Abstract: The present invention relates to M. tuberculosis proteins and peptides, and subsequences, portions or modifications thereof and methods and compounds comprising the same for eliciting, stimulating, inducing, promoting, increasing, or enhancing an anti-M. tuberculosis immune response in a subject.
Type:
Grant
Filed:
October 1, 2012
Date of Patent:
July 7, 2020
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Inventors:
Alessandro Sette, Cecilia Arlehamm, Bjoern Peters, Howard Grey, John Sidney
Abstract: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.
Type:
Application
Filed:
December 20, 2019
Publication date:
April 23, 2020
Applicants:
ALK-ABELLÓ A/S, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Inventors:
Bjoern Peters, Gitte Lund, Lars Harder Christensen, Thomas Stranzl, Alessandro Sette
Abstract: Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).
Type:
Grant
Filed:
October 14, 2015
Date of Patent:
April 21, 2020
Assignees:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY
Inventors:
Nunzio Bottini, Jiwen Zou, Santhi R. Ganji, Stephanie Stanford, Anthony Pinkerton, Thomas D. Y. Chung, Michael Hedrick, Robert Ardecky
Abstract: Presented is a method for treating inflammation and autoimmune diseases through the use of a phosphatase rheumatoid arthritis (PT-PRA) antagonist.
Type:
Grant
Filed:
September 9, 2015
Date of Patent:
March 31, 2020
Assignees:
La Jolla Institute for Allergy & Immunology, The Regents of the University of California
Inventors:
Nunzio Bottini, Gary Firestein, Stephanie Stanford
Abstract: The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit iron a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk, of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.
Type:
Application
Filed:
June 4, 2018
Publication date:
March 26, 2020
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, LA JOLLA INSTITUTE FOR ALLERGY & IMMUNOLOGY, THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.
Inventors:
David Sulzer, Alessandro Sette, Cecilia Lindestam Arlehamn, John Pham, Bjoern Peters
Abstract: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.
Type:
Grant
Filed:
May 29, 2017
Date of Patent:
February 11, 2020
Assignees:
ALK ABELLÓ, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Inventors:
Bjoern Peters, Gitte Lund, Lars Harder Christensen, Thomas Stranzl, Alessandro Sette
Abstract: Provided herein are composition comprising novel epitopes of ApoB100, as well as sub-sequences, portions and modifications thereof, and uses thereof for treating adverse cardiovascular events, cardiovascular disease, atherosclerosis and certain liver disorders.
Type:
Application
Filed:
May 18, 2016
Publication date:
January 30, 2020
Applicant:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Abstract: The invention relates to Timothy Grass proteins and peptides, subsequences, portions, homologs, variants and derivatives thereof, and methods and uses of Timothy Grass proteins and peptides. Methods include, for example, modulating an immune response; protecting a subject against or treating a subject for an allergic response, allergic disorder or allergic disease; and inducing immunological tolerance to the allergen in a subject.
Type:
Grant
Filed:
February 7, 2013
Date of Patent:
October 1, 2019
Assignee:
La Jolla Institute For Allergy And Immunology
Inventors:
Alessandro Sette, Veronique Schulten, Howard Grey, Bjoern Peters, Jason Greenbaum
Abstract: The invention relates to novel targets for immune response modulation, treatment of tuberculosis infection and epitopes of Mycobacterium tuberculosis, or subsequences, portions or modifications thereof, and methods and compounds for treatment and prevention of tuberculosis infection.
Type:
Grant
Filed:
April 9, 2015
Date of Patent:
September 10, 2019
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Abstract: The compounds, compositions and methods provided herein antagonize, inhibit, decrease, reduce, suppress, or disrupt CD1d-mediated, iNKT cell-mediated, and/or iNKT cell TCR-mediated immune signaling. The sphingamide compounds were rationally designed based upon 3D structural considerations in relation to the structures of each of CD1d, the iNKT cell TCR, and the ternary complex CD1d-a-GalCer analog lipids-TCR. More specifically, the addition of an amide in the phytosphingosine tail of a derivative of ?-GalCer led to a non-conserved binding with CD1d, a conserved binding with the iNKT cell TCR, and an antagonist-like phenotype.
Type:
Application
Filed:
November 14, 2016
Publication date:
August 22, 2019
Applicants:
La Jolla Institute for Allergy and Immunology, Universiteit Gent, VIB VZW
Inventors:
Dirk Zajonc, Serge Van Calenbergh, Dirk Elewaut, Joren Guillaume
Abstract: There are provided, inter alia, methods and compositions to treat autoimmune disease including invasiveness of fibroblast-like synoviocytes in rheumatoid arthritis.
Type:
Grant
Filed:
November 10, 2015
Date of Patent:
August 20, 2019
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Abstract: Methods of treating a food allergy, allergic reactions, hypersensitivity, inflammatory responses, inflammation are provided. In one method, histamine releasing factor (HRF)/translationally controlled tumor protein (TCTP) is contacted with a compound that inhibits or reduces binding of HRF/TCTP to an immunoglobulin in order to treat the food allergy, allergic reaction, hypersensitivity, inflammatory response, or inflammation. Methods of reducing or decreasing the probability, severity, frequency, duration or preventing a subject from having an acute or chronic food allergy, allergic reaction, hypersensitivity, an inflammatory response or inflammation, are also provided.
Type:
Grant
Filed:
August 18, 2014
Date of Patent:
August 6, 2019
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Abstract: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.
