Abstract: The present invention exhibits strong preventive effects and/or therapeutic effects with regard to inflammatory disorders and/or pain disorders by combining and administering glutathione trisulfide or a pharmaceutically-acceptable salt thereof and a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a method for separating a compound represented by Formula (1) or (2) [in the formula, P1 is a hydrogen atom or a protective group of a hydroxyl group, R1 is a linear or branched C1-6 alkyl group that may be substituted with a phenyl group, A is an alkenylene group, and R2 is a hydroxyl group, a C1-3 alkoxy group, a mono(C1-3 alkyl)amino group, or a di(C1-3 alkyl)amino group] from a geometrical isomer thereof, in which the geometrical isomer is a geometrical isomer in a double bond included in A, the method including processing a mixture containing the compound and the geometrical isomer thereof by a chromatographic method using an acidic functional group-modified silica gel as a stationary phase.

Abstract: A compound represented by Formula (1) below or a salt thereof.

Abstract: A compound represented by Formula (1) or (3). wherein R1 and R2 are each independently a hydrogen atom; a C1-6 alkyl group optionally having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11; or —(CH2CH2O)nR8; wherein R4 is a C1-6 alkyl group having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11, or —(CH2CH2O)nR8; wherein R5, R6, R7, R8, R9, R10 and R11 are each independently a hydrogen atom or a C1-3 alkyl group; and n is an integer of 2 to 5.

Abstract: Disclosed is a method for producing a trisulfide compound or a selenotrisulfide compound. This production method includes: a step for oxidizing a disulfide compound with an oxidizing agent to obtain a sulfoxide compound; and a step for reacting the sulfoxide compound that has been obtained with a source of sulfur or a source of selenium to obtain a trisulfide compound or a selenotrisulfide compound.

Abstract: A prostaglandin production method according to the present invention comprises reacting an unsaturated fatty acid with cyclooxygenase in the presence of a reducing agent. According to the present invention, it is possible to produce prostaglandins at a high yield.

Abstract: The present invention provides a method for producing a compound represented by Formula (1a), (1b), or (1c), comprising a step of reducing a compound represented by Formula (3) in the presence of a metal complex represented by Formula (5), an inorganic base, and a solvent under a hydrogen atmosphere to obtain a compound represented by Formula (4). In the formula, Ar1 is an aryl group, each Are is independently a phenyl group or the like, W is a biphenyl group or the like, Z is an ethylene group that is substituted with a phenyl group or the like, and L is a chlorine atom or if Z has a phenyl group or a C1-3 alkoxyphenyl group, L is one of carbon atoms constituting the phenyl group or the C1-3 alkoxyphenyl group.