Patents Assigned to Kowa Co., Ltd.
  • NOVEL SPIROOXYINDOLE COMPOUNDS AND DRUGS CONTAINING SAME
    Publication number: 20080306102
    Abstract: A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11?-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11?-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).
    Type: Application
    Filed: May 16, 2008
    Publication date: December 11, 2008
    Applicant: KOWA CO., LTD.
    Inventors: Hisashi NAKASHIMA, Takaaki ARAKI, Takahisa OGAMINO, Yasushi KANEKO, Kazutoyo ABE, Kimiyuki SHIBUYA, Tadaaki OHGIYA
  • Reagent For Lead Assay
    Publication number: 20080299664
    Abstract: A reagent for lead assay whereby a lead concentration can be accurately assayed even if an analyte contains calcium ions, and a method for assaying the lead concentration using the reagent for lead assay are provided. The reagent for lead assay contains a porphyrin nucleus-incorporated polymer, which is obtained by radical copolymerization of a porphyrin compound with a vinylene monomer, and calcium ions.
    Type: Application
    Filed: July 28, 2005
    Publication date: December 4, 2008
    Applicant: Kowa Co., Ltd.
    Inventors: Takaharu Asano, Naoki Harada
  • Method for treating hyperlipidemia
    Patent number: 7459447
    Abstract: Provided is a method for treating hyperlipidemia or hypercholesterolemia, which comprises administering effective doses of ezetimibe and pitavastatin or a salt or lactone derivative thereof.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: December 2, 2008
    Assignees: Kowa Co., Ltd., Nissan Chemical Industries, Ltd.
    Inventors: Taro Aoki, Hiroyuki Yamazaki, Takashi Maejima
  • Method for producing cyclic diamine derivative or salt thereof
    Patent number: 7459552
    Abstract: The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme: (wherein Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent; X represents NH, S, or O; ring A represents a benzene ring or a pyridine ring, which may have a substituent; 1 represents an integer of 1 or 2; m represents an integer of 1 or 2; and n represents an integer of 1 to 6). The method enables synthesis of a cyclic diamine compound (3) or a salt thereof, which serves as an ACAT inhibitor, in an industrially useful manner.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: December 2, 2008
    Assignee: Kowa Co., Ltd.
    Inventors: Kimiyuki Shibuya, Tadaaki Ohgiya, Toru Miura
  • METHOD FOR TREATING AUTOIMMUNE DISEASES AND SCREENING METHOD FOR PREVENTIVE OR THERAPEUTIC AGENT FOR THE SAME
    Publication number: 20080213776
    Abstract: The present invention is directed to a method for treating autoimmune diseases comprising administering RBAp48 production suppressor or inhibitor; a screening method for a preventive or therapeutic agent for autoimmune diseases comprising determining RBAp48 production suppressing effect or inhibitory effect of a sample; a diagnosis agent or a diagnosing kit for autoimmune diseases containing a reagent for measuring RBAp48 level in gland tissue; and a diagnosis method for autoimmune diseases comprising measuring RBAp48 level in gland tissue.
    Type: Application
    Filed: December 31, 2007
    Publication date: September 4, 2008
    Applicant: Kowa Co., Ltd.
    Inventor: Yoshio HAYASHI
  • Process For Production of Optically Active Ppar-Activating Compound and Intermediate of the Same
    Publication number: 20080194833
    Abstract: A process for obtaining a compound (1) and an intermediate thereof in high yield and high optical yield is provided. A process for producing a compound (4), the process including reacting a compound (2) with a compound (3) in the presence of a base; and a process for producing a compound (1), the process including reacting a compound (2) with a compound (3) in the presence of a base to yield a compound (4) and then deesterifying the compound (4). wherein R represents an alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 8 carbon atoms.
    Type: Application
    Filed: February 23, 2006
    Publication date: August 14, 2008
    Applicant: Kowa Co., Ltd.
    Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
  • PTX3-GENE EXPRESSION INHIBITOR
    Publication number: 20080161348
    Abstract: A method for suppressing expression of PTX3 gene, which comprises administering an effective amount of a compound, which is represented by the following formula (1): wherein R1 represents an organic group, X represents —CH2CH2— or —CH?CH—, and R2 represents a hydrogen atom or an alkyl group, or a lactone derivative thereof, or a salt thereof. According to the present invention, a PTX3 gene expression suppressing method useful for the treatment of autoimmune diseases, especially rheumatoid arthritis can be provided.
    Type: Application
    Filed: March 30, 2007
    Publication date: July 3, 2008
    Applicants: KOWA CO., LTD., Nissan Chemical Industries, Ltd.
