Abstract: The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
Type:
Grant
Filed:
September 17, 2020
Date of Patent:
February 7, 2023
Assignee:
Hoffman-La Rocher Inc.
Inventors:
Stefan Dengl, Thomas Emrich, Guy Georges, Ulrich Goepfert, Fiona Grueninger, Adrian Hugenmatter, Anton Jochner, Hubert Kettenberger, Joerg Moelleken, Ekkehard Moessner, Olaf Mundigl, Jens Niewoehner, Tilman Schlothauer, Michael Molhoj, Kevin Brady
Abstract: Compounds of the formula:
are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
Type:
Grant
Filed:
April 5, 2002
Date of Patent:
October 19, 2004
Assignee:
Hoffmann-La Rocher Inc.
Inventors:
Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull