Abstract: The disclosure provides a method of determining whether a subject is infected with a virus, comprising (1) testing whether a protein comprising an amino acid sequence of at least a part of the helicase domain of MDA5 protein and having a molecular weight of about 60 kDa is detected in a sample obtained from the subject; and (2) determining the subject is infected with the virus when the protein was detected. The disclosure also provides a monoclonal antibody capable of binding to the protein.

Abstract: Use of at least one microRNA comprising a nucleotide sequence set forth in any of SEQ ID NOS: 1 to 15 in a biological sample derived from a subject as a pancreatic cancer biomarker, wherein the pancreatic cancer biomarker is for determining whether the subject suffers from pancreatic cancer, for determining a pathological condition of the subject suffering or suffered from pancreatic cancer, or for identifying a test substance capable of treating pancreatic cancer.

Abstract: A sensor connector apparatus is disclosed to connected between an electroencephalographic spectrum analyzer and a sensor for use in the electroencephalographic spectrum analyzer. The sensor connector apparatus includes sensor connectors. Each of the sensor connectors includes: a connector to be connected to the electroencephalographic spectrum analyzer; a connector lead where the connector is connected to one end of the connector lead; and a conductive connector electrode that is connected to another end of the connector lead, and is connected to a sensor electrode of the sensor. The electroencephalographic spectrum analyzer is a bispectral index (BIS) processor, the sensor is a BIS Quatro sensor to be connected to the BIS processor, and the connector is connected to a sensor electrode of the BIS Quatro sensor.

Abstract: A method of treating Rett Syndrome (RTT) comprising administering ghrelin to a subject in need thereof.

Abstract: The disclosure provides a non-human transgenic animal having at least one CREBBP gene locus into which a mutation has been introduced, wherein the mutated CREBBP gene encodes a mutant CREBBP consisting of an amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO: 5. The disclosure also provides a method of producing the transgenic animal comprising introducing a mutation into at least one CREBBP gene locus of a non-human animal. The disclosure further provides use of the transgenic animal as a model of Rubinstein-Taybi syndrome or advanced sleep phase syndrome.

Abstract: The present invention provides an arteriovenous pressure measurement device which allows noninvasive and accurate measurement of arteriovenous pressure, and also provides an arteriovenous pressure measurement method using the measurement device. The noninvasive arteriovenous pressure measurement device comprises a probe (20) for radiating ultrasound toward a blood vessel in the skin, a pressing part (10) for pressing the skin in a state of being placed between the skin and the probe (20), and a pressure sensor (33) for detecting a pressing force applied to the skin at the pressing part (10), the pressing part (10) having water (36) permeable to the ultrasound and a balloon (31) accommodating the water (36), the flexible container (31) being made of a flexible material permeable to the ultrasound, and an outer surface of the balloon (31) presses the skin.

Abstract: Provided are a method for determining whether a subject suffering from a brain tumor is an eligible person for a tailor-made peptide vaccine composition including at least one peptide antigen, a kit used in the aforesaid determination method, and a method for treating a subject suffering from a brain tumor by administering a tailor-made peptide vaccine composition including at least one peptide antigen.

Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.

Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.

Abstract: A prophylactic and therapeutic agent for Rett Syndrome (RTT) is provided, a pharmaceutical composition comprising ghrelin and a pharmaceutically acceptable carrier and a prophylactic and therapeutic agent for RTT comprising a therapeutically effective amount of ghrelin. The side chain of serine at the 3rd position of ghrelin is modified with octanoic acid.

Abstract: In an adjuster for an airway securing device, a base member fixed to one of an upper jaw side attachment body and a lower jaw side attachment body is provided with a base member side half tube part and a slide member fixed to the other of the upper jaw side attachment body and the lower jaw side attachment body is provided with a slide member side half tube part. The base member side half tube part and the slide member side half tube part form a tube part in which an adjusting bolt is disposed on its inner peripheral side. A base member side flange part is formed at a base end of the base member side half tube part and a slide member side flange part shape is formed at a base end of the slide member side half tube part.

Abstract: A prophylactic and therapeutic agent for Rett Syndrome (RTT) is provided, a pharmaceutical composition comprising ghrelin and a pharmaceutically acceptable carrier and a prophylactic and therapeutic agent for RTT comprising a therapeutically effective amount of ghrelin. The side chain of serine at the 3rd position of ghrelin is modified with octanoic acid.

Abstract: The present invention provides an embedding resin composition for electron microscopy having satisfactory performance as an embedding medium, including embedding performance and sectioning quality, and exhibiting excellent antistatic performance; and a method for observing a sample with an electron microscope using the composition. The embedding resin composition for electron microscopy of the present invention having antistatic performance comprises an ionic liquid and an embedding medium comprising an epoxy-based resin, a methacrylate resin or an unsaturated polyester resin. Preferably, the ionic liquid comprising a quaternary ammonium compound based on the formula (I): and an anion selected from the group consisting of BF4?, PF6?, (CF3SO2)2N?, a halide ion, a conjugate base of carboxylic acid, a conjugate base of sulfonic acid and a conjugate base of an inorganic acid.

Abstract: Provided is a strain permitting genetic engineering of green sulfur bacteria that synthesize bacteriochlorophyll e; isolated green sulfur bacterium Chlorobaculum limnaeum strain RK-j-1 with accession number NITE BP-1202; isolated transformed Chlorobaculum limnaeum strain obtained by transformation of strain RK-j-1, preferably Chlorobaculum limnaeum dbchU strain with accession number NITE BP-1203 wherein bchU gene is disrupted; a production method of bacteriochlorophyll f containing a step of cultivating Chlorobaculum limnaeum strain dbchU; and bacteriochlorophyll f obtained by the aforementioned production method.

Abstract: The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample. Thereby, a method for detecting idiopathic interstitial pneumonia using a marker is provided.

Abstract: The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin.

Abstract: There is provided a method for producing a circular DNA which consists of a circular DNA formed from a single-molecule DNA and which does not comprise circular DNA formed from multiple-molecule DNA. According to the method of the present invention, a circular DNA molecule formed only from a single-molecule DNA can be reliably produced.

Abstract: The present invention provides a method for producing a circular DNA molecule having a specific structure that enables to distinguish circular DNA formed from a single DNA molecule (single-molecule circular DNA), from circular DNA formed from multiple DNA molecules (multiple-molecule circular DNA) and also from single-molecule circular DNA derived from the circular DNA formed from multiple DNA molecules. According to the present invention, only single-molecule circular DNA that is not derived from multiple-molecule circular DNA can be selected in the production of circular DNA.

Abstract: The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin.