Patents Assigned to Kyushu University, National University Corporation
  • FREE RADICAL CONSUMPTION SPEED INFORMATION ACQUISITION METHOD AND NASH DETERMINATION METHOD
    Publication number: 20190133517
    Abstract: A method for obtaining an index for non-invasively identifying NASH is provided. A NASH determination method comprising a method for acquiring free radical consumption speed information by non-invasively detecting a redox reaction in a liver of a test animal in real time, comprises a step (1) of obtaining free radical concentration data by applying a magnetic resonance method to the liver as a measurement target after administering a probe into a body; a step (2) of obtaining imaging information by processing the obtained free radical concentration data; and a step (3) of obtaining a free radical consumption speed by kinetically measuring the imaging information over time, and comprises a step of determining whether or not the test animal has NASH, based on the free radical consumption speed information obtained through application to the test animal.
    Type: Application
    Filed: June 9, 2017
    Publication date: May 9, 2019
    Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Masaharu Murata, Fuminori Hyodo, Makoto Hashizume, Ryosuke Nakata, Tomohiko Akahoshi
  • Catechin function enhancement method
    Patent number: 10251408
    Abstract: The present invention provides a composition comprising a tea extract or a catechin and a citrus fruit extract or a flavanone or a glycoside thereof.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: April 9, 2019
    Assignee: Kyushu University, National University Corporation
    Inventor: Hirofumi Tachibana
  • COOLING DEVICE
    Publication number: 20190099169
    Abstract: A cooling device may be configured to cool a shape-memory alloy member. The cooling device may include: a cooling unit configured to cool the shape-memory alloy member or a part that is to make contact with the shape-memory alloy member; a refrigerant supply pipe including one end connected to a refrigerant supply source and other end connected to the cooling unit, the refrigerant supply pipe configured to supply a refrigerant supplied from the refrigerant supply source to the cooling unit; and a refrigerant discharge pipe including one end connected to the cooling unit, the refrigerant discharge pipe configured to discharge the refrigerant discharged from the cooling unit from other end of the refrigerant discharge pipe.
    Type: Application
    Filed: March 6, 2017
    Publication date: April 4, 2019
    Applicants: YOSHIMI INC., AKIYAMA MEDICAL CO., LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Yukiharu YOSHIMI, Hirohisa KAWAI, Tetsuo IKEDA
  • Hydrosilylation iron catalyst
    Patent number: 10239896
    Abstract: A hydrosilylation iron catalyst prepared from a two-electron ligand (L) and a mononuclear, binuclear, or trinuclear complex of iron indicated by formula (1), Fe having bonds with carbon atoms included in X and the total number of Fe-carbon bonds being 2-10. As a result of using iron, the hydrosilylation iron catalyst is advantageous from a cost perspective as well as being easily synthesized. Hydrosilylation reactions can be promoted under mild conditions by using this catalyst. Fe(X)a??(1) (in the formula, each X independently indicates a C2-30 ligand that may include an unsaturated group excluding carbonyl groups (CO groups) and cyclopentadienyl groups, however at least one X includes an unsaturated group, a indicates an integer of 2-4 per Fe atom.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: March 26, 2019
    Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Hideo Nagashima, Yusuke Sunada, Daisuke Noda, Hiroe Soejima, Koji Sakuta
  • Organic electro-luminescent element and bioinstrumentation device
    Patent number: 10228328
    Abstract: An organic EL element having a luminescence peak in a near-infrared range comprises a positive electrode, a negative electrode, and at least one organic layer including a luminescent layer located between the positive electrode and the negative electrode. The luminescent layer comprises a host material, a delayed fluorescent material and a luminescent material. The LUMO and HOMO energy levels of the delayed fluorescent material and the luminescent material, the absorption spectrum of the luminescent material, and the emission spectrum of the delayed fluorescent material satisfy predetermined relationships.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 12, 2019
    Assignees: Kyushu University, National University Corporation, HAMAMATSU PHOTONICS K.K.
