Patents Assigned to Laboratoires Sarget
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Patent number: 5081137Abstract: The present invention concerns amino-2 aryloxymethyl-5 oxazolines having the structure: ##STR1## wherein the aryl group Ar is choosen from the group consisting in phenyl-2 phenyl, phenyl-3 and phenyl-4 phenyl. The compounds according to the invention are useful as medicines.Type: GrantFiled: April 11, 1990Date of Patent: January 14, 1992Assignee: Laboratoires SARGETInventors: Patrick Descas, Emmanuel Panconi, Christian Jarry
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Patent number: 4760139Abstract: The present invention relates to a novel method of preparing D-ribose.In this method, a 1,5-di-O-alkyl derivative of D-xylofuranose is prepared; the hydroxyl groups in positions 2 and 3 are each substituted by a group which is preferably mesyl (CH.sub.3 SO.sub.2) or methyldithiocarbonyl, CH.sub.3 SC(=S); the 2,3-unsaturated derivative is prepared; and D-ribose is finally obtained by cis-hydoxylation of the carbon-carbon double bond, followed by acid hydrolysis of the resulting 1,5-O-dialkyl derivative.Type: GrantFiled: September 22, 1986Date of Patent: July 26, 1988Assignee: Laboratoires SargetInventors: Claude Feniou, Micheline Grignon, Brigitte Lacourt, Henri Pontagnier, Bernadette Rezzonico
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Patent number: 4335113Abstract: The present invention concerns a new triterpenic saponin derived from caulophyllogenin, the process for extracting it from varieties of Chrysanthellum, and its therapeutic use.This saponin is characterized as being the ester of O-.beta.-D-glucosyl-3.beta.-caulophyllogenin and an oligosaccharide comprising two units of L-rhamnose and two units of D-xylose. It is extracted from vegetable matter and purified using pressurized liquid preparative chromatographic techniques.This saponin is useful in human and veterinary therapeutics in phlebology, rheumatology, and traumatology.Type: GrantFiled: May 12, 1980Date of Patent: June 15, 1982Assignee: Laboratoires SargetInventors: Henri Combier, Gisele Prat, Henri Pontagnier
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Patent number: 4333930Abstract: Compounds, exhibiting central nervous system activity, of the formula ##STR1## wherein R.sub.1 is phenyl which is unsubstituted or substituted by at least one member selected from the group consisting of halogen, CF.sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and COOH, orR.sub.1 is ##STR2## or R.sub.1 is a heterocycle selected from the group consisting of ##STR3## R.sub.2 R.sub.3 R.sub.4 and R.sub.5, which may be identical or different, are H or CH.sub.3 ;R.sub.6 and R.sub.7, which may be identical or different, are C.sub.1 -C.sub.6 alkyl, which may be straight-chained or branched, orR.sub.7 can be H when R.sub.6 is a branched-chain alkyl, orR.sub.6 and R.sub.7 can form, with the nitrogen to which they are bonded, a heterocycle selected from the group consisting of ##STR4## R.sub.8 R.sub.9 R.sub.10 and R.sub.11, which may be identical or different, are H, halogen, CF.sub.3, hydroxy or C.sub.1 -C.sub.4 alkoxy, or two contiguous members of R.sub.8 R.sub.9, R.sub.10 and R.sub.Type: GrantFiled: February 23, 1981Date of Patent: June 8, 1982Assignee: Laboratoires SargetInventors: Marie-Helene Creuzet, Claude Feniou, Francoise Guichard, Gisele Prat
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Patent number: 4333938Abstract: New compounds of the general formula: ##STR1## wherein R.sub.1 is an unsaturated heterocyclic radical selected from the group consisting of: ##STR2## wherein R.sub.2 is H or one substituent selected from the group consisting of CH.sub.3, halogen, and nitro, are useful as anti-inflammatories and in the oral treatment of diabetes.Type: GrantFiled: June 25, 1980Date of Patent: June 8, 1982Assignee: Laboratoires SargetInventors: Marie-Helene Creuzet, Claude Feniou, Gisele Prat, Henri Pontagnier
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Patent number: 4211772Abstract: Acetals and ketals of benzopyran glycosides, prepared by condensing a benzopyran glycoside with a carbonyl compound using a chloroformate ester as condensing agent, show enhanced activity in treating capillary fragility and related pathologies, as well as effectiveness in modifying the evolution of diabetic cataracts.Type: GrantFiled: June 1, 1978Date of Patent: July 8, 1980Assignee: Laboratoires SargetInventors: Francois Fauran, Claude Feniou, Jacqueline Mosser, Annie Thibault, Claude Andre, Gisele Prat
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Patent number: 4179519Abstract: A method for reducing serum lipid levels in humans and animals is provided which comprises administering a hypolipidemically effective amount of p-chlorophenyl 2-(p-chlorophenoxy)-2-methylpropionate. A hypolipidemic composition is provided which comprises p-chlorophenyl 2-(p-chlorophenoxy)-2-methylpropionate, as principal active ingredient, in combination with a pharmaceutically acceptable carrier. Total serum lipids and serum cholesterol levels are significantly reduced.Type: GrantFiled: March 8, 1978Date of Patent: December 18, 1979Assignee: Laboratoires SargetInventors: Francois Fauran, Claude Feniou, Jacqueline Mosser, Gisele Prat
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Patent number: 4146615Abstract: A plant extract rich in triterpenic constituents obtained from chrysanthellum and containing as principle component a triterpenic saponin derivative of echinocystic acid whose glycoside contains rhamnose, glucose and xylose may be prepared by extraction of chrysanthellum plants. The extract has been shown to have pharmacological activity, especially analgesic, anti-inflammatory, capillaroprotective and anti-ulcer activity.Type: GrantFiled: January 19, 1978Date of Patent: March 27, 1979Assignee: Laboratoires SargetInventors: Francois Fauran, Gisele Prat, Annie Thibault, Claude Andre-Mouries, Henri Combier