Patents Assigned to Kyowa Hakko Kabushiki Kaisha
  • Bioxanthracene derivatives
    Patent number: 5081264
    Abstract: A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.The compounds are capable of protecting the nerve cells and also antagonistic activity against N-methyl-D-aspartic acid receptors.They may be prepared by fermentation of a microorganism of the genus Verticillium or a mutant thereof.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: January 14, 1992
    Assignee: Kyowa Hakko Kabushiki Kaisha
    Inventors: Shinichiro Toki, Mika Nozawa, Mayumi Yoshida, Hiroshi Sano, Katsuhiko Ando, Isao Kawamoto, Yuzuru Matsuda, Junichi Ikeda, Kazuhiro Kubo