    Inventors: Chihaya Adachi, Hajime Nakanotani, Takahiko Yamanaka, Shigeo Hara, Toru Hirohata
  • Organic light-emitting device
    Patent number: 10230064
    Abstract: An organic light-emitting device having a layer 10 containing a delayed blue fluorescent material, a layer 11 containing separately or together a green fluorescent material and a red fluorescent material, and a spacer layer 12 arranged between the layer 10 and the layer 11 can efficiently emit white color.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: March 12, 2019
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Hajime Nakanotani, Chihaya Adachi, Takahiro Higuchi
  • SYSTEM, DEVICE, AND METHOD FOR PRODUCING ION CONCENTRATION GRADIENT, AND TEMPERATURE-RESPONSIVE ELECTROLYTE MATERIAL
    Publication number: 20190070555
    Abstract: A system for producing an ion concentration gradient and a temperature-responsive electrolyte material which are utilizable, for example, for efficiently converting heat energy that has been discarded into reusable energy or for efficiently recovering an acid gas, such as carbon dioxide is provided. A temperature-responsive electrolyte is used to produce an ion concentration gradient by means of a temperature gradient. The temperature-responsive electrolyte is used in the state of an aqueous solution and also in the state of a solid phase.
    Type: Application
    Filed: October 16, 2018
    Publication date: March 7, 2019
    Applicant: Kyushu University, National University Corporation
    Inventors: Yu HOSHINO, Yoshiko MIURA, Mengchen YUE, Kazushi IMAMURA
  • SUTURE NEEDLE
    Publication number: 20190059882
    Abstract: A suture needle for endoscopic surgery, may include: a needle body; a suture thread; and a connector configured to connect the needle body and the suture thread, wherein the needle body mat be constituted of a shape memory alloy, may have an arc shape as its original shape, and may be configured to be restored to the arc shape at a predetermined temperature or higher, and the connector may be constituted of a material different from the shape memory alloy.
    Type: Application
    Filed: March 6, 2017
    Publication date: February 28, 2019
    Applicants: YOSHIMI INC., AKIYAMA MEDICAL CO., LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, SAKUMA SPECIAL STEEL CO., LTD.
    Inventors: Yukiharu YOSHIMI, Hirohisa KAWAI, Tetsuo IKEDA, Kazusi TAKAMATSU
  • DNA POLYMERASE VARIANT
    Publication number: 20190055527
    Abstract: The present invention relates to a fusion polypeptide containing, in a direction of from an N-terminal side to a C-terminal side, one or more peptides which bind to a PCNA, and a polypeptide having a DNA polymerase activity; a method for amplifying nucleic acids using the polypeptide; and a composition and a kit, containing the polypeptide. According to the present invention, it is made possible to amplify a long-strand DNA in a short time in amplifying nucleic acids in the presence of PCNA even with a Pol I-type DNA polymerase.
    Type: Application
    Filed: November 24, 2016
    Publication date: February 21, 2019
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, TAKARA BIO INC.
    Inventors: Yoshizumi ISHINO, Sonoko ISHINO, Takeshi YAMAGAMI, Takashi UEMORI, Nariaki TAKATSU
  • NOVEL DNA POLYMERASE
    Publication number: 20190032031
    Abstract: Provided are various novel DNA polymerases. Provided are: a DNA polymerase comprising: an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 12, which has a substitution of arginine at position 651 by an amino acid residue having a negatively charged side chain, preferably by asparatic acid or glutamic acid, more preferably by glutamic acid; and a DNA polymerase comprising an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 14, which has a substitution of proline at position 653 by an amino acid residue having a negatively charged side chain, preferably by asparatic acid or glutamic acid, more preferably by glutamic acid.
