Abstract: The present invention generally relates to a skin graft preparation device, or mesher. This device is designed to incise and "mesh" a piece of skin, usually prior to grafting to allow it to expand and cover an area larger than its donor site area. More specifically, the invention relates to an adjustable mesher device wherein the mesher has an adjustable meshing drum (roller) or drums useful for the meshing of the entire range of meshing ratios, thus eliminating the need to keep various meshing devices. Another embodiment of the mesher has two consecutive meshing drums. A further embodiment of the mesher has a rotatable common holder allowing selection from a number of meshing drums. These meshers can mesh skin in both powered and manual modes of operation and may be used with most existing graft carriers or may be used without any carrier. The present invention further relates to a system for using the mesher.