Patents Assigned to LA (Linear Adjustment) Dev. Limited
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Publication number: 20250257075Abstract: The present invention relates to compounds of formula (I), wherein R1 to R7, A1 and A2 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.Type: ApplicationFiled: December 19, 2024Publication date: August 14, 2025Applicant: Hoffmann-La Roche Inc.Inventors: Jianguo CHEN, Haixia LIU, Hong SHEN, Weixing ZHANG, Wei ZHU
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Publication number: 20250257104Abstract: Herein is reported a composition for the targeted delivery of large nucleic acids to the nucleus of a eukaryotic cell comprising non-covalent complexes of histones in form of assembled nucleosomes, a large nucleic acid, a hapten, and a bispecific binder that has a first binding specificity to the hapten and a second binding specificity to a cell-surface target present on the eukaryotic cell, wherein the histone and/or the nucleic acid is/are covalently bound/conjugated to the hapten, the histone and the large nucleic acid are associated (non-covalently) with each other/form a non-covalent complex, and the hapten and the bispecific binder are associated with each other/bound to each other by the first binding specificity of the bispecific binder.Type: ApplicationFiled: April 29, 2025Publication date: August 14, 2025Applicant: Hoffmann-La Roche Inc.Inventors: Ulrich BRINKMANN, Tobias KILLIAN
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Patent number: 12387901Abstract: A system for performing surface analysis on a material, includes a pulsed electron source that forms a monochromatic beam of incident electrons; means for conveying the incident electrons to the surface of a sample of material, so as to form backscattered electrons, and the backscattered electrons to detecting means, the conveying means comprising at least one electron optical system; means for detecting the backscattered electrons; the pulsed electron source comprising: a source of atoms; a continuous-wave laser beam configured to form a laser excitation zone able to excite the atoms to Rydberg states; a pulsed electric field on either side of the laser excitation zone, the pulsed electric field being configured to ionize at least the excited atoms and to form a monochromatic beam of electrons.Type: GrantFiled: April 28, 2021Date of Patent: August 12, 2025Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SACLAYInventors: Daniel Comparat, Nicholas Barrett, Lionel Amiaud, Yan Picard, Anne Lafosse, Raphaël Hahn, Olena Fedchenko, Gerd Schoenhense
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Patent number: 12385014Abstract: The invention relates to a method for producing a recombinant baculovirus comprising n exogenous genes in an insect cell, by means of homologous recombination of a replication-deficient baculovirus genome and n transfer vectors, each comprising one of the n exogenous genes, n being an integer at least equal to 2.Type: GrantFiled: August 4, 2017Date of Patent: August 12, 2025Assignees: CENTRE NATIONAL DEL LA RECHERCH SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMQIUEInventors: Martine Cerutti, Sylvie Juliant, Sylvie Thery
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Publication number: 20250250240Abstract: The invention relates to a compound of the following formula (I) in which X is an anion, in which R1 and R2 are either together —CH3 or a C1-C4 alkyl such that, if R1 is a Cn+i alkyl, R2 is a Cn alkyl, and vice versa, n being an integer ranging from 1 to 3, i being an integer ranging from 1 to 3 and in which n+i ranges from 1 to 4; and in which R3 is a —CH3 or a C2-C8 alkyl, said C2-C8 alkyl being optionally substituted with one or more heteroatoms.Type: ApplicationFiled: January 23, 2023Publication date: August 7, 2025Applicants: UNIVERSITE D'AIX-MARSEILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ETAT FRANCAIS (MINIATÉRE DES ARMÉES) REPRÉSENTÉ PAR LA DIRECTION CENTRALE DU SERVICE DE SANTÉ DES ARInventors: Frédéric BRUNEL, Oliver SIRI, Serhii KRYKUN, Mrunal PATIL, Michel CAMPLO, Jean-Michel BOLLA, Jean-Manuel RAIMUNDO, Frédéric GARZINO, Eric GARNOTEL
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Publication number: 20250250284Abstract: The present invention relates to compounds of formula (I), wherein R1 to R6, A1 and A2 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.Type: ApplicationFiled: January 3, 2025Publication date: August 7, 2025Applicant: Hoffmann-La Roche Inc.Inventors: Jianguo CHEN, Haixia LIU, Hong SHEN, Weixing ZHANG, Dan ZHAO, Wei ZHU
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Publication number: 20250251345Abstract: A method for fluorescence microscopic imaging of an object may be performed by means of a fluorescence microscopic imaging system with light sheet illumination. The method includes generating a line of light and scanning the line of light to generate a light sheet and further includes performing a wavefront analysis on an analysis field of the object. The method further includes applying spatial filtering of the fluorescence light, where the spatial filtering includes scanning a filtering element with respect to a fluorescence image of the line of light formed in a filtering plane of the filtering element. The scanning of the filtering element may be synchronized with the scanning of the line of light such as to obtain a superposition, at each instant, of the filtering element and the fluorescence image of the line of light.Type: ApplicationFiled: March 31, 2023Publication date: August 7, 2025Applicants: IMAGINE OPTIC, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMEIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, Paris Sciences et LettresInventors: Fabrice Harms, Xavier Levecq, Alexandra Fragaola
