Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a plurality of absorbable filaments arranged in a support structure and configured degrade within a defined time period and a membrane arranged about the plurality of absorbable filaments and configured to contain fragments of the plurality of absorbable filaments in response to a fracture or degradation of a filament.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: Provided is an antibody targeting CLDN18.2. The antibody targeting CLDN118.2 comprises VL and/or VH; the VL comprises the following CDR sequences: a VL CDR1 amino acid sequence as shown in SEQ ID NO: 11 or SEQ ID NO: 12; a VL CDR2 amino acid sequence as shown in SEQ ID NO: 13; and a VL CDR3 amino acid sequence as shown in SEQ ID NO: 14; and the VH comprises the following CDR sequences; a VH CDR1 amino acid sequence as shown in SEQ ID NO: 15; a VH CDR2 amino acid sequence as shown in SEQ ID NO: 16; and a VH CDR3 amino acid sequence as shown in SEQ ID NO: 17. Further disclosed are a bispecific antibody targeting CLDN18.2, a conjugates of the antibody, a CAR molecule targeting CLDN18.2 and a cell comprising same, and applications thereof.

Abstract: A method and apparatus for producing methanol from a synthesis gas is provided. The method includes (i) producing, in a partial oxidation chamber, the synthesis gas having a stoichiometric number of less than 1.8 by performing a partial oxidation process with a hydrocarbon stream and an oxygen stream, (ii) passing, in a water-gas shift reactor, the synthesis gas over a water-gas shift catalyst to convert at least a portion of carbon monoxide and water into hydrogen and carbon dioxide, (iii) producing a dry, shifted synthesis gas by separating liquid condensate from shifted synthesis gas, (iv) combining, in a recycle compressor, the dry, shifted synthesis gas with a recycle synthesis gas comprised of unreacted synthesis gas and a hydrogen rich product to form a mixed synthesis gas stream, and (v) converting, in a cooled methanol synthesis reactor, at least a portion of the mixed synthesis gas stream into methanol.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: An automatic liquid density measurement device includes a receptacle configured to contain the liquid, a float configured to be submerged in the liquid when it is contained in the receptacle, and an electronic system. The electronic system includes a first electromagnetic sensor configured to make a reference measurement relative to the electrical properties of the liquid, a second electromagnetic sensor configured to make a measurement of the volume of the liquid displaced when the float is submerged in the liquid, and an electronic circuit coupled with said first and second electromagnetic sensors to determine the density of the liquid based on the measurement of the physical properties of the liquid and the measurement of the volume of the liquid displaced.

Abstract: The invention relates to the uses of a new characterized TET protein showed restricted to N-terminus glycine residues exopeptidase. The invention also relates to a method comprising said use of said new characterized TET protein as a N-terminus glycine residues specific exopeptidase. The invention further relates to a support wherein it is immobilized on said new characterized TET protein as a N-terminus glycine residues specific exopeptidase.

Abstract: An implantable medical device is disclosed, in which the implantable medical device includes a fluid shunt extending through a wall separating a first cavity and a second cavity within the heart. The fluid shunt includes a first portion adapted to extend into the first cavity within the heart, a second portion adapted to extend into the second cavity within the heart, and an intermediate portion interconnecting the first and second portions. The fluid shunt having a lumen extending between the first and second portions that is adapted to fluidly couple the first and second cavities within the heart.

Abstract: A capacitive device including a metallic layer; a network of nanotube or nanowire bundles that extend from a face of the metallic layer; a capacitive stack covering the metallic layer and the nanotube bundles in a conforming manner, the stack including an upper conducting layer and an insulating layer, the device including a capacitive zone and a lower contact zone, the capacitive zone being a zone wherein the upper conducting layer encapsulates the nanotube bundles and the insulating layer, while the lower contact zone is a zone wherein the capacitive stack leaves the free ends exposed, and the insulating layer encapsulates the upper conducting layer.

Abstract: A reflector device reflects luminous radiation of wavelength ?. The device is provided with a supporting base whereon are assembled a partially transparent mirror having a partially reflective front face and luminous radiation scattering and/or absorption structure to scatter and/or absorb luminous radiation liable to be transmitted by a rear face, opposite the front face.

Abstract: A liquefaction apparatus that automatically adjusts the load on the liquefaction apparatus correspondingly with an upper limit value of contracted power in different time slots, and which is capable of maximizing the amount of liquefied product produced and of achieving optimum operating efficiency is provided.

