Patents Assigned to LA (Linear Adjustment) Dev. Limited
  • Publication number: 20250257075
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R7, A1 and A2 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 19, 2024
    Publication date: August 14, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jianguo CHEN, Haixia LIU, Hong SHEN, Weixing ZHANG, Wei ZHU
  • Publication number: 20250257104
    Abstract: Herein is reported a composition for the targeted delivery of large nucleic acids to the nucleus of a eukaryotic cell comprising non-covalent complexes of histones in form of assembled nucleosomes, a large nucleic acid, a hapten, and a bispecific binder that has a first binding specificity to the hapten and a second binding specificity to a cell-surface target present on the eukaryotic cell, wherein the histone and/or the nucleic acid is/are covalently bound/conjugated to the hapten, the histone and the large nucleic acid are associated (non-covalently) with each other/form a non-covalent complex, and the hapten and the bispecific binder are associated with each other/bound to each other by the first binding specificity of the bispecific binder.
    Type: Application
    Filed: April 29, 2025
    Publication date: August 14, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich BRINKMANN, Tobias KILLIAN
  • Patent number: 12387901
    Abstract: A system for performing surface analysis on a material, includes a pulsed electron source that forms a monochromatic beam of incident electrons; means for conveying the incident electrons to the surface of a sample of material, so as to form backscattered electrons, and the backscattered electrons to detecting means, the conveying means comprising at least one electron optical system; means for detecting the backscattered electrons; the pulsed electron source comprising: a source of atoms; a continuous-wave laser beam configured to form a laser excitation zone able to excite the atoms to Rydberg states; a pulsed electric field on either side of the laser excitation zone, the pulsed electric field being configured to ionize at least the excited atoms and to form a monochromatic beam of electrons.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: August 12, 2025
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SACLAY
    Inventors: Daniel Comparat, Nicholas Barrett, Lionel Amiaud, Yan Picard, Anne Lafosse, Raphaël Hahn, Olena Fedchenko, Gerd Schoenhense
  • Patent number: 12385014
    Abstract: The invention relates to a method for producing a recombinant baculovirus comprising n exogenous genes in an insect cell, by means of homologous recombination of a replication-deficient baculovirus genome and n transfer vectors, each comprising one of the n exogenous genes, n being an integer at least equal to 2.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 12, 2025
    Assignees: CENTRE NATIONAL DEL LA RECHERCH SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMQIUE
    Inventors: Martine Cerutti, Sylvie Juliant, Sylvie Thery
  • Publication number: 20250250240
    Abstract: The invention relates to a compound of the following formula (I) in which X is an anion, in which R1 and R2 are either together —CH3 or a C1-C4 alkyl such that, if R1 is a Cn+i alkyl, R2 is a Cn alkyl, and vice versa, n being an integer ranging from 1 to 3, i being an integer ranging from 1 to 3 and in which n+i ranges from 1 to 4; and in which R3 is a —CH3 or a C2-C8 alkyl, said C2-C8 alkyl being optionally substituted with one or more heteroatoms.
    Type: Application
    Filed: January 23, 2023
    Publication date: August 7, 2025
    Applicants: UNIVERSITE D'AIX-MARSEILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ETAT FRANCAIS (MINIATÉRE DES ARMÉES) REPRÉSENTÉ PAR LA DIRECTION CENTRALE DU SERVICE DE SANTÉ DES AR
    Inventors: Frédéric BRUNEL, Oliver SIRI, Serhii KRYKUN, Mrunal PATIL, Michel CAMPLO, Jean-Michel BOLLA, Jean-Manuel RAIMUNDO, Frédéric GARZINO, Eric GARNOTEL
  • Publication number: 20250250284
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R6, A1 and A2 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 3, 2025
    Publication date: August 7, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jianguo CHEN, Haixia LIU, Hong SHEN, Weixing ZHANG, Dan ZHAO, Wei ZHU
  • Publication number: 20250251345
    Abstract: A method for fluorescence microscopic imaging of an object may be performed by means of a fluorescence microscopic imaging system with light sheet illumination. The method includes generating a line of light and scanning the line of light to generate a light sheet and further includes performing a wavefront analysis on an analysis field of the object. The method further includes applying spatial filtering of the fluorescence light, where the spatial filtering includes scanning a filtering element with respect to a fluorescence image of the line of light formed in a filtering plane of the filtering element. The scanning of the filtering element may be synchronized with the scanning of the line of light such as to obtain a superposition, at each instant, of the filtering element and the fluorescence image of the line of light.
