope (AMF) tip configured to form a pattern on the pattern index; a first ink reservoir including a first ink; a second ink reservoir including a second ink; a first cleaning portion configured to remove the first ink from the AMF tip; a second washing portion configured to remove the second ink from the AMF tip; a position determining portion configured to interact with the AMF tip; an electrode connection portion configured to apply a voltage to the position determining portion, in order to determine a position of the AMF tip when the AMF tip interacts with the position determining portion. The AMF tip is configured to configured to interact with the position determining portion, prior to forming the pattern using the first and second inks.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: August 2, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Tai-Hwan Ha, Jee-Eun Park
  • METHIONYL TRNA SYNTHETASE FOR BIOSYNTHESIS OF PHOTOMETHIONINE-LABELED PROTEIN AND METHOD FOR PREPARING PHOTOACTIVE PROTEIN G VARIANT USING SAME
    Publication number: 20160200777
    Abstract: Provided is a methionyl tRNA synthase (MRS) for the biosynthesis of a photomethionine-labeled protein and a method for preparing a photoactivatable protein G variant using same and, more particularly, to an MRS variant in which alanine at the position of 12th is substituted with glycine, leucine at the position of 13th by serine, tyrosine at the position of 260th by phenylalanine, isoleucine at the position of 297th by valine, and histidine at the position of 301st by leucine from the N-terminal of the amino acid sequence of a wild-type Escherichia coli methionyl tRNA synthase. The MRS variant effectively confirms the biosynthesis of a photomethionine (pM)-labeled target protein and thus can be utilized for the biosynthesis of a pM-labeled target protein.
    Type: Application
    Filed: May 29, 2014
    Publication date: July 14, 2016
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Myung Kyu Lee, Bong Hyun Chung, Jeong Hee Moon, Ga Bi Lee
  • Iodine-containing radial-shaped macromolecular compounds, preparation method thereof and contrast media compositions for CT comprising the same
    Patent number: 9387267
    Abstract: Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: July 12, 2016
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Yoonkyung Kim, Dong-Eog Kim, Hye-Youn Jung, Yun Hui Choe
  • Antiviral composition containing an or extract or a fraction thereof as an active ingredient
    Patent number: 9375456
    Abstract: The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-? (IFN-?) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: June 28, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Sei-Ryang Oh, Jae Wha Kim, Hyeong-Kyu Lee, Kyung Seop Ahn, Doo Young Kim, Jung Hee Kim, Jae Sung Song, Ho-Bum Kang, Inpyo Choi
  • MARKER FOR DETECTING PROLIFERATION AND TREATMENT CAPACITIES OF ADIPOSE-DERIVED STEM CELL CULTURED IN MEDIUM CONTAINING EGF OR BFGF, AND USE THEREOF
    Publication number: 20160178648
    Abstract: The present invention relates to: a composition for detecting a marker for detecting the proliferation capacity or treatment capacity of adipose-derived stem cells cultured in a medium containing epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF); and a detection method.
    Type: Application
    Filed: June 11, 2014
    Publication date: June 23, 2016
    Applicants: ANTEROGEN CO. LTD., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Kyung Sook CHUNG, Mi Hyung KIM
  • Drug conjugate comprising drug linked to human c-Met antibody, and use therefor
    Patent number: 9364556
    Abstract: The present invention relates to a drug conjugate comprising a cytotoxic drug conjugated to a c-Met specific human antibody. More specifically, the present invention relates to: a drug conjugate comprising a cytotoxic drug conjugated to a c-Met specific human antibody; a pharmaceutical composition for cancer treatment comprising the drug conjugate; and a cancer treatment method comprising a step in which the drug conjugate or pharmaceutical composition is administered to an individual.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: June 14, 2016
    Assignees: Korea Research Institute of Bioscience and Biotechnology, A&RT Co., Ltd.