Type:
Application
Filed:
May 29, 2017
Publication date:
July 4, 2019
Applicants:
ALK-ABELLÓ A/S, LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Inventors:
Bjoern Peters, Gitte Lund, Lars Harder Christensen, Thomas Stranzl, Alessandro Sette
Abstract: Dengue virus (DV) peptides, including T cell epitopes, structural and non-structural (NS) polypeptide sequences, subsequences and modifications thereof, nucleotide sequences encoding such peptides, and compositions including such peptides and encoding nucleotide sequences, and cells expressing such peptides, are provided. Such DV peptides, nucleotide sequences and compositions, can be used to elicit, stimulate, induce, promote, increase, enhance or activate an anti-DV CD8+ T cell response or an anti-DV CD4+ T cell response. Such peptides, nucleotide sequences and compositions can also be used for and in methods of vaccination/immunization of a subject against Dengue virus (DV) (e.g., to provide protection against DV infection and/or pathology), and for treatment of a subject in need thereof, for example, treatment of the subject for a Dengue virus (DV) infection or pathology.
Type:
Grant
Filed:
July 15, 2015
Date of Patent:
June 4, 2019
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Abstract: The invention provides HVEM cis complexes which include, for example, HVEM/BTLA, HVEM/CD160 and HVEM/gD cis complexes. The invention provides ligands and agents that bind to HVEM cis complexes, such as antibodies. The invention further provides methods of use of the HVEM cis complexes, and the ligands and agents (e.g., LIGHT polypeptide sequence) that bind to the HVEM cis complexes.
Type:
Grant
Filed:
February 7, 2014
Date of Patent:
March 5, 2019
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
Inventors:
Carl F. Ware, Timothy C. Cheung, Marcos Steinberg
Abstract: The present disclosure relates to methods and compositions useful for initiating and propagating ICOS-mediated signaling. In particular, the present disclosure provides three peptide motifs which promote ICOS binding and whose ablation leads to modulated ICOS signaling and modulated signaling mediated by TBK1, IRF4, IKK?, or TBKBP1. The binding of these peptide motifs or the addition of such motifs as co-stimulatory agents leads to modulated immune responses, and provides new and unexpected therapies for neurodegenerative, autoimmune, metabolic, cancer inflammatory, or immunodeficiency conditions, diseases, or disorders.
Type:
Application
Filed:
December 16, 2016
Publication date:
December 27, 2018
Applicant:
La Jolla Institute for Allergy and Immunology
Abstract: The invention relates to compositions, methods and uses of inhibitors of binding between PKC? and CD28, and modulating an undesirable or aberrant immune response, disorder or disease, an inflammatory response, disorder or disease, inflammation or an autoimmune response, disorder or disease. Compositions include inhibitors of binding between PKC? and CD28, which include, among others, PKC?, CD28 and Lck sequences, subsequences, variants and modified forms, and polymorphisms.
Type:
Application
Filed:
March 7, 2018
Publication date:
November 22, 2018
Applicant:
La Jolla Institute for Allergy and Immunology
Abstract: The present invention relates to a method and a medicament for airway and/or lung diseases such as moderate and/or severe asthma disease, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and systemic sclerosis. The medicament contains an agent which inhibits TL1A-DR3 interaction, and the method involves administering an effective amount of the agent to a subject to inhibit at least one symptom, feature or condition selected from hyperplasia of epithelial cells, epithelial metaplasia, hypertrophy of smooth muscle cells, and hyperproliferation of smooth muscle cells, production of extracellular matrix, and/or airway and/or lung tissue remodeling.
Type:
Application
Filed:
November 2, 2016
Publication date:
November 8, 2018
Applicants:
La Jolla Institute for Allergy & Immunology, KYOWA HAKKO KIRIN CO., LTD
Inventors:
Michael CROFT, Rana HERRO, David MILLS, Rachel SOLOFF NUGENT, Monica LEUNG
Abstract: Disclosed herein are methods of increasing numbers of monocytes to a tumor or cancer metastasis site in a subject. Non-limiting embodiments include administering or using a Nur77 polypeptide or subsequence thereof; a Nur77 agonist; a CX3CR1 agonist; CD14+ CD16+ monocytes and/or CD14dimCD16+(CD115+CD11b+GR1?(Ly6C?)) monocytes; CD14+CD16+ monocytes and/or CD14dimCD16+(CD115+CD11b+GR1?(Ly6C?)) monocytes contacted with a Nur77 agonist or contacted with a CX3CR1 agonist. Also disclosed herein are methods of increasing, stimulating, activating or promoting monocyte migration to or mobilization against a tumor or cancer metastasis in a subject. Non-limiting embodiments include administering a Nur77 polypeptide or sub-sequence thereof; a Nur77 agonist; a CX3CR1 agonist; CD14+ CD16+ monocytes and/or CD14dimCD16+(CD115+CD11b+GR1? (Ly6C?)) monocytes; or CD14+CD16+ monocytes and/or CD14dimCD16+(CD115+CD11b+GR1?(Ly6C?)) monocytes contacted with a Nur77 agonist or contacted with a CX3CR1 agonist.
Type:
Application
Filed:
October 27, 2016
Publication date:
November 1, 2018
Applicant:
La Jolla Institute for Allergy and Immunology
Abstract: The invention relates to compositions and methods that employ OX40 (CD134), a TNFR superfamily protein, agonists. The invention includes among other things administering an OX40 agonist alone or in combination with a viral antigen, or live or attenuated virus, to treat a viral infection, or for vaccination or immunization.
Type:
Grant
Filed:
October 4, 2007
Date of Patent:
October 23, 2018
Assignee:
La Jolla Institute for Allergy and Immunology
Inventors:
Michael Croft, Shahram Salek-Ardakani, Magdalini Moutaftsi, Alessandro Sette, Carl F. Ware