Abstract: The present invention relates to a novel pyrimidine derivative and a use thereof. The pyrimidine derivative has excellent MLK3 inhibitory activity and LRRK2 inhibitory activity and thus can be utilized in a pharmaceutical composition for preventing or treating cancers, virus infectious diseases, Parkinson's disease, nonalcoholic fatty liver disease, and tuberculosis.
Type:
Application
Filed:
December 16, 2020
Publication date:
November 2, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Abstract: A dehydrogenation method is provided that includes subjecting a first hydrogen storage body including compound including two or more N-heterocycloalkyl groups, and second hydrogen storage body including a compound including a substituted or unsubstituted cycloalkyl group and an N-heterocycloalkyl group, to a dehydrogenation reaction in the presence of a catalyst to produce hydrogen.
Type:
Application
Filed:
November 11, 2022
Publication date:
November 2, 2023
Applicants:
HYUNDAI MOTOR COMPANY, KIA CORPORATION, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Jihui Seo, Jaeyong Lee, Pyung Soon Kim, Jin Woo Choung, Yongwoo Kim, Soo Min Kim, Kwanyong Jeong, Jeong Jae Lee, Ji Hoon Park
Abstract: The present invention relates to a novel cathode buffer layer material, and an organic or organic/inorganic hybrid photoelectric device comprising same, and, if a novel compound of the present invention is applied to a cathode buffer layer of an organic photoelectric device such as organic solar cells, organic photodiode, colloidal quantum dot solar cell, and perovskite solar cell, a surface property of an electron transfer layer is improved via a high dipole moment of the novel compound, an electron can be easily extracted from a photoactive layer to a cathode electrode, and series resistance and leakage current can be reduced, thereby having a useful industrial effect, as performance of the organic or organic/inorganic hybrid photoelectric device being manufactured, such as an organic solar cell, organic photodiode, colloidal quantum dot solar cell, and perovskite solar cell, can be significantly improved.
Type:
Grant
Filed:
April 22, 2019
Date of Patent:
October 31, 2023
Assignee:
Korea Research Institute of Chemical Technology
Inventors:
Sung Cheol Yoon, Chang Jin Lee, Jaemin Lee, Seung Hun Eom, Seung Hoon Lee, Ju Hyoung Jung
Abstract: The present disclosure relates to a catalyst for preparing 1,2-pentanediol from furfural and/or furfuryl alcohol, and more particularly to a catalyst, which is configured such that a catalytically active metal containing both at least one transition metal and tin (Sn) is supported on a basic support and is capable of increasing reaction selectivity for 1,2-pentanediol, and a method of preparing 1,2-pentanediol using the same.
Type:
Grant
Filed:
July 4, 2019
Date of Patent:
October 31, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Young Kyu Hwang, Do Young Hong, Jaesung Kwak, Pandharinath Pravin Upare, Dong Won Hwang, Jung Ho Lee, Jong-San Chang, Joung-mo Cho, U Hwang Lee, Kyung Ho Cho, Su Kyung Lee
Abstract: There is provided a method for producing trifluoroamine oxide. The method includes a step of preparing an intermediate product by simultaneously providing and reacting nitrogen trifluoride and nitrous oxide under the presence of a SbF5 reaction catalyst; and a step of producing trifluoroamine oxide by reacting the intermediate product with potassium fluoride. The step of reacting the intermediate product with potassium fluoride is performed under atmospheric pressure and room temperature.
Type:
Application
Filed:
September 23, 2021
Publication date:
October 19, 2023
Applicants:
SK SPECIALTY CO., LTD, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Junghun KWAK, Byunghyang KWON, Yongjun CHO, Injoon PARK, Shinhong YUK, Bongjun CHANG, Hongsuk KANG, Eunho SOHN, Sanggoo LEE, Jihoon BAIK, Juhyeon KIM, Myoungsook LEE, Wonwook SO
Abstract: The present invention relates to an electrode for a biosensor for NADH measurement and a manufacturing method therefor. An electrode manufactured by the method according to the present invention enjoys the advantages of stabilizing current flow during an electric polymerization reaction, making the contact angle of the modified material remarkably small to increase the efficiency of surface modification, and being reusable several times. In addition, when applied to a biosensor for NADH measurement, the electrode of the present invention maintains sensitivity and selectivity at a high level without interference and thus easily measures a target of interest even in blood or serum that necessarily requires a pretreatment process due to the existence of a trace amount of a material to be measured.
Type:
Grant
Filed:
December 28, 2018
Date of Patent:
October 10, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Abstract: The present invention relates to a novel cathode buffer layer material and an organic photoelectric device including the same. When the novel compound of the present invention is applied to a cathode buffer layer of an organic photoelectric device, for example, an organic solar cell or an organic photodiode, there is an effect in which the surface characteristics of an electron transport layer are improved through the high dipole moment of the novel compound to thereby facilitate electron extraction from a photoactive layer to a cathode electrode and to reduce series resistance and leakage current, and accordingly, the performance of an organic optoelectronic device (organic solar cell, organic photodiode, etc.) to be manufactured can be remarkably improved, which is industrially advantageous.
