Abstract: The present invention provides a compound capable of being used as an active ingredient of an anti-cancer agent. To provide an anti-cancer agent with few side effects, an object of the present invention is to provide a compound capable of selectively inhibiting the target, i.e., DOCK1, or a salt thereof. The pyridinone compound of the present invention is represented by Formula (1): wherein R1 and R2 are the same or different, and each represents C1-6 alkyl; and R3 is a group represented by, for example, Formula (3) below wherein R5 in the group represented by Formula (3) is hydrogen.

Abstract: A medical use honeycomb structure having a plurality of through-holes extending in one direction, wherein an outer peripheral section of the medical use honeycomb structure has a through-hole groove formed by incomplete side walls of the through-hole, and a through-hole inlet adjacent to the through-hole groove.

Abstract: Provided is a surface protection composition excellent in anticorrosion property for preventing metal corrosion as well as excellent in uniform applicability and heat resistance, and a terminal-fitted electric wire treated with the composition. The surface protection composition contains a phosphorus compound (a) represented by the general formula (1) in an amount of 0.1 to 10 mass % in terms of phosphorus element with respect to the total amount of the composition, at least one selected from the group consisting of a phosphorus compound (b1) represented by the general formula (2) and a carboxylic acid compound (b2) represented by the general formula (3) in an amount of 5.0 to 60 mass % with respect to the total amount of the composition, a metal-containing compound (c) in an amount of 0.1 to 10 mass % in terms of metal element with respect to the total amount of the composition, and a lubricant base oil (d).

Abstract: [Problem] To provide a power feed system that supplies electric power via electromagnetic waves to an implant embedded in a deep part of a living body, using a sandwiching method in which a potential difference is generated using a pair of electrodes, by disposing an implant electronic device between a power transmission side electrode and a power reception side electrode. [Solution] It is provided with: a pair of electrodes (a first surface electrode 3 and a second surface electrode 4) stuck onto a surface of a living body 6; an implant electronic device 2 that includes a first body internal electrode 30 and a second body internal electrode 40 and in which the first body internal electrode 30 and the second body internal electrode 40 are fixed to respective positions having different potential differences in the living body 6; and a high frequency AC power source 5 that applies a high frequency alternating voltage to the first surface electrode 3 and the second surface electrode 4.

Abstract: Provided are: a dicyano N-heterocyclic compound represented by formula (I) (in the formula, R3 represents an electron-donating group, and n represents the number of repetitions of the content in brackets and is 0 or 1), the compound having exceptional heat resistance and light emission characteristics; a light-emitting material; and a light-emitting element in which the same is used.

Abstract: An optical device (10) includes a first substrate (11) and a second substrate (12) facing each other, a liquid crystal component (13) between the first substrate (11) and the second substrate (12), a first electrode (18) and a second electrode (19) located on the first substrate (11) on the second substrate (12) side, and a first alignment layer (14) that is located on the first substrate (11) on the second substrate (12) side and controls the alignment state of liquid crystal molecules in the liquid crystal component (13), wherein an interface between the liquid crystal component (13) and the first alignment layer (14) forms a non-glide weak anchoring interface (17).

Abstract: It is desired to develop a method of producing hydrogen peroxide, which is capable of producing hydrogen peroxide with high production efficiency. According to the present invention, provided is a palladium-containing composition comprising palladium particles and a coating agent that coats the surface of the palladium particles, wherein a compound having an O?X structure (wherein X represents any of a phosphorus atom, a sulfur atom, and a carbon atom) is comprised as the coating agent.

Abstract: An immunoregulatory agent containing a regulatory agent that regulates Dedicator of cytokinesis 2 (DOCK2)-mediated Rac activation as an active ingredient is provided.

Abstract: A microplate reader includes a plurality of sets of: a light emitting portion disposed on one side of a microplate and corresponding to one well of the microplate; a light receiving portion disposed on an opposite side to the light emitting portion across the microplate and corresponding to one well of the microplate; and a light receiving light guide path disposed between the light receiving portion and the microplate and guiding light emitted from the light emitting portion and passing through a sample contained in the well to the light receiving portion. The microplate reader further includes a light guiding section configured to enclose a plurality of the light receiving light guide paths by an enclosure member made of a pigment-containing resin containing a pigment having a light-absorbing property. Light emitted from one light emitting portion passing through one light receiving light guide path and reaching one light receiving portion.

Abstract: A medical use honeycomb structure having a plurality of through-holes extending in one direction, wherein an outer peripheral section of the medical use honeycomb structure has a through-hole groove formed by incomplete side walls of the through-hole, and a through-hole inlet adjacent to the through-hole groove.

Abstract: A method for producing a microbial oil includes steps of: genetically modifying a labyrinthulid by disrupting and/or silencing a gene, or by transforming another gene in addition to the disruption and/or gene silencing of the gene, and culturing the labyrinthulid, such that a fatty acid composition accumulated in the labyrinthulid comprises an increased EPA content; and collecting the microbial oil having the increased EPA content from the labyrinthulid. The labyrinthulid before the modification is selected from (A) a labyrinthulid belonging to the genus Parietichytrium or genus Schizochytrium and having very weak or no activity of producing PUFAs via a PUFA-PKS pathway; and (B) a labyrinthulid belonging to the genus Thraustochytrium in which a host PUFA-PKS gene is disrupted or silenced to a very weak level. The increased EPA content is preferably not less than 11.5% of a total fatty acid composition.

Abstract: A method that can plate a predetermined position on various plating targets without implementing a pretreatment thereon is provided. A plating method is performed on a plating target using a plating solution, and the plating method includes at least a bubble ejection step of ejecting a bubble generated by a bubble ejection member to a plating solution. The bubble ejection member includes an electrode formed of a conductive material and an insulating material covering at least a part of the electrode, at least a part of the insulating material forms a bubble ejection port, and an air gap surrounded by the insulating material is formed between at least a part of the electrode and the bubble ejection port.

Abstract: A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path.

Abstract: Provided is a compound that is usable as an active ingredient of an anticancer agent. Preferably provided is a compound that has DOCK1-inhibiting activity and exerts an anticancer effect based on the activity.

Abstract: An atopic dermatitis model non-human animal, containing a gene mutation in which a complex containing dedicator of cytokinesis 8 (DOCK8) protein, mammalian STE20-like kinase 1 (MST1) protein, and endothelial PAS domain protein 1 (EPAS1) protein is not formed in CD4+ T cells.

Abstract: A semiconductor substrate contains a clathrate compound of the following General Formula (I). The semiconductor substrate includes a variable-composition layer which includes a pn junction and where composition of the clathrate compound varies along a thickness direction. A rate of change in y in the thickness direction of at least a portion of the variable-composition layer is 1×10?4/?m or more. AxByC46-y ??(I) In General Formula (I), A represents at least one element selected from the group consisting of Ba, Na, Sr, and K, B represents at least one element selected from the group consisting of Au, Ag, Cu, Ni, and Al, and C represents at least one element selected from the group consisting of Si, Ge, and Sn, x is 7 to 9, and y is 3.5 to 6 or 11 to 17.

Abstract: Provided are a surface protection composition which has excellent anticorrosion performance to prevent the metal corrosion, and also has excellent coating properties and heat resistance with suppressing cracks from being occurred even in a cold environment and maintaining anticorrosion performance, and a terminal-fitted electric wire using these. The present protection composition contains: (a) a phosphorus compound represented by the following general formula (1) in an amount of 0.1 to 10 mass % in terms of phosphorus element with respect to the total amount of the composition; (b) a metal-containing compound in an amount of 0.1 to 10 mass % in terms of the metal element with respect to the total amount of the composition or an amine compound in an amount of 0.1 to 5.0 mass % in terms of nitrogen element with respect to the total amount of the composition; (c) a (meth) acrylate having two or more carbon-carbon double bonds and hydrocarbon chains having four or more carbon atoms in an amount of 1.

Abstract: A blood pressure controlling apparatus includes an acquiring part configured to acquire biological information indicating blood pressure of a subject, a producing part configured to produce a frequency modulated pulse train on the basis of the biological information, and a supplying part configured to supply an electrical current on the basis of the frequency modulated pulse train, to an electrode attached on the subject. The electrical current stimulates baroreceptor afferent nerves of the subject.

Abstract: A microbial oil is obtained from Labyrinthulomycetes in which a gene for fatty acid biosynthesis has been disrupted or an expression of the gene has been inhibited to highly accumulate the fatty acid. The microbial oil typically contains: (a) 1.5% or more of arachidonic acid (AA) based on a total amount of fatty acid; (b) 0.2% or more of dihomo-?-linolenic acid (DGLA) based on the total amount of fatty acid; (c) 0.04% or more of eicosatetraenoic acid (ETA) based on the total amount of fatty acid; (d) 3.8% or more of eicosapentaenoic acid (EPA) based on the total amount of fatty acid; (e) 13.7% or less of n-6 docosapentaenoic acid (n-6DPA) based on the total amount of fatty acid; and (f) 43.9% or less of docosahexaenoic acid (DHA) based on the total amount of fatty acid.

Abstract: A surface protection composition forms a uniform film, and a terminal fitted electric wire coated with the composition, the composition containing (a) a phosphorus compound represented by the formula (1) in an amount of 0.1 to 10 mass % in terms of phosphorus element, (b) a metal-containing compound in an amount of 0.1 to 10 mass % in terms of metal element or an amine compound in an amount of 0.1 to 5.0 mass % in terms of nitrogen element, (c) a (meth)acrylate compatible with a solvent with a solubility parameter of 8.2 or lower and has a hydrocarbon chain with 4 or higher carbon atoms in an amount of 1.0 to 70 mass %, and (d) at least one of a photopolymerization initiator and a thermal polymerization initiator in an amount of 0.1 to 10 mass %, with respect to the total amount of the composition.