    Type: Application
    Filed: December 27, 2017
    Publication date: January 31, 2019
    Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Yoshizumi ISHINO, Takeshi YAMAGAMI, Hiroaki MATSUKAWA
  • PERCUTANEOUSLY ABSORBABLE COMPOSITION CONTROLLED IN RELEASE OF WATER-SOLUBLE EFFECTIVE INGREDIENT
    Publication number: 20190030166
    Abstract: The invention relates to a method for enhancing percutaneous absorbability of a water-soluble drug. The invention provides a complex formed by a water-soluble effective ingredient and a fat-soluble compound having an aldehyde group through an interaction which can be dissociated in water; a percutaneously absorbable composition comprising the complex, a percutaneous absorption controller and a fat-soluble medium; and a method for controlling release of the water-soluble effective ingredient from the complex in the skin.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 31, 2019
    Applicants: NISSAN CHEMICAL CORPORATION, KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Fumiyasu ONO, Masahiro GOTO, Osamu HIRATA, Takehisa IWAMA
  • OPTICAL MEMBER, LIGHT GUIDING MEMBER, AND METHOD FOR PRODUCING OPTICAL MEMBER
    Publication number: 20190011624
    Abstract: The purpose of the present invention is to provide an optical member and the like which enable suppression of diffusion of stray light due to a pigment even when the optical member and the like are used adjacent to a light guiding part through which incident light is transmitted. The optical member is configured to be used adjacent to the light guiding part through which the incident light is transmitted and to attenuate the incident light. The optical member has a dispersed carbon particle part that is formed as a result of dispersion of carbon particles in a particular region in a silicone resin. The carbon particles are stray light diffusion suppressing particles for suppressing the intensity of light being incident onto the carbon particles and diffused.
    Type: Application
    Filed: April 22, 2016
    Publication date: January 10, 2019
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, USHIO DENKI KABUSHIKI KAISHA
    Inventors: Yuji OKI, Kinichi MORITA
  • Agent for introducing protecting group for hydroxy group and/or mercapto group
    Patent number: 10160694
    Abstract: A novel agent for introducing a protecting group for a hydroxy group and/or a mercapto group that can be introduced and removed under mild conditions is provided. The agent for introducing a protecting group for a hydroxy group and/or mercapto group of a substrate compound having the hydroxy group and/or mercapto group is represented by the following formula (I), wherein A represents a ring structure having 1 to 5 rings in which two carbon atoms of an adjacent benzene ring are included, the ring structure comprises a substituted or unsubstituted five-membered ring or six-membered ring and optionally include a heterocycle; each of R1, R2, R3, and R4 is independently a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms; and X is a halogen atom or OSO2R5 (R5=an aryl group or an alkyl group).
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: December 25, 2018
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventor: Kohei Torikai
  • DNA POLYMERASE VARIANT
    Publication number: 20180346889
    Abstract: The present invention relates to a Thermus aquaticus (Taq) polymerase having a strand displacement activity in which an amino acid residue in a template DNA binding site of the DNA polymerase is substituted with an amino acid to increase a total charge in the site, a nucleic acid encoding the polymerase, a vector containing the nucleic acid, a transformant containing the vector containing the nucleic acid or the nucleic acid, a method for producing the polymerase, a method for amplifying nucleic acids utilizing the polymerase, and a kit containing the polymerase. According to the present invention, a DNA polymerase having a high thermostability, capable of efficiently replicating a long-strand of a template DNA, and having a strong strand displacement activity is provided.
    Type: Application
    Filed: November 24, 2016
    Publication date: December 6, 2018
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, TAKARA BIO INC.
    Inventors: Yoshizumi ISHINO, Sonoko ISHINO, Takeshi YAMAGAMI, Takashi UEMORI, Nariaki TAKATSU
  • LASER ANNEALING DEVICE
    Publication number: 20180350622
    Abstract: A laser annealing device includes: a CW laser device configured to emit continuous wave laser light caused by continuous oscillation to preheat the amorphous silicon; a pulse laser device configured to emit the pulse laser light toward the preheated amorphous silicon; an optical system configured to guide the continuous wave laser light and the pulse laser light to the amorphous silicon; and a control unit configured to control an irradiation energy density of the continuous wave laser light so as to preheat the amorphous silicon to have a predetermined target temperature less than a melting point thereof, and configured to control at least one of a fluence and a number of pulses of the pulse laser light so as to crystallize the preheated amorphous silicon.
    Type: Application
    Filed: August 6, 2018
    Publication date: December 6, 2018
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, GIGAPHOTON INC.
