Abstract: A catheter securement device having a biocompatible, preferably anti-microbial, adhesively-backed main body, a mounting body affixed to the upper side of the main body, and a pair of retention strap members extending preferably substantially parallel to each other from the mounting body, the retention strap members joined to the mounting body along angled fold lines, such that the retention strap members overlap when folded along the fold lines. An adhesive layer is provided on the mounting body and the retention strap members which adheres to a catheter when the catheter is positioned on the mounting body and the retention strap members are folded across the catheter.