Abstract: The object of the present invention is to provide a drug effective in treating or preventing osteoporosis. The present invention discloses a therapeutic or preventive drug for osteoporosis having a compound shown in the formula (1) (wherein R1 is an alkyloxy group with the carbon number of 1 to 4) or a pharmaceutically acceptable salt or ester of said compound in the formula (1) as an effective ingredient. In the compound of the formula (1), a substance in which R1 is CH3O is isotaxiresinol derived from Taxus yunanennsis and showed physiological activities in inhibiting bone resorption and improving bone formation.

Abstract: The object of the present invention is to provide a drug effective in treating or preventing osteoporosis. The present invention discloses a therapeutic or preventive drug for osteoporosis having a compound shown in the formula (1) (wherein R1 is an alkyloxy group with the carbon number of 1 to 4) or a pharmaceutically acceptable salt or ester of said compound in the formula (1) as an effective ingredient. In the compound of the formula (1), a substance in which R1 is CH3O is isotaxiresinol derived from Taxus yunanennsis and showed physiological activities in inhibiting bone resorption and improving bone formation.

Abstract: Drugs containing Taxiresinol, (7?R)-7?-Hydroxylariciresinol, Secoisolariciresinol and Isotaxiresinol, which are lignans contained in Hongdoushan, as the active ingredients. Drugs containing an extract, which is obtained by extracting a Hongdoushan plant with water and further extracting the obtained extract with an organic solvent, as the active ingredient. These drugs are useful particularly as a hypoglycemic agent, a liver protecting agent and an anticancer agent.