Patents Assigned to KRKA, Tovarna Zdravil, D.D.
  • PHARMACEUTICAL ORAL DOSAGE FORMS COMPRISING DABIGATRAN ETEXILATE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
    Publication number: 20130177652
    Abstract: The invention relates to pharmaceutical oral dosage forms of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate (dabigatran etexilate) and the pharmacologically acceptable salts thereof, in particular dabigatran etexilate methanesulfonate.
    Type: Application
    Filed: July 1, 2011
    Publication date: July 11, 2013
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
    Inventor: Vesna Kroselj
  • Salts of perindopril
    Patent number: 8470869
    Abstract: The present invention relates to new salts of perindopril, particularly to a new calcium salt and new amine salts of perindopril, to a process for their preparation and to a pharmaceutical formulations containing the new salts.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: June 25, 2013
    Assignee: KRKA, Tovarna Zdravil D.D. Novo Mesto
    Inventors: Marjo Merslavic, Sergeja Bombek, Urska Gojak, Matej Smrkolj, Rok Zupet
  • SOLID PHARMACEUTICAL COMPOSITION COMPRISING DONEPEZIL HYDROCHLORIDE
    Publication number: 20120283291
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: January 10, 2012
    Publication date: November 8, 2012
    Applicant: KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej J. Smrkolj
  • Pharmaceutical Formulation of Olanzapine
    Publication number: 20110319395
    Abstract: A pharmaceutical formulation comprising a homogeneous mixture of (a) olanzapine or a pharmaceutically acceptable salt thereof as an active ingredient, (b) a monosaccharide and/or oligosaccharide, (c) a polysaccharide and, optionally, further ingredients.
    Type: Application
    Filed: September 8, 2011
    Publication date: December 29, 2011
    Applicant: KRKA, Tovarna Zdravil, D.D.
    Inventors: Stanka PERC, Ivanka Banko, Ivanka Kolenc
  • Process for the preparation of levocetirizine and intermediates thereof
    Patent number: 8049011
    Abstract: The present invention describes a novel process for the preparation of levocetirizine and pharmaceutically acceptable acid addition salts thereof using diglycolic acid or derivatives thereof and new intermediates used in that process.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: November 1, 2011
    Assignee: KRKA, Tovarna Zdravil, D.D., Novo Mesto
    Inventors: Jaroslav Tihi, Rok Zupet, Anica Pecavar, Ivanka Kolenc, Darja Pavlin
  • Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form I
    Patent number: 7999106
    Abstract: Processes for the preparation of clopidogrel hydrogen sulfate of polymorphic form I are described which include use of specific solvents and process measures to avoid formation of undesired by-products.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: August 16, 2011
    Assignee: KRKA, Tovarna Zdravil, D.D., Novo Mesto
    Inventors: Haifang Mao, Hongguang Qian, Chen Chen
  • Isopropanol water solvate of olanzapine
    Patent number: 7906642
    Abstract: The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: March 15, 2011
    Assignee: KRKA, Tovarna Zdravil, D.D.
    Inventors: Berta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic
  • Sesquihydrate hydrochloride salt of irbesartan
    Patent number: 7875641
    Abstract: The present invention relates to sesquihydrate hydrochloride salt of irbesartan and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: January 25, 2011
    Assignee: KRKA Tovarna Zdravil, D.D., Novo Mesto
    Inventors: Silvo Zupancic, Matej Smrkolj, Renata Jaske
  • Solid pharmaceutical composition comprising donepezil hydrochloride
    Publication number: 20100317694
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: January 20, 2010
    Publication date: December 16, 2010
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D. , NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej Smrkolj
  • SALTS OF PERINDOPRIL
    Publication number: 20100298400
    Abstract: The present invention relates to new salts of perindopril, particularly to a new calcium salt and new amine salts of perindopril, to a process for their preparation and to a pharmaceutical formulations containing the new salts.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 25, 2010
    Applicant: KRKA, TOVARNA ZDRAVIL D.D. NOVO MESTO
    Inventors: Marjo Merslavic, Sergeja Bombek, Urska Gojak, Matej Smrkolj, Rok Zupet
  • SOLID DOSAGE FORMS COMPRISING ALISKIREN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
    Publication number: 20100143460
    Abstract: The present invention relates to a pharmaceutical formulation comprising aliskiren or a pharmaceutically acceptable salt thereof as the active ingredient, wherein the pharmaceutical formulation is present in a solid dosage form suitable for oral administration based on a granulate obtained by a hot-melt and solvent-free granulation process, and to a process for manufacturing a pharmaceutical formulation.