    Inventors: Shigeru MORIKAWA, Akashi Izumi, Takao Hamakubo, Tatsuhiko Kodama
  • NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
    Publication number: 20080119474
    Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.
    Type: Application
    Filed: January 14, 2008
    Publication date: May 22, 2008
    Applicant: Kowa Co., Ltd.
    Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
  • Metal Indicator
    Publication number: 20080057591
    Abstract: To provide a novel copper ion indicator which is less influenced by interfering metal ions and which is useful for measurement of copper ion within a wide concentration range. The invention provides a copper ion indicator containing a compound represented by formula (1): [wherein each of R1, R2, R3, R4, R5, and R6 represents a hydrogen atom or an alkali metal atom], and a method for determining copper ion concentration, which employs the indicator.
    Type: Application
    Filed: June 21, 2005
    Publication date: March 6, 2008
    Applicant: Kowa Co., Ltd.
    Inventors: Maria Sakairi, Katsumi Yabusaki
  • Therapeutic Agent for Hyperlipemia and Therapeutic Agent for Diabetes
    Publication number: 20080045567
    Abstract: A therapeutic agent for hyperlipidemia, diabetes, or hypertriglyceridemia containing an HMG-COA reductase inhibitor and a carboxylic acid compound represented by the following formula (1) or a salt thereof as effective ingredients. The therapeutic agent of the present invention has excellent effects of lowering blood cholesterol and blood triglycerides and is particularly useful for treatment of type IIb and type IV hyperlipidemia and treatment of diabetes and also useful for treatment of hypertriglyceridemia.
    Type: Application
    Filed: May 27, 2005
    Publication date: February 21, 2008
    Applicant: Kowa Co., Ltd
    Inventors: Taro Aoki, Junji Yamaguchi, Yusuke Sasaki
  • Method for Producing Cyclic Diamine Derivative
    Publication number: 20080045714
    Abstract: The present invention provides an industrially useful method for synthesizing a cyclic diamine derivative (4) or a salt thereof which serves as an ACAT inhibitor. A 2-hydroxyacetylaminopyridine compound represented by formula (1), and a method for producing a cyclic diamine derivative represented by formula (4) or a salt thereof from compound (1) through 1) Step A-1, 2) Steps B-1 and B-2, or 3) Steps B-1, B-3, and B-4.
    Type: Application
    Filed: June 30, 2005
    Publication date: February 21, 2008
    Applicants: Kowa Co., Ltd
    Inventors: Kimiyuki Shibuya, Ayako Tosaka
  • (S)-(-)-1-(4-Fluoroisoquinolin-5-Yl)Sulfonyl-2-Methyl-1,4-Homopiperazine Hydrochloride Dihydrate
    Publication number: 20080021018
    Abstract: The present invention is directed to (S)-(?)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate, to a method producing the dihydrate, and to a drug composition containing the dihydrate. The compound of the present invention has less hygroscopicity as compared with (S)-(?)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride anhydrous crystals and thus, exhibits excellent chemical stability.
    Type: Application
    Filed: November 29, 2005
    Publication date: January 24, 2008
    Applicants: Kowa Co., Ltd, D. Western Therapeutics Institute, Inc.
    Inventors: Takeshi Ohshima, Hiroyoshi Hidaka, Masami Shiratsuchi, Kazuhiro Onogi, Toshiaki Oda
  • Remedy for Glomerular Disease
    Publication number: 20080004320
    Abstract: Provided is a pharmaceutical composition useful for the prevention or therapy of glomerular diseases, in particular progressive chronic glomerular diseases. A preventive or therapeutic agent for a glomerular disease containing pyridoxamine or a salt thereof, and an angiotensin II receptor antagonist.
    Type: Application
    Filed: September 2, 2005
    Publication date: January 3, 2008
    Applicant: Kowa Co., Ltd.
    Inventor: Takashi Nakagawa
  • Benzofuran derivative
    Patent number: 7314877
    Abstract: The present invention is directed to a compound represented by formula (1): (wherein R1 represents an alkyl group which may have a substituent or an alkenyl group which may have a substituent; and each of R2 and R3 represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a dihydroxyalkyl group, or an alkynyl group, or R2 and R3 form, together with the nitrogen atom adjacent thereto, a nitrogen-containing saturated heterocyclic group which may have a substituent) and a drug composition containing the compound. The compound exhibits tumor necrosis factor (TNF-?) production inhibitory effect and improved absorption upon oral administration.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: January 1, 2008
    Assignee: Kowa Co., Ltd.
