Patents Assigned to Kosan Biosciences Incorporated
  • Geldanamycin compounds and method of use
    Publication number: 20070270396
    Abstract: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
    Type: Application
    Filed: July 6, 2007
    Publication date: November 22, 2007
    Applicant: Kosan Biosciences Incorporated
    Inventors: Daniel Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang
  • Biosynthetic gene cluster for leptomycins
    Patent number: 7288396
    Abstract: Polypeptides and domains of leptomycin polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other polyketides using the nucleic acids encoding leptomycin polyketide synthase domains or modifying enzymes.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: October 30, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Zhihao Hu, Ralph Reid
  • Biosynthetic gene cluster for jerangolids
    Patent number: 7285405
    Abstract: Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described, as are methods to prepare jerangolid analogs and other polyketides using the polynucleotides encoding jerangolid synthase domains or modifying enzymes.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: October 23, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Christopher D. Reeves, Ralph C. Reid
  • Geldanamycin compounds and method of use
    Patent number: 7259156
    Abstract: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: August 21, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Daniel V. Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang
  • Sixteen-member macrolide antiinfective agents
    Patent number: 7247617
    Abstract: Sixteen membered macrolide anti-infective agents having a structure according to formula I where R1, R2, R3, R4, R5, and R6 are as defined herein, and related compounds are disclosed.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: July 24, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Hong Fu, Leonard Katz, David C. Myles
  • Secondary metabolite congener distribution modulation
    Patent number: 7220560
    Abstract: The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distribution.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: May 22, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Peter J. Licari, Bryan Julien, Scott Frykman, Hiroko Tsuruta
  • Synthetic discodermolide analogs
    Patent number: 7214708
    Abstract: Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A where RA through RE and XA are as defined herein.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: May 8, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Kurt F. Sundermann, Simon James Shaw, Daniel V. Santi
  • 9-Desoxoerythromycin compounds as prokinetic agents
    Patent number: 7211568
    Abstract: 9-Desoxoerythromycin compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: May 1, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Yaoquan Liu, Christopher Carreras, David C. Myles
  • Therapeutic formulations
    Patent number: 7091193
    Abstract: Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier, in particular such pharmaceutical compositions suitable for oral administration of an epothilone.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: August 15, 2006
    Assignee: Kosan biosciences Incorporated
    Inventors: Michael J. Sherrill, Robert G. Johnson, Jr.
  • Production of polyketides in bacteria and yeast
    Patent number: 7078233
    Abstract: Hybrid and novel polyketide synthases and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo ACP synthase.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: July 18, 2006
    Assignee: Kosan Biosciences Incorporated
    Inventors: Philip J. Barr, Daniel V. Santi, Gary W. Ashley, Rainer Ziermann
  • Epothilone compounds and methods for making the same
    Patent number: 7070964
    Abstract: The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by chemical synthesis.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: July 4, 2006
    Assignee: Kosan Biosciences Incorporated
    Inventors: Li Tang, Brian Metcalf, Leonard Katz, Gary Ashley
  • Method for production of polyketides
    Patent number: 7067290
    Abstract: A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to a value conducive to polyketide product stability, continuing the fermentation until a maximal titer of polyketide is achieved, and optionally extracting the polyketide from the culture.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: June 27, 2006
    Assignee: Kosan Biosciences Incorporated
    Inventors: Rika Regentin, Ruchir P. Desai
  • Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
    Patent number: 7049100
    Abstract: A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: May 23, 2006
    Assignee: Kosan Biosciences Incorporated
    Inventors: Daniel V. Santi, Qun Xue, Gary Ashley