    Inventors: Hiroshi IKENOUE, Tomoyuki OHKUBO, Osamu WAKABAYASHI
  • BIOMARKER FOR DIAGNOSING DEPRESSION AND USE OF SAID BIOMARKER
    Publication number: 20180348195
    Abstract: An objective biomarker is capable of evaluating the severity of depression and is clinically useful. The biomarker is used for evaluating the severity of depression, and includes at least one compound selected from the group made of 4-aminobutyric acid (? (gamma)-aminobutyric acid: GABA), arginine, argininosuccinate, isoleucine, indole carboxaldehyde, potassium indoleacetate, carnitine, acetylcarnitine, ornithine, xanthurenate, kynurenate, kynurenine, citrate, creatine, creatinine, glutamine, dimethylglycine, serotonin, taurine, trimethyloxamine (TMAO), tryptophan, norvaline, 3-hydroxybutyrate, phenylalanine, proline, betaine, and lysine.
    Type: Application
    Filed: October 31, 2016
    Publication date: December 6, 2018
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY
    Inventors: Takahiro KATO, Daiki SETOYAMA, Dongchon KANG, Shigenobu KANBA, Ryota HASHIMOTO, Hiroshi KUNUGI, Kotaro HATTORI
  • LASER DOPING DEVICE AND SEMICONDUCTOR DEVICE MANUFACTURING METHOD
    Publication number: 20180342397
    Abstract: A laser doping device includes: a solution supply system configured to supply a solution containing dopant to a doping region; a pulse laser system configured to output pulse laser light including a plurality of pulses, the pulse laser light transmitting through the solution; a first control unit configured to control a number of pulses of the pulse laser light for allowing the doping region to be irradiated, and to control a fluence of the pulse laser light in the doping region; and a second control unit configured to control a flow velocity of the solution so as to move bubbles, from the doping region, occurring in the solution every time of irradiation with the pulse.
    Type: Application
    Filed: August 6, 2018
    Publication date: November 29, 2018
    Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, GIGAPHOTON INC.
    Inventors: Hiroshi IKENOUE, Akira SUWA, Osamu WAKABAYASHI
  • System, device and method for generating ion concentration gradient, and temperature-responsive electrolyte material
    Patent number: 10137409
    Abstract: A system for producing an ion concentration gradient and a temperature-responsive electrolyte material which are utilizable, for example, for efficiently converting heat energy that has been discarded into reusable energy or for efficiently recovering an acid gas, such as carbon dioxide is provided. A temperature-responsive electrolyte is used to produce an ion concentration gradient by means of a temperature gradient. The temperature-responsive electrolyte is used in the state of an aqueous solution and also in the state of a solid phase.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: November 27, 2018
    Assignee: Kyushu University, National University Corporation
    Inventors: Yu Hoshino, Yoshiko Miura, Kazushi Imamura, Ryohei Ohashi
  • MANIPULATOR
    Publication number: 20180333164
    Abstract: A manipulator includes a flexible actuating body, that includes a rectangular horizontal plate spring, a curved vertical plate spring which stands upright having a plate surface perpendicular to a plate surface of the horizontal plate spring, of which a base end is connected to one end of the horizontal plate spring in a longitudinal direction, which protrudes to one side in a width direction of the horizontal plate spring, which extends along the longitudinal direction of the horizontal plate spring, and of which a tip end in the extending direction is a portion bent in a direction opposite to the protruding direction, a shaft body which is connected to a tip end of the bent portion, and is rotatably supported at a center perpendicular to the plate surface of the horizontal plate spring, and an actuator protruding in a radius direction from an outer circumference of the shaft body.
    Type: Application
    Filed: September 30, 2016
    Publication date: November 22, 2018
    Applicant: Kyushu University, National University Corporation
    Inventors: Jumpei ARATA, Makoto HASHIZUME, Susumu OGURI
  • METHOD OF PRODUCING POLYMER-IMPREGNATED BASE RESIN
    Publication number: 20180327560
    Abstract: Provided is a method of producing a polymer-impregnated base resin which is excellent in providing low adsorption of proteins and blood cells such as platelets. The method of producing a polymer-impregnated base resin includes impregnating a base resin with a polymer solution that includes a solvent able to swell the base resin.
    Type: Application
    Filed: April 16, 2018
    Publication date: November 15, 2018
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Yasuhisa MINAGAWA, Keiji TANAKA, Hisao MATSUNO, Toyoaki HIRATA