Abstract: The present disclosure relates to the use of silica-forming peptides (SFPs) Volp1 and Salp1 for protein fusion tags for protein purification, silica formation and self-encapsulation, and controlled release of biomolecules. After preparing a fusion protein containing the Volp1 or Salp1 peptide at the C-terminal of the protein, the adsorption conditions for silica (SiO2) surface were optimized. As a result, a high-purity fusion protein could be purified without an additional tag for purification. The fusion protein containing the silica-forming peptide was self-encapsulated and stably immobilized in the silica matrix through reaction with a silica precursor. The Volp1 and Salp1 peptides showed stronger adsorption ability for silica than the previously known R5 peptide. Using these characteristics, a silica complex wherein two proteins are encapsulated was prepared by mixing the R5 fusion protein with the Volp1 or Salp1 fusion protein.

Abstract: The present invention relates to a temperature-sensitive composite and a method for preparing the same. The temperature-sensitive composite according to the present invention is maintained in a liquid state at room temperature and solidified at the time of delivery in the body, and shows remarkably excellent improvement in mechanical properties compared with an existing temperature-sensitive polymer composite, and as a result, the temperature-sensitive composite can promote the stability of a drug delivery system in the body and the sustainment of drug release.

Abstract: A stretchable multimode sensor and a method of fabricating the same are provided. The stretchable multimode sensor may include a substrate which is formed of a flexible material and includes a pressure sensor area, an optical sensor area, a temperature sensor area and a switching element area, a pressure sensor which is disposed on the pressure sensor area and includes an amorphous metal, an optical sensor which is disposed on the optical sensor area and includes an amorphous metal, and a temperature sensor which is disposed on the temperature sensor area and includes an amorphous metal, and a switching element which is disposed on the switching element area and includes an amorphous metal.

Abstract: A stretchable substrate according to an embodiment of the present invention comprises a first modulus region which has a first modulus, a second modulus region which is located in a plane direction with respect to the first modulus region and has a second modulus higher than the first modulus, and a third modulus region which is located between the first modulus region and the second modulus region and has an interface modulus which gradually changes between the first modulus and the second modulus, wherein the interface modulus of the third modulus region may be constant in the thickness direction thereof.

Abstract: Disclosed is a stochastic time-to-digital converter, which includes a first arbiter cell that compares a timing of a reference signal and a timing of an input signal based on a voltage selected by a first selection signal from among a first voltage or a second voltage and outputs a first comparison result, a second arbiter cell that compares the timing of the reference signal with the timing of the input signal based on a voltage selected by a second selection signal from among the first voltage or the second voltage and outputs a second comparison result, and a binary converter that calculates a phase difference between the reference signal and the input signal based on the first comparison result and the second comparison result.

Abstract: Disclosed is a method and system for monitoring a separation anxiety of a pet that may recognize an activity of the pet using a support vector machine (SVM) based on pet-related data acquired from a sensor, and may determine whether the pet is in a separation anxiety state by analyzing input data that is the recognized activity of the pet using a complex event processing (CEP).

Abstract: The present invention relates to anovel quinolinone derivative compound that regulates intracellular signal transduction mediated by TSLP and IL-33 to exhibit efficacy in preventing or treating allergic diseases such as asthma or atopic dermatitis. The quinolinone derivative compound of the present invention can effectively suppress inflammatory responses of allergic diseases such as asthma or atopic dermatitis. The present invention also relates to a pharmaceutical composition including the quinolinone derivative compound. The pharmaceutical composition of the present invention can be used to fundamentally prevent or treat various allergic and asthmatic diseases.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating allergic diseases such as asthma or atopy including baicalein as an active ingredient. Baicalein is capable of regulating thymic stromal lymphopoietin-mediated signal transduction. The pharmaceutical composition of the present invention can effectively suppress inflammatory responses of allergic or asthmatic diseases due to the presence of baicalein extracted from Scutellariae Radix that regulates TSLP-mediated intracellular signal transduction to inhibit intracellular phosphorylation of STATS and inhibit the binding of TSLP to TSLPR. In addition, the pharmaceutical composition of the present invention may further include one or more compounds having synergistic effects with baicalein. In this case, the pharmaceutical composition can more effectively suppress inflammatory responses of allergic diseases such as asthma or atopy.

Abstract: Provided is a heavy metal detecting sensor. The heavy metal detecting sensor includes an electrode and a plurality of amyloid fibers disposed on the electrode, wherein an amount of a redox current of the electrode decreases when the plurality of amyloid fibers react with heavy metal ions.

Abstract: A stretchable display according to one embodiment of the present invention comprises: a hybrid stretchable substrate divided into a low stretchable region and a high stretchable region having a modulus lower than that of the low stretchable region; a driving element layer including a driving element on the low stretchable region so as to control a light emitting layer, and wiring on the high stretchable region so as to be electrically connected to a part of the driving element to apply an electrical signal; and the light emitting layer provided on the driving element layer, and electrically connected to the driving element layer to emit light, wherein, between the driving element and the wiring, the wiring can overlap a stretchable mask pattern having a shape corresponding to either the low stretchable region or high stretchable region.

