Patents Assigned to Laboratoires Fournier S.A.
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Patent number: 8436040Abstract: Indole compounds corresponding to the formula (I): as defined in the claims, pharmaceutically acceptable addition salts of such compounds, pharmaceutical compositions containing such compounds, the process for their preparation, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular disease, inflammatory disease and neurodegeneration.Type: GrantFiled: June 7, 2010Date of Patent: May 7, 2013Assignee: Laboratoires Fournier S.A.Inventors: Jean Binet, Benaiessa Boubia, Pierre Dodey, Christiane Legendre, Martine Barth, Olivia Poupardin-Olivier
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Patent number: 8329214Abstract: The invention provides processes using suspensions to produce fenofibrate compositions. The resulting fenofibrate compositions can be made in the form of a tablet.Type: GrantFiled: March 21, 2007Date of Patent: December 11, 2012Assignee: Laboratoires Fournier S.A.Inventors: Andre Stamm, Pawan Seth
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Patent number: 8093394Abstract: The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.Type: GrantFiled: March 26, 2009Date of Patent: January 10, 2012Assignee: Laboratoires Fournier S.A.Inventors: Véronique Barberousse, Didier Thomas, Michel Bondoux
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Patent number: 8030335Abstract: The present invention generally relates to a novel therapeutical use of liver X receptor (LXR) agonsits. More specifically, the present invention relates to the use of LXR agonist for the preparation of a medicament useful for the treatment and/or the prevention of a disease associated with beta cells degeneration, such as diabetes, and a method for increasing ex vivo viability of pancreatic islet cells, comprising contacting said islet cells with a LXR agonist.Type: GrantFiled: May 10, 2006Date of Patent: October 4, 2011Assignee: Laboratoires Fournier S.A.Inventors: Bernadette Husson, Pierre Broqua, Jean-Louis Junien
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Patent number: 8013010Abstract: Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.Type: GrantFiled: March 26, 2009Date of Patent: September 6, 2011Assignee: Laboratoires Fournier S.A.Inventors: Véronique Barberousse, Didier Thomas, Michel Bondoux
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Patent number: 7976869Abstract: The present invention relates to a novel galenic formulation of fenofibrate for oral administration and to the process for its preparation. According to the invention, the formulation is a tablet obtained by compressing a mixture comprising: a) granules containing: 1 to 5% of a surfactant; micronized fenofibrate; and at least one solid excipient selected from starch, cellulose and derivatives thereof, with the exception of C12 disaccharides, said granules being obtained by granulating the mixture with the aid of an aqueous solution of polyvinylpyrrolidone; b) crosslinked polyvinylpyrrolidone; and c) optionally flow aids or lubricants, the amount of fenofibrate being greater than 50% by weight, expressed relative to the weight of the tablet.Type: GrantFiled: October 21, 2009Date of Patent: July 12, 2011Assignee: Laboratoires Fournier S.A.Inventors: Pascale Blouquin, Philippe Reginault
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Publication number: 20100297761Abstract: A method of increasing the ex vivo viability of pancreatic islet cells comprising contacting the islet cells with a liver X receptor (LXR) agonist, particularly an LXRalpha agonist. Examples of especially useful LXR agonists include GW3965 and T0901317.Type: ApplicationFiled: May 26, 2010Publication date: November 25, 2010Applicant: LABORATOIRE FOURNIER S.A. French Limited CompanyInventors: Bernadette HUSSON, Pierre Broqua, Jean-Louis Junien
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Patent number: 7728002Abstract: A method of activating PPAR receptors in a subject, said method comprising administering to said subject an effective PPAR receptor activating amount of a pyrrolopyridine compound corresponding to formula (I): wherein R, R1, R2, R3, R4, X, Ar and n have defined meanings, or a pharmaceutically acceptable salt thereof, particularly as part of the treatment of a disorder or disease state selected from the group consisting of atherosclerosis, myocardial infarction, hypertension, and cerebral vascular disease.Type: GrantFiled: June 2, 2009Date of Patent: June 1, 2010Assignee: Laboratoires Fournier S.A.Inventors: Benaïssa Boubia, Martine Barth, Jean Binet, Pierre Dodey, Christiane Legendre, Olivia Poupardin-Olivier
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Publication number: 20100040682Abstract: The present invention relates to a novel galenic formulation of fenofibrate for oral administration and to the process for its preparation. According to the invention, the formulation is a tablet obtained by compressing a mixture comprising: a) granules containing: 1 to 5% of a surfactant; micronized fenofibrate; and at least one solid excipient selected from starch, cellulose and derivatives thereof, with the exception of C12 disaccharides, said granules being obtained by granulating the mixture with the aid of an aqueous solution of polyvinylpyrrolidone; b) crosslinked polyvinylpyrrolidone; and c) optionally flow aids or lubricants, the amount of fenofibrate being greater than 50% by weight, expressed relative to the weight of the tablet.Type: ApplicationFiled: October 21, 2009Publication date: February 18, 2010Applicant: LABORATOIRES FOURNIER S.A.Inventors: Pascale Blouquin, Philippe Reginault
