Patents Assigned to Kythera Biopharmaceuticals, Inc.
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Publication number: 20150064137Abstract: Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.Type: ApplicationFiled: April 16, 2013Publication date: March 5, 2015Applicant: Kythera Biopharmaceuticals, Inc.Inventors: Serge Lichtsteiner, Nathaniel David
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Patent number: 8883770Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: GrantFiled: January 14, 2013Date of Patent: November 11, 2014Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Publication number: 20140155364Abstract: The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicant: Kythera Biopharmaceuticals, Inc.Inventors: Robert Emil Hodge, Jeffrey Douglas Webster
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Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
Patent number: 8653058Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.Type: GrantFiled: August 10, 2011Date of Patent: February 18, 2014Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty -
Publication number: 20140038932Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: ApplicationFiled: June 10, 2013Publication date: February 6, 2014Applicant: KYTHERA BIOPHARMACEUTICALS, INC.Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Publication number: 20130261317Abstract: This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation.Type: ApplicationFiled: September 19, 2011Publication date: October 3, 2013Applicant: KYTHERA BIOPHARMACEUTICALS, INC.Inventors: Robert M. Moriarty, Photon Rao
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Patent number: 8546367Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: GrantFiled: June 1, 2012Date of Patent: October 1, 2013Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Publication number: 20130190282Abstract: The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.Type: ApplicationFiled: January 3, 2013Publication date: July 25, 2013Applicant: KYTHERA BIOPHARMACEUTICALS, INC.Inventor: Kythera Biopharmaceuticals, Inc.
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Publication number: 20130190283Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: ApplicationFiled: January 14, 2013Publication date: July 25, 2013Applicant: KYTHERA BIOPHARMACEUTICAL, INC.Inventor: Kythera Biopharmaceutical, Inc.
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Patent number: 8461140Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: GrantFiled: June 1, 2012Date of Patent: June 11, 2013Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Publication number: 20130102580Abstract: Provided herein are polymorphic forms of deoxycholic acid (DCA), improved methods of synthesizing DCA and intermediates thereto, and compositions and fat removal methods employing the DCA as provided herein.Type: ApplicationFiled: September 20, 2012Publication date: April 25, 2013Applicant: Kythera Biopharmaceuticals, Inc.Inventor: Kythera Biopharmaceuticals, Inc.
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Patent number: 8367649Abstract: The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.Type: GrantFiled: December 12, 2011Date of Patent: February 5, 2013Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert Emil Hodge, Jeffrey Douglas Webster
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Patent number: 8367852Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.Type: GrantFiled: May 25, 2011Date of Patent: February 5, 2013Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
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Patent number: 8362285Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.Type: GrantFiled: January 20, 2011Date of Patent: January 29, 2013Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
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Patent number: 8242294Abstract: Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.Type: GrantFiled: August 13, 2009Date of Patent: August 14, 2012Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Patent number: 8101593Abstract: The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.Type: GrantFiled: March 2, 2010Date of Patent: January 24, 2012Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Robert Emil Hodge, Jeffrey Douglas Webster
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Patent number: 7994351Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.Type: GrantFiled: November 6, 2009Date of Patent: August 9, 2011Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
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Patent number: 7902387Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.Type: GrantFiled: May 16, 2008Date of Patent: March 8, 2011Assignee: Kythera Biopharmaceuticals, Inc.Inventors: Achampeta Rathan Prasad, Roy A. Swaringen, Jr., John Gregory Reid, Robert M. Moriarty, Akhila Kumar Sahoo
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Publication number: 20100179337Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.Type: ApplicationFiled: May 16, 2008Publication date: July 15, 2010Applicant: Kythera Biopharmaceuticals, Inc.Inventors: Achampeta Prasad, Roy Swaringen, John Reid, Robert Moriarty, Akhila Sahoo
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Publication number: 20090259166Abstract: Systems and methods of polymerizing compositions with a light source may be provided. A device may include a handheld light source, which may include an LED, which may provide light at limited wavelengths to polymerize a composition. The device may be used to photo-polymerize dermal fillers transdermally via ex vivo applications. Dermal fillers may be compositions including PEODA 3400 and eosin Y, which may be polymerizable when exposed to light.Type: ApplicationFiled: April 11, 2008Publication date: October 15, 2009Applicant: Kythera Biopharmaceuticals, Inc.Inventors: Robert K.G. Trow, Andrew S. Thomas, Nathaniel David