Type:
Grant
Filed:
July 17, 2018
Date of Patent:
September 26, 2023
Assignee:
Korea Research Institute of Chemical Technology
Inventors:
Sung Cheol Yoon, Chang Jin Lee, Jaemin Lee, Seung Hun Eom
Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
Type:
Grant
Filed:
September 7, 2022
Date of Patent:
September 26, 2023
Assignees:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
Inventors:
Sung Youn Chang, Hyuk Lee, Ki Young Kim, Bum Tae Kim, Sung Soo Kim, Seong Hwan Kim, Hwan Jung Lim, Jung Nyoung Heo, Sang Joon Shin, Sang Youn Park
Abstract: Provided is a method for synthesizing bipyridine that includes performing a dimerization reaction of a reactant including a piperidine-based compound, a pyridine-based compound, or a mixture thereof in the presence of a catalyst in which an active metal is supported on a composite metal oxide support including silica (SiO2) and alumina (AI2O3).
Type:
Application
Filed:
August 22, 2022
Publication date:
September 21, 2023
Applicants:
HYUNDAI MOTOR COMPANY, KIA CORPORATION, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Jihui Seo, Jaeyong Lee, Pyung Soon Kim, Jin Woo Choung, Yongwoo Kim, Ji Hoon Park, Soo Min Kim, Jeong Jae Lee, Kwanyong Jeong
Abstract: A low-temperature dehydrogenation method includes a dehydrogenation reaction of a reactant including a piperidine-based compound substituted with one or more alkyl groups. The dehydrogenation reaction takes place in the presence of a catalyst including an active metal. The active metal includes platinum (Pt), palladium (Pd), or a mixture thereof that is supported on a carrier including a composite metal oxide having alumina (Al2O3) and an additional metal oxide different from alumina, at a low temperature of 150° C. to 250° C., to produce hydrogen.
Type:
Application
Filed:
November 7, 2022
Publication date:
September 21, 2023
Applicants:
HYUNDAI MOTOR COMPANY, KIA CORPORATION, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Jihui Seo, Jaeyong Lee, Pyung Soon Kim, Jin Woo Choung, Yongwoo Kim, Ji Hoon Park, Soo Min Kim, Jeong Jae Lee, Kwanyong Jeong
Abstract: A biodegradable composite material which is produced by polymerizing a mixture of an aqueous dispersion of a natural polymer nanofiber including any one or more of a chitin nanofiber and a cellulose nanofiber, a dicarboxylic acid or a derivative thereof, and a diol. The biodegradable composite material has excellent biodegradable and mechanical properties.
Type:
Grant
Filed:
May 28, 2020
Date of Patent:
September 12, 2023
Assignee:
Korea Research Institute of Chemical Technology
Inventors:
Sung Yeon Hwang, Jeyoung Park, Dong Yeop Oh, Tae Ho Kim, Si Gyeong Lee, Myung Suk Shin, Jong Geon Jegal
Abstract: The present invention relates to a method for preparing a perfluorodialkyl ether, comprising the steps of: (A) preparing a perfluorodialkyl ether from a compound represented by Formula 1 in the presence of a metal fluoride; and (B) isolating the perfluorodialkyl ether, and to an apparatus for preparing perfluorodialkyl ether, comprising: a reactor for preparing a perfluorodialkyl ether from a compound represented by Formula 1 in the presence of a metal fluoride; a reactant supplier for introducing the compound represented by Formula 1 into the reactor; and a discharge unit for discharging the perfluorodialkyl ether from the upper portion of the reactor.
Type:
Application
Filed:
July 26, 2021
Publication date:
September 7, 2023
Applicants:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTE
Inventors:
Sang Goo LEE, In Joon PARK, Won Wook SO, Shin Hong YOOK, Hong Suk KANG, Eun Ho SOHN, Ki Dong SONG, Yeon Ho OH, Hyun Jae JANG
Abstract: The present disclosure relates to a composite membrane in which a rubbery polymer is introduced into a gutter layer to suppress the physical aging of the highly permeable composite membrane, and more particularly, to a composite membrane comprising a porous support layer; a gutter layer on the porous support layer; and an active layer on the gutter layer, wherein the gutter layer comprises a blend of poly(l-trimethlsilyl-l-propyne) (PTMSP) and a rubbery polymer and a method for preparing the same. The composite membrane according to the present disclosure has high permeation performance and a remarkable decline in physical aging leading to a decrease in permeability over time and thus has very high industrial applicability.