Abstract: Disclosed is a prostate cancer diagnostic biomarker composition including, as an active ingredient, at least one kynurenine pathway metabolite selected from kynurenine and anthranilate. Also disclosed are a prostate cancer diagnostic composition including an agent capable of measuring the level of the biomarker and a prostate cancer diagnostic kit including the prostate cancer diagnostic composition. The use of the prostate cancer diagnostic biomarker composition can significantly improve the accuracy of prostate cancer diagnosis as an alternative or supplement to the use of PSA levels for prostate cancer diagnosis according to the prior art, which has difficulty in ensuring accurate diagnosis. Therefore, the biomarker composition can be widely used in a variety of industrial applications, including medical applications.

Abstract: Provided is an aluminum ion detector. The aluminum ion detector may include apple extracts having a predetermined concentration, and metal nano particles coupled to the apple extracts.

Abstract: The present invention relates to an exosome-based nanoparticle composite and a method for preparing the same. More specifically, the present invention relates to an exosome-based nanoparticle composite that uses exosomes isolated from cells and a biocompatible polymer to achieve improved in vivo stability and redispersibility, and a method for preparing the nanoparticle composite. The nanoparticle composite of the present invention exhibits a stable and continuous drug release pattern irrespective of the solubility of the drug and has excellent tumor targeting due to its good in vivo stability and improved redispersibility in aqueous solution.

Abstract: A display device according to an embodiment of the present invention comprises: a first substrate to which external light is applied; a first and a second control electrode disposed on the first substrate, the second control electrode being spaced apart from the first control electrode; an insulating film disposed on the first and the second control electrode; a first and a second contact electrode formed on the insulation film, wherein the first contact electrode at least partially overlaps the first control electrode, and the second contact electrode is spaced apart from the first contact electrode and at least partially overlaps the second control electrode; a shuttering operation body moving between the first and the second contact electrode so as to transmit or block light; a second substrate opposite to the first substrate; and a quantum dot film disposed on the first or the second substrate and adjusting the wavelength of light passing through the shuttering operation body.

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

Abstract: Disclosed is a high-speed and low-power pipelined analog-digital converter (ADC) using a dynamic reference voltage and a 2-stage S/H. The pipelined ADC includes a 2-stage sample-and-hold (S/H) configured to secure a conversion time corresponding to a clock cycle per stage and to apply only a buffer to an input signal path, a reference voltage generator configured to receive the output of the D flip-flop of a previous stage as an input signal and to generate a required reference voltage during a half cycle of a sample frequency, and a comparator configured to include a linear transconductor (LT), a rail-to-rail latch (R2R) and a D flip-flop and to generate the output of the ADC and input to the reference voltage generator of a next stage for generating a reference voltage using the output of the D flip-flop.

Abstract: Disclosed is a method for detecting toxic metal ions in a sample. The method includes: a) preparing a solution of organic acid-bound gold nanoparticles; b) adding a sample containing toxic metal ions to the solution prepared in a) to allow the gold nanoparticles to aggregate; c) dropping the reaction solution obtained in b) onto a silicon substrate and drying the reaction solution such that the gold nanoparticle aggregates are immobilized on the silicon substrate; and d) analyzing the characteristics of the gold nanoparticles immobilized on the silicon substrate. The method enables the detection of even a trace amount of toxic metal ions in a sample with high sensitivity. Therefore, the method can be applied to the management of water quality in food service providers and hospitals, the measurement of contaminants in water supply and drainage systems, and the management of industrial wastewater.

Abstract: Provided herein are a probe capable of simultaneously detecting a virus and treating virus-infected cells, a composition for detecting a virus, which comprises the probe, a composition for treating a virus, which comprises the probe, and a method of detecting a virus or treating a viral infection by using the same. According to the present disclosure, it is possible to simultaneously perform diagnosis by virus detection and treatment of virus-infected cells, and in particular, diagnosis and treatment may be simultaneously performed on various types of viruses by varying the type of molecular beacon, and thus may be usefully applied to virus diagnosis and treatment fields, which require rapid diagnosis and treatment, and the spread of viral infections may be effectively prevented. In addition, the probe of the present disclosure has excellent stability and excellent detection sensitivity, and thus enables the detection of even a very low amount of a target at the pmole level.

Abstract: A stretchable multimode sensor and a method of fabricating the same are provided. The stretchable multimode sensor may include a substrate which is formed of a flexible material and includes a pressure sensor area, an optical sensor area, a temperature sensor area and a switching element area, a pressure sensor which is disposed on the pressure sensor area and includes an amorphous metal, an optical sensor which is disposed on the optical sensor area and includes an amorphous metal, and a temperature sensor which is disposed on the temperature sensor area and includes an amorphous metal, and a switching element which is disposed on the switching element area and includes an amorphous metal.

Abstract: The present invention relates to a method for manufacturing a nonvolatile memory thin film device by using a neutral particle beam generation apparatus. The present invention solves the problem that substrates such as glass and a plastic film may not be used for manufacturing the memory thin film device due to the high temperature heat treatment process for a long time, in the existing method for manufacturing the thin film device having the nonvolatile memory function by forming the mobile proton layer.