Abstract: The present invention provides an improved surgical instrument for performing bone osteotomies with reduced heat generation.

Abstract: The present invention relates to a medicament comprising an arginine decomposing enzyme, and a citrulline converting enzyme useful for the treatment of cancer.

Abstract: The present invention relates to an apparatus and method for correcting misalignments of the paw in the foreleg of dogs and other animals. The realignment of the paw is intended to properly align the medial compartment of the elbow with the end of the humerus.

Abstract: The present invention provides an implant in a form of a truss, spanning the distance from diaphysis of the tibia to the tip of the calcaneus, thus fixing the ankle (hock) joint in extension. Gastrocnemius muscles are thus at close to their shortest length and their force capacity is greatly reduced, preventing the caudal luxation of the distal femur even if the cranial cruciate ligament is torn.

Abstract: The present invention relates to devices and methods useful in training dogs how to control the muscles involved in rotation of the tibia in order to reduce the risk of cranial cruciate rupture. The invention has further applications in training dogs to increase abduction of the hind limbs to avoid hip dysplasia, as well as abduction of the front limbs to avoid elbow dysplasia.

Abstract: The present invention provides an external brace, an orthosis, for treating disorders of joints in dogs and cats. The most relevant veterinary indication is a hock joint brace to treat cranial cruciate disease in dogs.

Abstract: The present invention provides a surgical instrument for performing closing wedge osteotomies by a single step procedure.

Abstract: The present invention relates to improved delivery of therapeutic biologics with the molecular weight in the range from 10 kDa to 70 kDa or therapeutic nuclear acids with the molecular weight in the range from 6 kDa to 10 kDa by the concurrent deployment of an insulin-glucose clamp.

Abstract: The present invention relates to the treatment of respiratory viral infections, including those caused by coronaviruses.

Abstract: The present application relates to a spherical bead (30) to be interposed between a locking bone screw head (2) and a receiving hole (34) in a bone plate (10) and to an implant construct comprising such a bead.

Abstract: The present invention relates to an improved preparation and delivery of asparaginase for use in medicine, e.g. in human and veterinary medicine.

Abstract: The invention relates to an external fixator device and a method of its use in treating bone fractures and in orthopedic interventions, such as corrective osteotomies.

Abstract: The present invention resolves the main problems of bone-sparing resurfacing surgery of the medial compartment of the knee in dogs and in people. With a hard, low abrasion, low friction coating of the implant (100), such as ADLC or pyrolytic carbon, it is possible to resurface only one side of the joint. In this case, the tibia plateau resurfacing with a concave recess on its femur-facing surface provides not only pain-free mobility but also the necessary stability of the joint with a deficient cruciate ligament. The planar osteotomy of the medial condyle, with or without resurfacing, can also be used to emulate TPLO procedure limited to the medial compartment of the stifle.

Abstract: The invention relates to an external fixator device and a method of its use in treating bone fractures and in orthopedic interventions, such as corrective osteotomies.

Abstract: The present invention relates to devices and methods useful in training dogs how to control the muscles involved in rotation of the tibia in order to reduce the risk of cranial cruciate rupture. The invention has further applications in training dogs to increase abduction of the hind limbs to avoid hip dysplasia, as well as abduction of the front limbs to avoid elbow dysplasia.

Abstract: A link (1) for connecting two loops of a flexible tension-carrying construct (2, 2a). It solves the problem of providing effective means to connect two anchor points (7, 7a), typically on bones articulating at a joint by the flexible tension-carrying construct.

Abstract: The present invention includes a device for engaging surgical tethers used in surgical repair, allowing for near full load application to the tether without failure at the site of restraint in the holding mechanism, with economical construction, compact size, and manageable complexity, without sharp edges that will cut the polymer fibers, and without requiring expensive polishing. The holding mechanisms comprise a tether, an orifice sheath, and a restraint element. The tether forms a bight projecting from the orifice sheath, the direction of projection being opposite to the direction of functional pull on the tether, where the bight is formed from a continuous tether or from coupled tether ends, and the restraint element is a fusiform structure positioned under the bight of the tether and over an orifice in the orifice sheath.

Abstract: The present invention provides a surgical treatment for a disordered knee in a dog, the disorder comprising a partially ruptured cranial cruciate ligament (CrCL), a fully ruptured CrCL, or a displaced patella. The methods of treatment include surgical transection of the tendon of the popliteal muscle, which reduces the in-toeing of the paw as it lands on the ground. In vitro experiments suggest that neutralization of this torque can reduce by several fold tensile forces in the CrCL or its replacement, as well as in its surrogate, a lateral suture placed extra-capsularly.

Abstract: The invention relates to a total prosthesis for the shoulder joint. It is of the socalled reverse type with a concave component in the humerus and a convex component on the scapula.

Abstract: Disclosed herein are distraction implants for treating, for example, spinal disorders. The implants can be comprised of a U-shaped elastic member, two bone anchor members and two tension members to couple the components together. Use of the tension members allows for transfer of distraction force without unintended forces in the perpendicular plane and parasitic moments. As there are several options for anchoring to bone, the present implants can be applied to all segments of the spine from the cervical spine to the lumbar regions. The implant can be temporary or permanent, covering indications from fracture treatment to management of chronic disc disorders, including disc protrusion. Use of the present implant and methods of use are also within the scope of the invention.