    Type: Application
    Filed: March 20, 2008
    Publication date: June 10, 2010
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
    Inventors: Franc Vrecer, Vida Skrabanja, Natalija Zajc, Urska Gojak
  • Processes for preparing venlafaxine and venlafaxine hydrochloride of form I
    Patent number: 7728173
    Abstract: A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very hight polymorphic purity are described.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: June 1, 2010
    Assignee: KRKA Tovarna Zdravil, d.d. Novo Mesto
    Inventor: Silvo Zupancic
  • Process For The Preparation Of Levocetirizine And Intermediates Thereof
    Publication number: 20100105908
    Abstract: The present invention describes a novel process for the preparation of levocetirizine and pharmaceutically acceptable acid addition salts thereof using diglycolic acid or derivatives thereof and new intermediates used in that process.
    Type: Application
    Filed: March 12, 2008
    Publication date: April 29, 2010
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO
    Inventors: Jaroslav Tihi, Rok Zupet, Anica Pecavar, Ivanka Kolenc, Darja Pavlin
  • Process for preparing lansoprazole
    Patent number: 7662968
    Abstract: The invention relates to a process for preparing lansoprazole. It is also directed to lansoprazole having a specific surface area and a pharmaceutical composition comprising lansoprazole.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: February 16, 2010
    Assignee: KRKA tovarna zdravil, d.d..
    Inventors: Berta Kotar-Jordan, Franc Vre{hacek over (c)}er, Mojca {hacek over (S)}egula {hacek over (Z)}akelj, Gregor Ritlop
  • Processes For The Preparation Of Clopidogrel Hydrogen Sulfate Polymorphic Form I
    Publication number: 20090234123
    Abstract: Processes for the preparation of clopidogrel hydrogen sulfate of polymorphic form I are described which include use of specific solvents and process measures to avoid formation of undesired by-products.
    Type: Application
    Filed: April 19, 2005
    Publication date: September 17, 2009
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D. NOVO MESTO
    Inventors: Haifang Mao, Hongguang Qian, Chen Chen
  • Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride
    Publication number: 20090130205
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: October 19, 2005
    Publication date: May 21, 2009
    Applicant: KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej Smrkolj
  • Process and intermediates for the preparation of olanzapine
    Patent number: 7498433
    Abstract: The invention provides an improved process for preparing Olanzapine as well as intermediates therefor.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: March 3, 2009
    Assignee: KRKA, Tovarna Zdravil, D.D.
    Inventors: Roman Lenarsic, Rok Zupet, Milena Benedik, Barbara Mohar, Anton {hacek over (S)}timac
  • Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride
    Publication number: 20080063705
    Abstract: The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process wherein the donepezil hydrochloride retains its polymorphic form and is therefore highly stable against conversion into other polymorphic forms.
    Type: Application
    Filed: October 19, 2005
    Publication date: March 13, 2008
    Applicant: KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO
    Inventors: Miha Vrbinc, Berta Kotar-Jordan, Rok Zupet, Matej Smrkolj
  • Isopropanol water solvate of olanzapine
    Publication number: 20070191348
    Abstract: The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Applicant: KRKA, Tovarna Zdravil, D.D.
    Inventors: Berta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic
  • Processes for preparing venlafaxine and venlafaxine hydrochloride of form I
    Publication number: 20070185354
    Abstract: A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very high polymorphic purity are described.
    Type: Application
    Filed: December 10, 2004
    Publication date: August 9, 2007
    Applicant: KRKA, TOVARNA ZDRAVIL, D.D. NOVO MESTO
    Inventor: Silvo Zupancic