Patents Assigned to Kyowa Hakko Kogyo K.K.
  • Mitomycin compounds having useful anti-tumor activity
    Patent number: 4863935
    Abstract: Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.
    Type: Grant
    Filed: December 11, 1987
    Date of Patent: September 5, 1989
    Assignee: Kyowa Hakko Kogyo K.K.
    Inventors: Yasushi Shida, Tokuyuki Kuroda, Ikuo Matsukuma, Makoto Morimoto, Tadashi Ashizawa
  • Cardiotonic quinazoline derivatives
    Patent number: 4668683
    Abstract: Quinazoline derivatives and their pharmaceutically acceptable acid addition salts having the general formula ##STR1## wherein R.sup.1 and R.sup.2 each represents hydrogen or alkyl;R.sup.3 represents alkyl or substituted alkyl;R.sup.7 and R.sup.8 each represent alkoxy;Z is oxygen or sulfur;m is zero or 1;n is zero or an integer from 1 to 5,exhibit a cardiotonic activity with little tendency to cause tachycardia.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: May 26, 1987
    Assignee: Kyowa Hakko Kogyo K.K.
    Inventors: Haruki Takai, Yuji Nomoto, Tadashi Hirata, Tetsuji Ohno, Kazuhiro Kubo