Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
Type:
Grant
Filed:
April 7, 2009
Date of Patent:
July 19, 2011
Assignee:
Koronis Pharmaceuticals, Incorporated
Inventors:
Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides isoguanosine nucleosides and derivatives thereof as well a method of increasing the mutation rate of a virus such as bovine viral diarrhea virus (BVDV) and hepatitis C virus (HCV).
Type:
Grant
Filed:
February 13, 2006
Date of Patent:
January 19, 2010
Assignee:
Koronis Pharmaceuticals, Incorporated
Inventors:
Ling Li, Alexander Gall, Richard Daifuku
Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
Type:
Grant
Filed:
December 27, 2006
Date of Patent:
September 15, 2009
Assignee:
Koronis Pharmaceuticals, Incorporated
Inventors:
Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
Type:
Application
Filed:
April 7, 2009
Publication date:
August 20, 2009
Applicant:
Koronis Pharmaceuticals, Incorporated
Inventors:
Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
Type:
Application
Filed:
March 30, 2009
Publication date:
July 30, 2009
Applicant:
Koronis Pharmaceuticals, Incorporated
Inventors:
Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
Type:
Grant
Filed:
March 31, 2004
Date of Patent:
July 17, 2007
Assignee:
Koronis Pharmaceuticals, Incorporated
Inventors:
Richard Daifuku, Alexander Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris
Abstract: The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides 5-aldehydo-uracil nucleosides and derivatives thereof, and methods of administration thereof to increase the virus mutation rate in a virally infected cell.
Type:
Grant
Filed:
August 21, 2002
Date of Patent:
July 17, 2007
Assignee:
Koronis Pharmaceuticals, Incorporated
Inventors:
Ling Li, Alexander Gall, Richard Daifuku
Abstract: The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
Type:
Application
Filed:
March 31, 2004
Publication date:
January 20, 2005
Applicant:
Koronis Pharmaceuticals, Incorporated
Inventors:
Richard Daifuku, Alexande Gall, Dmitri Sergueev, Dina Sologub, Kevin Harris