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Publication number: 20250250559Abstract: Herein is reported a method for determining the introduction of a nucleic acid into the genome of a mammalian cell, whereby the mammalian cell comprises one or two transcriptionally active alleles of a DPH1, DPH2, DPH4 and/or DPH5 gene, comprising the steps of transfecting the mammalian cell with one or more plasmids comprising the nucleic acid to be introduced, and the elements required for gene editing of said DPH gene, cultivating the transfected cell in the presence of a DPH gene transcription sensitive toxin, and thereby determining the introduction of a nucleic acid into the genome of the mammalian cell if the transfected cells is viable in the presence of the toxin.Type: ApplicationFiled: September 13, 2024Publication date: August 7, 2025Applicant: Hoffmann-La Roche Inc.Inventors: Ulrich Brinkmann, Tobias Killian
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Patent number: 12379337Abstract: A device and method for measuring angles of orientation of an x-ray imaging system including an x-ray source, an x-ray detector and a sample holder arranged to receive a sample to be analysed. The method includes: emitting a polychromatic x-ray beam through a reference sample installed on the sample holder in order to form a diffraction pattern on the sensing area of the x-ray detector, generating, with the x-ray detector, an observed image comprising the diffraction pattern, and determining the orientation of the x-ray source and the orientation of the x-ray detector by comparing the observed image with at least one target image comprising a diffraction pattern obtained for the reference sample with preset orientations of the x-ray source and of the x-ray detector.Type: GrantFiled: November 26, 2020Date of Patent: August 5, 2025Assignees: SAFRAN/Association pour la Recherche et le, Développement des Méthodes et Processus IndustrielsInventors: Edward Romero, Alexiane Arnaud, Clément Remacha, Henry Proudhon
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Patent number: 12378551Abstract: The present invention relates to methods of administering to a subject multimeric oligonucleotides having monomeric subunits joined by linkers. The multimeric oligonucleotides have a molecular weight of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present invention also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides.Type: GrantFiled: July 1, 2021Date of Patent: August 5, 2025Assignee: MPEG LA, L.L.C.Inventors: Jonathan Miles Brown, Kristin K. H. Neuman, Hans-Peter Vornlocher, Philipp Hadwiger
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Patent number: 12378325Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CHI and CL domains, said mutations preventing heavy chain/light chain mispairing.Type: GrantFiled: August 18, 2020Date of Patent: August 5, 2025Assignees: Centre National de la Recherche Scientifique, Universite de LausanneInventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
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Patent number: 12377066Abstract: The present invention relates to the field of neonatal cholestasis, in particular the treatment of neonatal biliary atresia or diseases associated with biliary system destruction. Also, the invention relates to methods and/or compounds for treating or preventing biliary atresia or disease associated with biliary system destruction. It further relates to methods and/or compounds for slowing the progression of biliary atresia or disease associated with biliary system destruction.Type: GrantFiled: October 11, 2019Date of Patent: August 5, 2025Assignees: Assistance Publique-Hopitaux de Paris, Centre National De La Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de ParisInventors: Ganna Panasyuk, Muriel Girard
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Patent number: 12378315Abstract: Herein is reported an antibody binding to rabbit CD19 comprising (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 32 or 33 or 34, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 35 or 36, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 37, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO: 38, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO: 39, and (f) a HVR-L3 comprising the amino acid sequence of SEQ ID NO: 40, as well as methods of using the same, especially in the identification and selection of antibody producing rabbit B-cells.Type: GrantFiled: June 29, 2021Date of Patent: August 5, 2025Assignee: Hoffmann-La Roche Inc.Inventors: Alexander Haas, Friederike Jung, Stefan Klostermann, Sonja Offner