    Type: Application
    Filed: March 31, 2023
    Publication date: August 7, 2025
    Applicants: IMAGINE OPTIC, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMEIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, Paris Sciences et Lettres
    Inventors: Fabrice Harms, Xavier Levecq, Alexandra Fragaola
  • Publication number: 20250250559
    Abstract: Herein is reported a method for determining the introduction of a nucleic acid into the genome of a mammalian cell, whereby the mammalian cell comprises one or two transcriptionally active alleles of a DPH1, DPH2, DPH4 and/or DPH5 gene, comprising the steps of transfecting the mammalian cell with one or more plasmids comprising the nucleic acid to be introduced, and the elements required for gene editing of said DPH gene, cultivating the transfected cell in the presence of a DPH gene transcription sensitive toxin, and thereby determining the introduction of a nucleic acid into the genome of the mammalian cell if the transfected cells is viable in the presence of the toxin.
    Type: Application
    Filed: September 13, 2024
    Publication date: August 7, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Tobias Killian
  • Patent number: 12379337
    Abstract: A device and method for measuring angles of orientation of an x-ray imaging system including an x-ray source, an x-ray detector and a sample holder arranged to receive a sample to be analysed. The method includes: emitting a polychromatic x-ray beam through a reference sample installed on the sample holder in order to form a diffraction pattern on the sensing area of the x-ray detector, generating, with the x-ray detector, an observed image comprising the diffraction pattern, and determining the orientation of the x-ray source and the orientation of the x-ray detector by comparing the observed image with at least one target image comprising a diffraction pattern obtained for the reference sample with preset orientations of the x-ray source and of the x-ray detector.
    Type: Grant
    Filed: November 26, 2020
    Date of Patent: August 5, 2025
    Assignees: SAFRAN/Association pour la Recherche et le, Développement des Méthodes et Processus Industriels
    Inventors: Edward Romero, Alexiane Arnaud, Clément Remacha, Henry Proudhon
  • Patent number: 12378551
    Abstract: The present invention relates to methods of administering to a subject multimeric oligonucleotides having monomeric subunits joined by linkers. The multimeric oligonucleotides have a molecular weight of at least about 45 kD and other characteristics, such that their clearance due to glomerular filtration is reduced. The present invention also relates to such multimeric oligonucleotides and methods of synthesizing such multimeric oligonucleotides.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: August 5, 2025
    Assignee: MPEG LA, L.L.C.
    Inventors: Jonathan Miles Brown, Kristin K. H. Neuman, Hans-Peter Vornlocher, Philipp Hadwiger
  • Patent number: 12378325
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CHI and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: August 5, 2025
    Assignees: Centre National de la Recherche Scientifique, Universite de Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Patent number: 12377066
    Abstract: The present invention relates to the field of neonatal cholestasis, in particular the treatment of neonatal biliary atresia or diseases associated with biliary system destruction. Also, the invention relates to methods and/or compounds for treating or preventing biliary atresia or disease associated with biliary system destruction. It further relates to methods and/or compounds for slowing the progression of biliary atresia or disease associated with biliary system destruction.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 5, 2025
    Assignees: Assistance Publique-Hopitaux de Paris, Centre National De La Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Paris
    Inventors: Ganna Panasyuk, Muriel Girard
  • Patent number: 12378315
    Abstract: Herein is reported an antibody binding to rabbit CD19 comprising (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 32 or 33 or 34, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 35 or 36, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 37, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO: 38, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO: 39, and (f) a HVR-L3 comprising the amino acid sequence of SEQ ID NO: 40, as well as methods of using the same, especially in the identification and selection of antibody producing rabbit B-cells.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: August 5, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Haas, Friederike Jung, Stefan Klostermann, Sonja Offner
  • Publication number: 20250241852
    Abstract: The present invention provides methods to prevent the formation of visible particles in aqueous protein formulations, as well as compositions and pharmaceutical products obtained with said method.