Type:
Application
Filed:
July 15, 2021
Publication date:
August 31, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Su Young MOON, Jong Myeong LEE, Bong Jun CHANG, Chang In KONG, Jae-Hyeok LEE
Abstract: The techniques disclosed in the present specification relate to devices, systems, and methods using the same that generate cigarette smoke and then separate and collect substances of the cigarette smoke generated into particulate and gaseous substances for the preparation of a whole cigarette smoke condensate, which may comprise: a cigarette mount on which one or more cigarettes are mounted; an automatic ignition device for igniting the one or more cigarettes; a cigarette smoke collection unit for collecting substances of cigarette smoke generated from the ignited one or more cigarettes; one or more cigarette smoke intake lines configured to suck the cigarette smoke; one or more cigarette smoke exhaust lines configured to discharge the cigarette smoke; and one or more collection unit connecting lines connected to the cigarette smoke collection unit.
Type:
Grant
Filed:
June 3, 2021
Date of Patent:
August 15, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Yong-Hyun Kim, Sung-Hwan Kim, Min-Seok Kim
Abstract: The present disclosure relates to a composition for preventing, alleviating or treating pruritus and/or atopy using an N-acetylamino acid or an N-acylamino acid having almost no side effects on the human body. Also, the present disclosure relates to a cosmetic composition for moisturizing skin or soothing skin. The composition of the present disclosure may be utilized to ameliorate a problematic skin condition caused by various causes, or to safely and effectively alleviate or treat pruritus and/or atopy without concern about side effects.
Type:
Application
Filed:
March 23, 2023
Publication date:
August 10, 2023
Applicants:
STEMDR INC., INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Abstract: The present invention relates to the development of a composition for the treatment of novel SARS-coronavirus-2 infection. The drug efficacy was evaluated through CPE (Cytopathic Effect)-based assay method that measures how long the cells survive by infecting SARS-CoV-2 after receiving a drug library previously approved as a treatment for a specific disease from the Korea Chemical Bank and treating Vero cells with the drug, and an image-based assay that measures how much virus is reduced in infected cells. Through this, 16 kinds of drugs effective in the treatment of SARS-CoV-2 were re-positioned.
Type:
Application
Filed:
June 8, 2021
Publication date:
August 10, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Soo Bong HAN, Jin Soo SHIN, Mee Hyein KIM, Eunhye JUNG, Ye Jin JANG, Hyuk LEE, Myoungkyu LEE, Dongsu KIM, Chang Soo YUN, Young Sik JUNG
Abstract: The present invention relates to a polar functional group-partially introduced polymer, a preparation method therefor, and an organic electronic element adopting the same. The organic electronic element of the present invention has excellent photoelectric conversion efficiency and stability and is very advantageous in commercialization, by adopting the polar functional group-partially introduced polymer of the present invention.
Type:
Grant
Filed:
November 26, 2018
Date of Patent:
August 1, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Chang Eun Song, Won Suk Shin, Sang Jin Moon, Jong Cheol Lee, Sang Kyu Lee, Hang Ken Lee, Vu Van Doan, Shafket Rasool
Abstract: A clearing pretreatment method of a biological sample having a size of at most 1 mm, that is, a spheroid or organoid, according to the present invention uses a phosphate-buffered saline (PBS) rather than a conventional sucrose solution as a pretreatment solution, thus solving the problem in which the spheroid or organoid floats above the surface of water due to the density difference such that the structure of the sample is damaged. Therefore, there is an effect in that the spheroid or organoid can be transparentized while maintaining the original shape thereof, thus making it possible to image deep parts.
Type:
Application
Filed:
May 28, 2021
Publication date:
July 27, 2023
Applicants:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
Sun-Hyun PARK, Ki-Suk KIM, Jae-Meun LEE, Jae-Hyeok LEE, Seong-Hoon PARK, Ji Yeoun LEE, Jinju PARK
Abstract: The present invention relates to an ammonia decomposition catalyst that converts ammonia into hydrogen and nitrogen. The catalyst includes ruthenium (Ru) as an active catalytic component and a composite oxide solid solution (LaxCe1-xOy) including lanthanum oxide and cerium oxide as a catalyst support. The present invention also relates to an ammonia decomposition method using the catalyst and a hydrogen production method using the catalyst.
Type:
Application
Filed:
January 27, 2021
Publication date:
July 27, 2023
Applicant:
Korea Research Institute of Chemical Technology
Inventors:
Ho Jeong Chae, Young-min Kim, Thien An Le, Jeong-Rang Kim, Tae Wan Kim, Youjin Lee, Su Un Lee
Abstract: The present invention relates to a novel pyrimidine derivative, and a composition for preventing or treating neurodegenerative diseases and cancer, comprising same, the pyrimidine derivative having a LRRK2 protein inhibitory activity, and effectively passing through a blood-brain barrier (BBB) so as to be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancer.
Type:
Application
Filed:
March 12, 2021
Publication date:
July 13, 2023
Applicants:
WHAN IN PHARMACEUTICAL CO., LTD., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Ge Hyeong LEE, Jee Yeon SEO, Jeong Heon YU, In Hae YE, Ho Chul SHIN, Jee Hee SUH, Seong Hwan KIM, Jin Sook SONG, Seong Hyeon SIM, Chong Hak CHAE, Hee Yeon KANG, Ji Hun LEE, Keon Ha HWANG