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Publication number: 20250241852Abstract: The present invention provides methods to prevent the formation of visible particles in aqueous protein formulations, as well as compositions and pharmaceutical products obtained with said method.Type: ApplicationFiled: March 5, 2025Publication date: July 31, 2025Applicant: Hoffmann-La Roche Inc.Inventor: Andrea ALLMENDINGER
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Publication number: 20250247278Abstract: Apparatus, systems, and methods for a transmitter array for enhanced communication systems may be provided. According to an aspect a transmitter array may be provided. The transmitter array may include a plurality of equivalent transmitter units. Each equivalent transmitter unit may include an antenna and a QPSK modulator. Each equivalent transmitter unit may be selectively activatable. In some embodiments, upon activation of a set of equivalent transmitter units selected from the plurality of equivalent transmitter units, a desired modulated output signal is generated. According to another aspect, a method of generating a desired modulated output signal may be provided. The method may include receiving a plurality of local oscillator (LO) signals at a transmitter array. The method may further include selectively activating a set of equivalent transmitter units of the plurality of equivalent transmitter units to generate the desired modulated output signal.Type: ApplicationFiled: January 25, 2024Publication date: July 31, 2025Applicants: HUAWEI TECHNOLOGIES CANADA CO., LTD., la Corporation de l'École Polytechnique de MontréalInventors: Yasser BIGDELI, Pascal BURASA, Ke WU
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Publication number: 20250246661Abstract: A method for electrochemically activating a material comprising hydronium ion-conducting amyloid fibers and glycosylated proteins, in which the method includes placing at least part of the material in contact with a water vapor, electrolyzing at least part of the water vapor which is in contact with the material, and obtaining an activated material. The invention also relates to an activated material obtained in this way and to it use for generating electrical energy.Type: ApplicationFiled: May 3, 2023Publication date: July 31, 2025Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, IFREMER - INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MERInventors: Vincent FORGE, Joffrey CHAMPAVERT, Julien HURTAUD, Herlé GORAGUER, Adina MOROZAN
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Patent number: 12371741Abstract: The present disclosure relates to a method for detecting a mutation in a microsatellite sequence locus of a target fragment from a DNA sample, comprising a step of subjecting said DNA sample to a digital polymerase chain reaction (PCR) in the presence of a PCR solution comprising: a pair of primers suitable for amplifying said target fragment of the DNA sample including said microsatellite sequence; a first MS oligonucleotide (MS) hydrolysis probe, labeled with a first fluorophore, wherein said first MS oligonucleotide probe is complementary to a wild-type sequence including the microsatellite sequence; a second oligonucleotide reference (REF) hydrolysis probe, labeled with a second fluorophore, wherein said second oligonucleotide REF probe is complementary to a wild-type sequence of said target DNA fragment which does not include said microsatellite sequence.Type: GrantFiled: February 6, 2024Date of Patent: July 29, 2025Assignees: Institut Curie, Institut National de la Sante et de la Recherche Medicale, Universite de Versailles Saint-Quentin-en-YvelinesInventors: Charlotte Proudhon, Amélie Kasperek, Amanda Bortolini Silveira, François-Clément Bidard, Marc-Henri Stern
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Patent number: 12371748Abstract: Genotyping methods and compositions for selecting patients with cardiovascular disease who will benefit from treatment with HDL-raising or HDL mimicking agent, in particular with a CETP inhibitor/modulator.Type: GrantFiled: June 16, 2022Date of Patent: July 29, 2025Assignee: Hoffmann-La Roche Inc.Inventors: Marie-Pierre Dube, Jean-Claude Tardif
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Patent number: 12371402Abstract: The invention relates to compounds of formula (I) as follows: (I) wherein X1 and X2, identical or different, are NR5 or a sulfur atom, Y is a group (C1-C10)alkanediyl, Ar1 and Ar2, identical or different, are an aryl group optionally substituted by one or several groups selected from a halogen atom, a (C1-C6) alkyl, —OR1, —NR1R2 and —COOR3? with R1 and R2, independently of each other, are a hydrogen atom, a (C-1-C6) alkyl group or a —COR3 group, R3 and R4? independently of each other, are a hydrogen atom or a (C1-C6) alkyl group, and R5 is a hydrogen atom or a (C1-C6)alkyl group, or a pharmaceutically acceptable salt and/or solvate thereof, in particular for use in cancer treatment.Type: GrantFiled: November 28, 2019Date of Patent: July 29, 2025Assignees: CENTRE LEON BERARD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE GRENOBLE ALPES, UNIVERSITE DE CAEN NORMANDIEInventors: Marc Billaud, Renaud Prudent, Martine Cordier-Bussat, Eric Fontaine, Patrick Dallemagne, Peggy Suzanne, Sylvain Rault
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Patent number: D1085869Type: GrantFiled: July 13, 2023Date of Patent: July 29, 2025Assignee: LABORATOIRES LA PRAIRIE SAInventors: Davide Bordogna, Tobias Fricker