    Type: Application
    Filed: March 5, 2025
    Publication date: July 31, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventor: Andrea ALLMENDINGER
  • Publication number: 20250247278
    Abstract: Apparatus, systems, and methods for a transmitter array for enhanced communication systems may be provided. According to an aspect a transmitter array may be provided. The transmitter array may include a plurality of equivalent transmitter units. Each equivalent transmitter unit may include an antenna and a QPSK modulator. Each equivalent transmitter unit may be selectively activatable. In some embodiments, upon activation of a set of equivalent transmitter units selected from the plurality of equivalent transmitter units, a desired modulated output signal is generated. According to another aspect, a method of generating a desired modulated output signal may be provided. The method may include receiving a plurality of local oscillator (LO) signals at a transmitter array. The method may further include selectively activating a set of equivalent transmitter units of the plurality of equivalent transmitter units to generate the desired modulated output signal.
    Type: Application
    Filed: January 25, 2024
    Publication date: July 31, 2025
    Applicants: HUAWEI TECHNOLOGIES CANADA CO., LTD., la Corporation de l'École Polytechnique de Montréal
    Inventors: Yasser BIGDELI, Pascal BURASA, Ke WU
  • Publication number: 20250246661
    Abstract: A method for electrochemically activating a material comprising hydronium ion-conducting amyloid fibers and glycosylated proteins, in which the method includes placing at least part of the material in contact with a water vapor, electrolyzing at least part of the water vapor which is in contact with the material, and obtaining an activated material. The invention also relates to an activated material obtained in this way and to it use for generating electrical energy.
    Type: Application
    Filed: May 3, 2023
    Publication date: July 31, 2025
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, IFREMER - INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER
    Inventors: Vincent FORGE, Joffrey CHAMPAVERT, Julien HURTAUD, Herlé GORAGUER, Adina MOROZAN
  • Patent number: 12371741
    Abstract: The present disclosure relates to a method for detecting a mutation in a microsatellite sequence locus of a target fragment from a DNA sample, comprising a step of subjecting said DNA sample to a digital polymerase chain reaction (PCR) in the presence of a PCR solution comprising: a pair of primers suitable for amplifying said target fragment of the DNA sample including said microsatellite sequence; a first MS oligonucleotide (MS) hydrolysis probe, labeled with a first fluorophore, wherein said first MS oligonucleotide probe is complementary to a wild-type sequence including the microsatellite sequence; a second oligonucleotide reference (REF) hydrolysis probe, labeled with a second fluorophore, wherein said second oligonucleotide REF probe is complementary to a wild-type sequence of said target DNA fragment which does not include said microsatellite sequence.
    Type: Grant
    Filed: February 6, 2024
    Date of Patent: July 29, 2025
    Assignees: Institut Curie, Institut National de la Sante et de la Recherche Medicale, Universite de Versailles Saint-Quentin-en-Yvelines
    Inventors: Charlotte Proudhon, Amélie Kasperek, Amanda Bortolini Silveira, François-Clément Bidard, Marc-Henri Stern
  • Patent number: 12371748
    Abstract: Genotyping methods and compositions for selecting patients with cardiovascular disease who will benefit from treatment with HDL-raising or HDL mimicking agent, in particular with a CETP inhibitor/modulator.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: July 29, 2025
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marie-Pierre Dube, Jean-Claude Tardif
  • Patent number: 12371402
    Abstract: The invention relates to compounds of formula (I) as follows: (I) wherein X1 and X2, identical or different, are NR5 or a sulfur atom, Y is a group (C1-C10)alkanediyl, Ar1 and Ar2, identical or different, are an aryl group optionally substituted by one or several groups selected from a halogen atom, a (C1-C6) alkyl, —OR1, —NR1R2 and —COOR3? with R1 and R2, independently of each other, are a hydrogen atom, a (C-1-C6) alkyl group or a —COR3 group, R3 and R4? independently of each other, are a hydrogen atom or a (C1-C6) alkyl group, and R5 is a hydrogen atom or a (C1-C6)alkyl group, or a pharmaceutically acceptable salt and/or solvate thereof, in particular for use in cancer treatment.
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: July 29, 2025
    Assignees: CENTRE LEON BERARD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE GRENOBLE ALPES, UNIVERSITE DE CAEN NORMANDIE
    Inventors: Marc Billaud, Renaud Prudent, Martine Cordier-Bussat, Eric Fontaine, Patrick Dallemagne, Peggy Suzanne, Sylvain Rault
  • Patent number: D1085869
    Type: Grant
    Filed: July 13, 2023
    Date of Patent: July 29, 2025
    Assignee: LABORATOIRES LA PRAIRIE SA
    Inventors: Davide Bordogna, Tobias Fricker