    Inventors: Young Woo Park, Ki Won Jo, Sun Jeong Jo, Soon Sil Hyun, Jae Eun Park, Seok Ho Yoo, Myeoung Hee Jang, Hye Nan Kim, Chan Woong Park
  • Composition for enhancing immunity containing compounds represented by chemical formulas 1-8 or sophora flavescens extract as active ingredient
    Patent number: 9326968
    Abstract: The present invention relates to a composition for enhancing immunity through inducing the expression of interferon-? comprising a compound represented by Formulas 1 to 8, or Sophora flavescens extract comprising the same and fractions thereof as an active ingredient, a feed additive, feed composition, pharmaceutical composition, food composition, and over-the-counter (OTC) drug composition comprising the composition, and a method for enhancing immunity through administrating the composition. A composition for inducing the expression of interferon-?, comprising a compound represented by Formulas 1 to 8 of the present invention, Sophora flavescens extract comprising the same, or fractions thereof as active ingredient can prevent, alleviate, or treat the diseases that can be prevented or treated by increasing the expression of interferon.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: May 3, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Mun Chual Rho, Woo Song Lee, Kyoung Oh Cho, Su Jin Park, Young Bae Ryu, Young Min Kim, Seung Woong Lee, Ji Hak Jeong, Mi Hye Park, Jong Sun Chang
  • Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same
    Patent number: 9326940
    Abstract: The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: May 3, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Myung Kyu Lee, Abbas Mokhtarieh Amir, Bong Hyun Chung, Jong Min Choi
  • Immunochromatography detection sensor comprising optical waveguide and a detection method using the same
    Patent number: 9322824
    Abstract: The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of the optical waveguide and the colored conjugate in the band formed on the membrane, resulting in the absorbance signal from the colored conjugate being greatly amplified to improve the sample detection sensitivity, and to a detection method using the same.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: April 26, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Yong Beom Shin, Min Gon Kim, Byeong Woo Bae
  • Compounds as HIF-1alphainhibitors and manufacturing process thereof
    Patent number: 9315507
    Abstract: The present invention relates to novel compounds as HIF-1? inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1?, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1?-mediated VEGFA expression.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: April 19, 2016
    Assignees: Dongguk University Industry-Academic Cooperation Foundation, Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyeong Lee, Mi-Sun Won, Hwan-Mook Kim, Song-Kyu Park, Ki-Ho Lee, Chang-Woo Lee, Bo-Kyung Kim, Hyun-Seung Ban, Kyung-Sook Chung, Naik Ravi
  • Adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles
    Patent number: 9314520
    Abstract: The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: April 19, 2016
    Assignees: BIOLEADERS CORPORATION, KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, CHUNGBUK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION
    Inventors: Moon-Hee Sung, Haryoung Poo, Chul Joong Kim, Young-Ki Choi, Yong Taik Lim, Dong Jin Jeong, Sang-Mu Shim
  • Mannanase produced from sp. strain HY-13
    Patent number: 9307782
    Abstract: The present invention relates to a mannanase produced from Celluosimicrobium sp. strain HY-13 and more particularly to a highly active novel mannanase produced from Cellulosimicrobium sp. strain HY-13 as separated from an invertebrate. The mannanase produced from the said Cellulosimicrobium sp. strain HY-13 can be used in the decomposition of a mannan found in hemicellulose contained in grains and plants and in enhancing the utility value of a hydrolysate, which uses the decomposed mannan, for the transformation of biomass or as an animal feed material.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: April 12, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Ho-Yong Park, Kwang-Hee Son, Do Young Kim, Dong-Ha Shin, Han-Young Cho
  • Composition for Detecting Undifferentiated Human Pluripotent Stem Cell, Monoclonal Antibody 6-1 and Use Thereof
    Publication number: 20160097096
    Abstract: The present invention relates to a composition for detecting the undifferentiated human pluripotent stem cells comprising an agent useful for measuring the level of Desmoglein 2 (Dsg 2) mRNA or the protein thereof, a kit for detecting the undifferentiated human pluripotent stem cells comprising the said composition, a method for detecting the undifferentiated human pluripotent stem cells containing the step of measuring the level of Desmoglein 2 mRNA or the protein thereof, a method for evaluating the differentiation of human pluripotent stem cells and thereafter for separating the undifferentiated human pluripotent stem cells, a method for reducing the undifferentiated status of human pluripotent stem cells by inhibiting the expression or activation of Desmoglein 2, and a monoclonal antibody binding specifically to human Desmoglein 2.
    Type: Application
    Filed: July 22, 2015
    Publication date: April 7, 2016
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Jeong Ki MIN, Jongjin PARK, Kwang-Hee BAE, Sang Chul LEE, Yee Sook CHO
  • COMPOSITION COMPRISING (S)-(-)-BENPROPERINE FOR PREVENTING OR TREATING CANCER
    Publication number: 20160095845
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising (S)-(?)-benproperine or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for preventing or treating cancer using the same.
    Type: Application
    Filed: October 6, 2015
    Publication date: April 7, 2016
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Byoung Mog KWON, Dong Cho HAN, Sang Ku LEE, Yu Jin LEE, Yoon Jung JEON, Jiyeon CHOI, Ah-Rum HA, Young Min HAN