Abstract: The invention concerns a composition of salicoid (Salix alba extract) and parthenoid (Tanacetum parthenium extract), or of plants of plant extracts containing these two active principles, its use in a method for treatment of the human or animal body by therapy or for the preparation of a medicine in particular for treating migraine, and compositions particularly pharmaceutical containing them. The composition also preferably comprises a heavy metal element such as copper, zinc and/or magnesium.