    Inventors: Seiichi Sato, Tomoyuki Koshi, Toshimi Mizoguchi, Kyoko Yasuoka, Natsuyo Kumai, Junko Totsuka, Masahiro Tamura, Masao Ohkuchi
  • PPAR-activating compound
    Patent number: 7301033
    Abstract: The present invention provides a compound selectively activating PPAR?, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): wherein A represents an oxygen atom, a nitrogen atom, or a sulfur atom; R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkyl-alkyl group, an aryl group, an aryl-alkyl group an aryl-oxy-alkyl group, a pyridyl-alkyl group, an alkoxycarbonyl-alkyl group, or a carboxy-alkyl group; X represents an oxygen atom, an NH group, or an S(O)n group (wherein n represents an integer of 0, 1, or 2); and m represents an integer from 2 to 8; or a salt thereof. The present invention also provides a medicament comprising the benzoic acid derivative or the salt thereof as an active ingredient.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: November 27, 2007
    Assignee: Kowa Co., Ltd.
    Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hajime Yamada, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe
  • Preventive and/or Therapeutic Medicine for Rheumatoid Arthritis
    Publication number: 20070270431
    Abstract: The present invention relates to a preventive and/or therapeutic medicine for rheumatoid arthritis containing 2-benzyl-5-(4-chlorophenyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one and methotrexate. The medicine of the present invention can be administered orally and exhibits suppressed side effects and excellent potency for suppression of arthritis.
    Type: Application
    Filed: September 29, 2005
    Publication date: November 22, 2007
    Applicant: Kowa Co., Ltd.
    Inventors: Yuichiro Tabunoki, Tomoyuki Koshi
  • PHOSPHORIC ESTER OF CELLULOSE DERIVATIVE AND METAL ADSORBENT COMPRISING THE SAME
    Publication number: 20070217974
    Abstract: The present invention is directed to a phosphoric ester of 2,3-dihydroxypropyl cellulose or 3-(2,3-dihydroxypropoxy)-2-hydroxypropyl cellulose, the cellulose having optionally undergone partial carbamidation, and to a metal absorbent employing the ester, and to a metal-absorbing apparatus employing the metal adsorbent. The cellulose derivative phosphoric ester serves as a metal adsorbent which exhibits high metal adsorption performance and metal adsorption rate per unit weight; has high mechanical strength; effectively soften water or a similar liquid; removes heavy metals from wastewater or a similar liquid at remarkably high efficiency; has excellent processability and can be formed into a variety of shapes and thus is applicable within a wide range: and can readily be reutilized.
    Type: Application
    Filed: September 26, 2005
    Publication date: September 20, 2007
    Applicant: Kowa Co., Ltd
    Inventors: Ming Lu, Katsumi Yabusaki
  • NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
    Publication number: 20070208025
    Abstract: This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (substituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients.
    Type: Application
    Filed: April 30, 2007
    Publication date: September 6, 2007
    Applicant: Kowa Co., Ltd.
    Inventors: Masao Ohkuchi, Yoshinori Kyotani, Hiromichi Shigyo, Tomoyuki Koshi, Takahiro Kitamura, Tadaaki Ohgiya, Takayuki Matsuda, Yukiyoshi Yamazaki, Natsuyo Kumai, Kyoko Kotaki, Hideo Yoshizaki, Yuriko Habata
  • Method for the treatment of diabetes
    Publication number: 20070179194
    Abstract: The present invention provides a method for treatment of diabetes, comprising administering a pitavastatin, and in combination therewith, enalapril or a salt thereof.
    Type: Application
    Filed: June 29, 2006
    Publication date: August 2, 2007
    Applicants: Kowa Co., Ltd., Nissan Chemical Industries, Ltd.
    Inventors: Taro Aoki, Katsutoshi Miyosawa
  • External preparation
    Publication number: 20070166360
    Abstract: An external preparation comprising following ingredients (A) and (B): (A) a compound represented by the following general formula (1) wherein R1 represents an organic residue having a cyclic structure that may have a substituent; R2 represents a hydrogen atom or a lower alkyl group; and X represents an ethylene group or an ethenylene group or a salt thereof, and (B) a monoterpene. The external preparation of the present invention is excellent in percutaneous absorbability.
    Type: Application
    Filed: March 30, 2005
    Publication date: July 19, 2007
    Applicants: Kowa Co., Ltd., Nissan Chemical Industries, Ltd.
    Inventors: Tatsuya Nakai, Makoto Kanebako