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Patent number: 7652032Abstract: 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses.Type: GrantFiled: January 12, 2009Date of Patent: January 26, 2010Assignee: Laboratoires Fournier S.A.Inventors: Didier Thomas, Michel Bondoux, Véronique Barberousse, Vincent Peyrou
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Publication number: 20090239856Abstract: A method of activating PPAR receptors in a subject, said method comprising administering to said subject an effective PPAR receptor activating amount of a pyrrolopyridine compound corresponding to formula (I): wherein R, R1, R2, R3, R4, X, Ar and n have defined meanings, or a pharmaceutically acceptable salt thereof, particularly as part of the treatment of a disorder or disease state selected from the group consisting of atherosclerosis, myocardial infarction, hypertension, and cerebral vascular disease.Type: ApplicationFiled: June 2, 2009Publication date: September 24, 2009Applicant: LABORATOIRES FOURNIER S.A.Inventors: Benaissa Boubia, Martine Barth, Jean Binet, Pierre Dodey, Christiane Legendre, Olivia Poupardin-Olivier
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Publication number: 20090186840Abstract: Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.Type: ApplicationFiled: March 26, 2009Publication date: July 23, 2009Applicant: Laboratoires Fournier S.AInventors: Veronique BARBEROUSSE, Didier Thomas, Michel Bondoux
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Publication number: 20090182013Abstract: The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.Type: ApplicationFiled: March 26, 2009Publication date: July 16, 2009Applicant: Laboratoires Fournier S.A.Inventors: Veronique Barberousse, Didier Thomas, Michel Bondoux
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Patent number: 7557122Abstract: Pyrrolopyridine compounds corresponding to formula (I): as defined in the claims, pharmaceutically acceptable salts thereof, the process for preparing such compounds, pharmaceutical compositions containing such compounds, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular diseases, inflammatory diseases and neurodegenerative diseases.Type: GrantFiled: February 29, 2008Date of Patent: July 7, 2009Assignee: Laboratoires Fournier S.A.Inventors: Benaïssa Boubia, Martine Barth, Jean Binet, Pierre Dodey, Christiane Legendre, Olivia Poupardin-Olivier
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Publication number: 20090170939Abstract: This invention relates to the use of fenofibrate or a derivative thereof for the manufacture of a medicament for the prevention and/or treatment of retinopathy.Type: ApplicationFiled: November 10, 2006Publication date: July 2, 2009Applicant: Laboratoires Fournier S.A.Inventors: Jean-Claude Ansquer, Anthony Keech
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Patent number: 7538111Abstract: The present invention concerns novel benzenesulphonamide compounds, defined by formula I. Therapeutic compositions comprising the benzenesulphonamide compounds of the invention or salts thereof and methods for producing the benzenesulphonamide compounds of the invention are also disclosed. The benzenesulphonamide compounds of the invention or salts thereof are useful for treating pain, such as hyperalgesia and major algesia.Type: GrantFiled: March 24, 2004Date of Patent: May 26, 2009Assignee: Laboratoires Fournier S.A.Inventors: Martine Barth, Michel Bondoux, Pierre Dodey, Christine Massardier, Didier Thomas, Jean-Michel Luccarini
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Publication number: 20090118325Abstract: 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses.Type: ApplicationFiled: January 12, 2009Publication date: May 7, 2009Applicant: LABORATOIRES FOURNIER S.A.Inventors: Didier THOMAS, Michel Bondoux, Veronique Barberousse, Vincent Peyrou
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Publication number: 20090118306Abstract: The present invention generally relates to a novel therapeutical use of liver X receptor (LXR) agonsits. More specifically, the present invention relates to the use of LXR agonist for the preparation of a medicament useful for the treatment and/or the prevention of a disease associated with beta cells degeneration, such as diabetes, and a method for increasing ex vivo viability of pancreatic islet cells, comprising contacting said islet cells with a LXR agonist.Type: ApplicationFiled: May 10, 2006Publication date: May 7, 2009Applicant: LABORATOIRE FOURNIER S.A. French Limited CompayInventors: Bernadette Husson, Pierre Broqua, Jean-Louis Junien
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Patent number: 7465811Abstract: Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances, particularly for the treatment or inhibition of neurodegeneration, cardiovascular disease, inflammatory disease, hypercholesterolemia, dyslipidemia, obesity or diabetes.Type: GrantFiled: November 30, 2007Date of Patent: December 16, 2008Assignee: Laboratoires Fournier S.A.Inventors: Luc Lebreton, Christine Dumas, Christine Massardier, Michel Bondoux
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Publication number: 20080200495Abstract: Pyrrolopyridine compounds corresponding to formula (I): as defined in the claims, pharmaceutically acceptable salts thereof, the process for preparing such compounds, pharmaceutical compositions containing such compounds, and their use as pharmacologically active substances, especially in the treatment of hypertriglyceridemia, hyperlipidemia, hypercholesterolemia, diabetes, endothelial dysfunction, cardiovascular diseases, inflammatory diseases and neurodegenerative diseases.Type: ApplicationFiled: February 29, 2008Publication date: August 21, 2008Applicant: LABORATOIRES FOURNIER S.A.Inventors: Benaissa Boubia, Martine Barth, Jean Binet, Pierre Dodey, Christiane Legendre, Olivia Poupardin-Olivier