Patents Assigned to Laboratoires Prographarm
  • Patent number: 6106861
    Abstract: The invention relates to a rapidly disintegratable multiparticulate tablet which disintegrates in the mouth in less than 40 seconds and which comprises an excipient and an active ingredient in the form of microcrystals coated with a coating agent.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: August 22, 2000
    Assignee: Laboratoires Prographarm
    Inventors: Charles Chauveau, Edouard Gendrot, Alain Gilles Demichelis, Noureddine Nouri
  • Patent number: 6039979
    Abstract: The invention relates to a multiparticulate pharmaceutical form with delayed and pulsed release, enabling to obtain the onset of the availability of the active ingredient within 4 to 8 hours after the ingestion of the pharmaceutical form, and then a progressive release of the totality of the active ingredient within the 8 to 20 following hours, characterized by the fact that it is free of organic acid and that it is in the form of medicinal spheroids consisting of a neutral spherical core comprising a first coating based on a mixture of at least one hydrosoluble polymer and of at least one non hydrosoluble polymer throughout which are uniformly distributed the constitutive particles of an active ingredient, the whole comprising a second coating based on at least two pH independent polymers presenting rates of permeability different from one another with respect to the gastric and intestinal mediums, optionally at least one pH dependent polymer, at least one plasticizer and at least one inert carrier uniformly
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: March 21, 2000
    Assignee: Laboratoires Prographarm
    Inventors: Edouard Gendrot, Gerard Cousin, Fran.cedilla.oise Ragot, Marie-Christine Clee-Bouvet
  • Patent number: 5464632
    Abstract: Rapidly disintegratable multiparticulate tablet the excipient mixture of which is suitable for imparting a disintegration rate such that the tablet disintegrates in the mouth in an extremely short time, notably in less than sixty seconds, characterized by the fact that the active substance is present in the form of coated microcrystals or coated or uncoated microgranules.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: November 7, 1995
    Assignee: Laboratoires Prographarm
    Inventors: Gerard Cousin, Etienne Bruna, Edouard Gendrot