Abstract: The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
Type:
Application
Filed:
June 18, 2009
Publication date:
October 15, 2009
Applicants:
Translational Genomics Research Institute, Kronos Science Laboratory
Inventors:
Dietrich A. STEPHAN, Eric M. Reiman, Jennifer Webster, Christopher B. Heward, Pamela Heward, Andreas Papassotiropoulos
Abstract: The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
Type:
Application
Filed:
April 21, 2008
Publication date:
October 1, 2009
Applicants:
TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, KRONOS SCIENCE LABORATORY
Inventors:
Dietrich A. Stephan, Eric M. Reiman, Jennifer Webster, Christopher B. Heward, Pamela Heward, Andreas Papassotiropoulos