Patents Assigned to KRKA
  • Patent number: 5350582
    Abstract: There is disclosed a stable formulation of enalapril salt of the formula I ##STR1## which is prepared in such manner that a compound of formula II ##STR2## is suspended in demineralized water and a stoichiometric amount of the corresponding sodium compound such as sodium carbonate, sodium hydrogen carbonate or sodium hydroxide is added thereto, to this enalapril sodium salt prepared in situ of the formula I ##STR3## formulating additives are added, the whole is homogenized and formulated.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: September 27, 1994
    Assignee: KRKA, tovarna zdravil, p.o.
    Inventors: Marjo Merslavic, Jozica Razen, Ales Rotar
  • Patent number: 4902509
    Abstract: There is suggested a new process for the isolation of chicken egg white cystatin from an aqueous solution of chicken egg white by means of heating to max. 80.degree. C., chromatography on carboxymethylated papain-Sepharose 4B, chromatography on Sephadex-G-50 and purification by means of ion exchange chromatrography of the Fast Protein Liquid Chromatrography type. There are further suggested new agents and methods of treating viral infections in living organisms, especially mammalian and avian picornaviral infections, by means of chicken egg white cystatin.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: February 20, 1990
    Assignee: KRKA, tovarna zdravil, n.sol.o.
    Inventors: Vito Turk, Joze Brzin
  • Patent number: 4826981
    Abstract: There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV ##STR1## wherein a novel compound of the formula I ##STR2## wherein R and R' may be the same or different and represent hydrogen, (C.sub.1 -C.sub.8)acyl or benzyl and R.sub.1 represents (C.sub.1 -C.sub.8)acyl, is hydrolyzed basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II ##STR3## with a compound A--CH.sub.2 --O--CH.sub.2 CH.sub.
    Type: Grant
    Filed: October 19, 1987
    Date of Patent: May 2, 1989
    Assignee: KRKA
    Inventors: Joze Kobe, Joze Gnidovec, Pavle Zupet
  • Patent number: 4701526
    Abstract: There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV ##STR1## wherein a novel compound of the formula I ##STR2## wherein R and R' may be the same or different and represent hydrogen, (C.sub.1 -C.sub.8)acyl or benzyl and R.sub.1 represents (C.sub.1 -C.sub.8)acyl, is hydrolyzed under mild basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II ##STR3## with a compound A--CH.sub.2 --O--CH.sub.2 CH.sub.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: October 20, 1987
    Assignee: KRKA, tovarna zdravil, n.sol.o.
    Inventors: Joze Kobe, Joze Gnidovec, Pavle Zupet
  • Patent number: 4551525
    Abstract: A process for preparing N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-di oxide which comprises reacting an alkyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide with P-phenyl-N,N'-di-2-pyridylphosphonium diamide.
    Type: Grant
    Filed: October 2, 1984
    Date of Patent: November 5, 1985
    Assignee: KRKA, tovarna zdravil, n.sol.o.
    Inventors: Natasa Zupancic, Boris Sket, Pavel Zupet, Marko Zupan
  • Patent number: 4187244
    Abstract: Process for the resolution of certain racemic .alpha.-aminonitriles into optically active enantiomers which includes treating the racemic .alpha.-aminonitriles with (-)-mandelic acid in an alkanol/C.sub.5-8 hydrocarbon mixture to obtain a racemic mixture of diastereoisomeric D and L salts of (-)-mandelic acid, macerating the salts with an alkanol/C.sub.5-8 hydrocarbon mixture; neutralizing the L-form; extracting the neutralized product; and converting it into a stable form.
    Type: Grant
    Filed: March 30, 1978
    Date of Patent: February 5, 1980
    Assignee: KRKA, Farmaceutika, Kemija, Kozmetika, zdravilisca in gostinstuo, Novo mesto, n.sd.o.
    Inventors: Marijan Hohnjec, Miha Japelj
  • Patent number: 4183865
    Abstract: Process for the resolution of certain racemic .alpha.-aminonitriles into optically active enantiomers which includes treating the racemic .alpha.-aminonitriles with (-)-dibenzoyl-tartaric acid in polar solvents to obtain a racemic mixture of diastereoisomeric D and L salts of (-)-dibenzoyl-tartaric acid, macerating the salts with dioxane, neutralizing the L-form, extracting the neutralized product, and converting it into a stable form.
    Type: Grant
    Filed: March 30, 1978
    Date of Patent: January 15, 1980
    Assignee: KRKA, farmacevtika, kemija, kozmetika, zdravilisca in gostinstvo, Novo mesto, n.sol.o.
    Inventors: Marijan Hohnjec, Miha Japelj