Patents Assigned to KRONOS BIO, INC.
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY
    Publication number: 20240132506
    Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):
    Type: Application
    Filed: November 3, 2023
    Publication date: April 25, 2024
    Applicant: Kronos Bio, Inc.
    Inventors: Peter MIKOCHIK, Joseph VACCA, David FREEMAN, Andrew S. TASKER
  • Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity
    Patent number: 11845754
    Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):
    Type: Grant
    Filed: September 15, 2021
    Date of Patent: December 19, 2023
    Assignee: Kronos Bio, Inc.
    Inventors: Peter Mikochik, Joseph Vacca, David Freeman, Andrew S. Tasker
  • Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Patent number: 11517570
    Abstract: The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: December 6, 2022
    Assignee: Kronos Bio, Inc.
    Inventors: Peter A. Blomgren, Kevin S. Currie, Jeffrey E. Kropf, Seung H. Lee, Jennifer R. Lo, Scott A. Mitchell, Aaron C. Schmitt, Sundaramoorthi Swaminathan, Jin-Ming Xiong, Jianjun Xu, Zhongdong Zhao
  • Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
    Patent number: 11384082
    Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula IA: are provided. Also provided are process for making the polymorphs and methods of use thereof.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: July 12, 2022
    Assignee: Kronos Bio, Inc.
    Inventors: Tim G. Elford, Peter Chee-Chu Fung, Paul Robert Hartmeier, Jesper Alexis Jernelius, Henry Morrison
  • Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors
    Patent number: 11339168
    Abstract: Solid forms of the compound, 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine, and solid forms of salts or co-crystals of Compound I, were prepared and characterized: Also provided are processes of making the solid forms and methods of use thereof.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: May 24, 2022
    Assignee: Kronos Bio, Inc.
    Inventors: Patricia Andres, Peter C. Fung, Pierre Giguere, Chiajen Lai, Craig Stewart, Jing Teng, Duong D. Tran, Iva Trantcheva, Brian Yarmuch
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY
    Publication number: 20220002305
    Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):
    Type: Application
    Filed: September 15, 2021
    Publication date: January 6, 2022
    Applicant: Kronos Bio, Inc.
    Inventors: Peter MIKOCHIK, Joseph VACCA, David FREEMAN, Andrew S. TASKER
  • Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity
    Patent number: 11155560
    Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: October 26, 2021
    Assignee: kronos bio, inc.
    Inventors: Peter Mikochik, Joseph Vacca, David Freeman, Andrew S. Tasker
  • Imidazopyridines Syk inhibitors
    Patent number: 10842803
    Abstract: Certain imidazopyridines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: November 24, 2020
    Assignee: KRONOS BIO, INC.
    Inventors: Peter A. Blomgren, Kevin S. Currie, Jeffrey E. Kropf, Seung H. Lee, Scott A. Mitchell, Aaron C. Schmitt, Jianjun Xu, Zhongdong Zhao
  • Crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Patent number: 10828299
    Abstract: The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: November 10, 2020
    Assignee: KRONOS BIO, INC.
    Inventors: Peter A. Blomgren, Kevin S. Currie, Jeffrey E. Kropf, Seung H. Lee, Jennifer R. Lo, Scott A. Mitchell, Aaron C. Schmitt, Sundaramoorthi Swaminathan, Jin-Ming Xiong, Jianjun Xu, Zhongdong Zhao