Patents Assigned to Kumamoto Technology and Industry Foundation
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Patent number: 10260130Abstract: Disclosed is a magnesium alloy material having excellent tensile strength and favorable ductility. Therefore, the magnesium alloy sheet material formed by rolling a magnesium alloy having a long period stacking order phase crystallized at the time of casting includes in a case where a sheet-thickness traverse section of an alloy structure is observed at a substantially right angle to the longitudinal direction by a scanning electron microscope, a structure mainly composed of the long period stacking order phase, in which, at least two or more ?Mg phases having thickness in the observed section of 0.5 ?m or less are laminated in a layered manner with the sheet-shape long period stacking order phase.Type: GrantFiled: March 13, 2015Date of Patent: April 16, 2019Assignees: National University Corporation Kumamoto University, Kumamoto Technology & Industry Foundation, Nissan Motor Co., LtdInventors: Yoshihito Kawamura, Masafumi Noda, Hiroshi Sakurai
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Patent number: 7803533Abstract: An object of the present invention is to provide a novel and clinically useful diagnostic agent for malignant melanoma. The present invention provides a diagnostic agent for malignant melanoma, which comprises an antibody against GPC3, or a probe or a primer capable of detecting GPC3 expression.Type: GrantFiled: October 28, 2004Date of Patent: September 28, 2010Assignee: Kumamoto Technology & Industry FoundationInventors: Yasuharu Nishimura, Tetsuya Nakatsura
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Patent number: 7667006Abstract: The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10?9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.Type: GrantFiled: March 9, 2004Date of Patent: February 23, 2010Assignee: Kumamoto Technology and Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara, Chiemi Minoda
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Publication number: 20090318579Abstract: A method for rapidly depolymerizing a polyester and an unsaturated polyester by irradiating the polyester with microwaves in the presence of an alkylene glycol in which a titanium oxide fine powder having a bulk density of not more than 0.3 g/cm3 has been dispersed. Another embodiment comprises irradiating a polyester or an unsaturated polyester with microwaves in the presence of a monohydric alcohol or polyhydric alcohol containing an alkali metal and/or an alkaline earth metal. As a result, raw materials of a polyester, an unsaturated polyester or a polyurethane, such as an alkylene glycol and an unsaturated dibasic acid, can be recovered efficiently.Type: ApplicationFiled: September 29, 2006Publication date: December 24, 2009Applicant: KUMAMOTO TECHNOLOGY AND INDUSTRY FOUNDATIONInventor: Kazutoshi Ikenaga
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Publication number: 20090074800Abstract: An object of the present invention to provide: a human pancreatic cancer antigen and/or a human colon cancer antigen that can be applied to the diagnosis and/or treatment of various types of cancers or tumors including pancreatic cancer and colon cancer as representative examples; a gene encoding the same; an anti-cancer vaccine using the same; or the like. The present invention provides a cancer antigen comprising a protein having the amino acid sequence shown in SEQ ID NO: 1; a peptide comprising a portion of said protein and having immune-stimulating activity; an anti-cancer vaccine comprising said peptide; a DNA having the nucleotide sequence shown in SEQ ID NO: 2, or its complementary sequence or a part or full length of these sequence; an anti-cancer vaccine comprising said DNA; and use thereof.Type: ApplicationFiled: June 11, 2008Publication date: March 19, 2009Applicant: Kumamoto Technology & Industry FoundationInventors: Tetsuya Nakatsura, Yasuharu Nishimura
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Publication number: 20090014897Abstract: A semiconductor chip (20) including a protruding electrode (bump) (23) in an external extraction electrode is mounted on a wiring board (10), and a semiconductor chip (30) is mounted on the semiconductor chip (20). Electrical connections between a wiring layer (12) of the wiring board (10) and the protruding electrode (23) of the semiconductor chip (20) and between the protruding electrodes of the semiconductor chips (20) and (30) are established by electrolytic plating. Stable connections between the wiring layer (12) and the protruding electrode (23) and between the protruding electrodes of the semiconductor chips (20) and (30) are established by plating films (24) and (33).Type: ApplicationFiled: July 17, 2008Publication date: January 15, 2009Applicant: Kumamoto Technology & Industry FoundationInventor: Yasuhide Ohno
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Publication number: 20080050365Abstract: The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.Type: ApplicationFiled: March 9, 2004Publication date: February 28, 2008Applicant: Kumamoto Technology and Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara, Chiemi Minoda
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Publication number: 20070218537Abstract: A process for treating ammonia containing wastewater includes bringing an ammonia-treating material and ammonia containing wastewater into contact with each other to remove ammonia in the wastewater continuously as nitrogen gas, the ammonia-treating material including a long carrier and complex bacterial sludge attached and immobilized on the biomass carrier, the carrier including a net, a nonwoven fabric or a woven fabric of fibers or filaments, the carrier being attached to a support, the complex bacterial sludge containing bacterial sludge including autotrophic anammox bacteria and bacterial sludge including autotrophic ammonia-oxidizing bacteria, the ammonia containing wastewater containing dissolved oxygen at a concentration of not less than 0.5 mg/l.Type: ApplicationFiled: March 30, 2005Publication date: September 20, 2007Applicant: Kumamoto Technology and Industry FoundationInventors: Kenji Furukawa, Hiroyuki Tokito
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Patent number: 7138509Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: GrantFiled: October 12, 2004Date of Patent: November 21, 2006Assignee: Kumamoto Technology & Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Publication number: 20060231927Abstract: A semiconductor chip (20) including a protruding electrode (bump) (23) in an external extraction electrode is mounted on a wiring board (10), and a semiconductor chip (30) is mounted on the semiconductor chip (20). Electrical connections between a wiring layer (12) of the wiring board (10) and the protruding electrode (23) of the semiconductor chip (20) and between the protruding electrodes of the semiconductor chips (20) and (30) are established by electrolytic plating. Stable connections between the wiring layer (12) and the protruding electrode (23) and between the protruding electrodes of the semiconductor chips (20) and (30) are established by plating films (24) and (33).Type: ApplicationFiled: May 14, 2004Publication date: October 19, 2006Applicant: KUMAMOTO TECHNOLOGY & INDUSTRY FOUNDATIONInventor: Yasuhide Ohno
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Publication number: 20060057695Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: ApplicationFiled: October 12, 2004Publication date: March 16, 2006Applicant: KUMAMOTO TECHNOLOGY & INDUSTRY FOUNDATIONInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Patent number: 6825020Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: GrantFiled: August 12, 2003Date of Patent: November 30, 2004Assignee: Kumamoto Technology & Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Publication number: 20040229309Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: ApplicationFiled: December 30, 2003Publication date: November 18, 2004Applicant: KUMAMOTO TECHNOLOGY & INDUSTRY FOUNDATIONInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Patent number: 6673913Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes the protein.Type: GrantFiled: December 5, 2001Date of Patent: January 6, 2004Assignee: Kumamoto Technology & Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara