Patents Assigned to L.E.A.F. Holdings Group LLC
  • Alpha polyglutamated pemetrexed and uses thereof
    Patent number: 11779584
    Abstract: The disclosure relates generally to alpha polyglutamated pemetrexed, formulations containing liposomes filled with alpha polyglutamated pemetrexed, methods of making the alpha polyglutamated pemetrexed and liposome containing formulations, and methods of using polyglutamated alpha polyglutamated pemetrexed and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: October 10, 2023
    Assignee: L.E.A.F. HOLDINGS GROUP LLC
    Inventors: Clet Niyikiza, Victor Mandla Moyo
  • Gamma polyglutamated lometrexol and uses thereof
    Patent number: 11771700
    Abstract: The disclosure relates generally to gamma polyglutamated lometrexol compositions, including delivery vehicles such as liposomes containing the gamma polyglutamated lometrexol, and methods of making and using the gamma polyglutamated lometrexol compositions to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., inflammation and autoimmune diseases such as rheumatoid arthritis).
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: October 3, 2023
    Assignee: L.E.A.F. HOLDINGS GROUP LLC
    Inventors: Clet Niyikiza, Victor Mandla Moyo
  • Alpha polyglutamated pralatrexate and uses thereof
    Patent number: 11730738
    Abstract: The disclosure relates generally to alpha polyglutamated pralatrexate, formulations containing liposomes filled with alpha polyglutamated pralatrexate, methods of making the alpha polyglutamated pralatrexate and liposome containing formulations, and methods of using polyglutamated alpha polyglutamated pralatrexate and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: August 22, 2023
    Assignee: L.E.A.F. HOLDINGS GROUP LLC
    Inventors: Clet Niyikiza, Victor Mandla Moyo
  • Polyglutamated antifolates and uses thereof
    Patent number: 11534498
    Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with the polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using the polyglutamated antifolates and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Grant
    Filed: August 12, 2017
    Date of Patent: December 27, 2022
    Assignee: L.E.A.F. HOLDINGS GROUP LLC
    Inventors: Clet Niyikiza, Victor Mandla Moyo
  • Alpha polyglutamated antifolates and uses thereof
    Patent number: 11344628
    Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Grant
    Filed: August 12, 2017
    Date of Patent: May 31, 2022
    Assignee: L.E.A.F. HOLDINGS GROUP LLC
    Inventors: Clet Niyikiza, Victor Mandla Moyo
  • Targeted liposomal gemcitabine compositions and methods thereof
    Patent number: 10940112
    Abstract: This disclosure relates to a targeted PEGylated liposomal gemcitabine (PLG) composition comprising a PEGylated liposome encapsulating one or more agents comprising gemcitabine and a targeting moiety; pharmaceutical composition and methods comprising PLG or producing PLG; and manufacturing equipment for performing the methods.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: March 9, 2021
    Assignee: L.E.A.F. Holdings Group LLC
    Inventors: Clet Niyikiza, Victor Moyo, Zhenghong Xu, Kaniz Khalifa