Abstract: A method for producing power and argon is provided by providing a residual gas stream, purifying the residual gas stream in a front-end purification unit to remove carbon dioxide, thereby forming a purified residual gas stream, and introducing the purified residual gas stream to a cold box, wherein the purified residual gas stream is cooled and expanded within the cold box to produce power and then fed to a distillation column system for separation therein, thereby forming an argon-enriched stream and optionally a nitrogen-enriched stream and/or an oxygen-enriched stream, wherein the residual gas stream is sourced from a retentate stream of a cold membrane having oxygen, nitrogen, carbon dioxide, and argon.

Abstract: An image sensor provided with a pixel including a photosensitive region formed in a semiconductor substrate and surrounded by a peripheral isolation trench; a sense node formed on a charge collecting region; a charge transfer gate around the sense node; a well; the pixel being provided with a so-called “detection acceleration” transistor configured to, during a so-called “charge overflow detection” operation, be switched on so as to weaken a potential barrier generated by the transfer gate and thus to favour an overflow of photogenerated charges to the sense node of the photosensitive region and to accelerate detection of this overflow.

Abstract: A hollow fiber membrane bundle useful for manufacturing a wide variety of hollow fiber membrane modules having different flow configurations includes hollow fiber membranes arranged around a porous support tube, a cured resin tubesheet formed at first end of the bundle, and either a cured resin nub or a cured resin tubesheet formed at a second end of the bundle. The bore(s) of the hollow fiber membranes are open at a face of the tubesheet adjacent the first end of the bundle. The tubesheet has an annular structure that encapsulates the hollow fiber membranes and the porous support tube at the first end of the bundle but which does not completely block a bore of the porous support tube, wherein the collection tube has a plurality of orifices formed therein at least at positions adjacent the nub.

Abstract: A liquefaction system comprises: a temperature setting unit for setting an inlet gas temperature on entry to a cold turbine; a control valve for controlling an amount of gas fed to the cold turbine, correspondingly with an inlet gas temperature measured by the temperature measuring unit; and a control unit which compares the inlet gas temperature measured by the temperature measuring unit with a warning temperature set value plus a margin, and sets a first operating state when the inlet gas temperature is equal to or less than the warning temperature set value plus the margin and also sets an emergency stoppage temperature set value at the warning temperature set value plus the margin, and sets a second operating state when the inlet gas temperature is greater than the warning temperature set value plus the margin, the control unit performing control in response to the second operating state to make a degree of opening of the control valve greater than a degree of opening during the first operating state in o

Abstract: A method may form an electroconductive and hydrophobic microporous layer (MPL) at an active layer surface configured for an electrochemical converter, including: (a) providing a non-aqueous dispersion, called “ink”, including a carbon-based particulate material and an organic solvent; (b) forming an ink deposit at the active layer surface; and (c) evaporating the solvent(s) to form a microporous layer, simultaneously and/or subsequently to the forming (b). The ink may include poly(vinylidene fluoride-co-hexafluoropropene), dissolved in the organic solvent. Ink may prepare such a microporous layer, and a multilayer structure including an active layer supported by a solid electrolyte membrane and contacting, at its face on the opposite side the solid membrane, with a microporous layer obtained by the such a method. A membrane-electrode assembly may include such a multilayer structure. Such an MEA may be used in an individual cell of an electrochemical converter, in particular in a PEMFC.

Abstract: A system and method for controlling operating modes of a system, each operating mode being implemented by an execution of one or more software components. This control system includes software components called elementary components, each elementary component having at least one input able to receive input data and/or at least one output able to transmit output data; and at least one software meta-component including one or more internal wiring diagrams, each internal wiring diagram defining interconnections between inputs and outputs of elementary components and/or meta-components, a transition logic between states defining a current state of said system and a sequence between states at least some of the states corresponding to an implementation of an internal wiring diagram, a mechanism for controlling the internal configurations, and a programming interface providing services/functions implementing at least one internal wiring scheme.

Abstract: A hollow fiber membrane bundle useful for manufacturing a wide variety of hollow fiber membrane modules having different flow configurations includes hollow fiber membranes arranged around a porous support tube, a cured resin tubesheet formed at first end of the bundle, and either a cured resin nub or a cured resin tubesheet formed at a second end of the bundle. The bore(s) of the hollow fiber membranes are open at a face of the tubesheet adjacent the first end of the bundle. The tubesheet has an annular structure that encapsulates the hollow fiber membranes and the porous support tube at the first end of the bundle but which does not completely block a bore of the porous support tube, wherein the collection tube has a plurality of orifices formed therein at least at positions adjacent the nub.