Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result.
Type:
Application
Filed:
May 3, 2023
Publication date:
October 26, 2023
Applicant:
Korro Bio, Inc.
Inventors:
Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
Type:
Application
Filed:
May 9, 2023
Publication date:
October 19, 2023
Applicant:
Korro Bio, Inc.
Inventors:
Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
Abstract: The present invention relates to methods and compositions for editing an ABCA4 polynucleotide, e.g., an ABCA4 polynucleotide comprising a SNP associated with Stargardt Disease, type 1. The invention also relates to methods and compositions for treating or preventing Stargardt Disease, type 1, in a subject.
Type:
Application
Filed:
May 14, 2021
Publication date:
June 8, 2023
Applicant:
Korro Bio, Inc.
Inventors:
Andrew Fraley, Mallikarjuna Reddy Putta, Matthew Jarpe
Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
Type:
Application
Filed:
September 15, 2022
Publication date:
May 11, 2023
Applicant:
Korro Bio, Inc.
Inventors:
Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result,
Type:
Application
Filed:
August 5, 2022
Publication date:
April 6, 2023
Applicant:
Korro Bio, Inc.
Inventors:
Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
Type:
Grant
Filed:
January 22, 2020
Date of Patent:
October 25, 2022
Assignee:
Korro Bio, Inc.
Inventors:
Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
Abstract: The present disclosure features useful compositions and methods to recruit RNA editing enzymes and treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
Type:
Application
Filed:
March 24, 2022
Publication date:
September 29, 2022
Applicant:
Korro Bio, Inc.
Inventors:
Andrew Fraley, Mallikarjuna Reddy Putta
Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
Type:
Grant
Filed:
January 22, 2020
Date of Patent:
September 27, 2022
Assignee:
Korro Bio, Inc.
Inventors:
Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
Abstract: The present invention relates to methods and compositions for editing a SERPINA1 polynucleotide, e.g., a SERPINA1 polynucleotide comprising a SNP associated with alpha 1 antitrypsin deficiency. The invention also relates to methods and compositions for treating or preventing alpha 1 antitrypsin deficiency in a subject.
Type:
Application
Filed:
May 27, 2021
Publication date:
December 9, 2021
Applicant:
Korro Bio, Inc.
Inventors:
Steven Robinette, Andrew Fraley, Mallikarjuna Reddy Putta