Patents Assigned to Laboratoires Servier
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Patent number: 7867994
    Abstract: Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof. ? crystalline form of ivabradine hydrochloride. Medicinal products containing ? crystalline form of ivabradine hydrochloride, which are useful as bradycardics.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: January 11, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Jean-Claude Souvie, Daniel Brigot, Stephane Horvath, Marie-Noelle Auguste, Gerard Damien
  • ?d-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7867995
    Abstract: A ?d-Crystalline form of ivabradine hydrochloride of formula (I): characterised by its powder X-ray diffraction data. Medicinal products containing the same which are useful as bradycardics.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: January 11, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Stephane Horvath, Marie-Noelle Auguste, Gerard Damien
  • 2-mercaptocyclopentanecarboxylic acid compounds, a process for their preparation and pharmaceutical compositions containing them
    Publication number: 20100330064
    Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group of formula COR4, or R1 represents a group of formula (A): R2 represents a group of formula NR5R6, or R2 represents a nitrogen-containing heterocyclic group, an aryl group or a heteroaryl group, R3 represents a hydrogen atom or an alkyl group, m represents an integer between 1 and 6 inclusive, n represents 0, 1 or 2, their optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating and/or preventing thrombotic events.
    Type: Application
    Filed: June 25, 2010
    Publication date: December 30, 2010
    Applicants: LES LABORATOIRES SERVIER, L'INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, L'UNIVERSITE DE ROUEN
    Inventors: Philippe Gloanec, Guillaume De Nanteuil, Jean-Gilles Parmentier, Anne-Françoise Guillouzic, Tony Verbeuren, Alain Rupin, Philippe Mennecier, Marie-Odile Vallez, Jean-Charles Quirion, Philippe Jubault, Nicolas Boyer
  • Polysubstituted Pyridinylaminoalkylene- and Pyridinyloxyalkylene-Cyclopropanamine Compounds, a Process for Their Preparation and Pharmaceutical Compositions Containing Them
    Publication number: 20100317698
    Abstract: Compounds of formula (I): wherein: n represents an integer of from 1 to 6 inclusive, X represents an oxygen atom or an NR6 group, Y represents a carbon atom or a nitrogen atom, Z represents a carbon atom or a nitrogen atom, R1 and R2 represent a hydrogen atom or an alkyl or arylalkyl group, R3 and R4 represent a hydrogen atom or an alkyl group, R5 represents a hydrogen atom or an alkyl, halogen, hydroxy, alkoxy, cyano, nitro, acyl, alkoxycarbonyl, trihaloalkyl, trihaloalkoxy or optionally substituted amino group, R6 represents a hydrogen atom or an alkyl or arylalkyl group, Ra, Rb, Rc, Rd and Re are as defined in the description. Medicinal products containing the same which are useful as specific nicotinic ligands of ?4?2 receptors.
    Type: Application
    Filed: January 30, 2007
    Publication date: December 16, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • ? crystalline form of the arginine salt of perindopril, a process for its preparation and pharmaceutical compositions containing it
    Patent number: 7846961
    Abstract: ?-crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: December 7, 2010
    Assignee: Les Laboratoires Servier
    Inventors: Gérard Coquerel, Loïc Lefebvre, Jean-Claude Souvie, Pascale Authouart
  • DIAZENIUMDIOLATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
    Publication number: 20100286225
    Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a —COOR group, R2 represents a group G or a linear or branched (C1-C6)alkyl group substituted by a group G, wherein G represents a —(CH2)n-A-(CH2)m—B—(CR4R5)p—(CH2)o-R6 group as defined in the description, R3 represents a hydrogen atom, an alkyl group or an NO2 group.
    Type: Application
    Filed: December 10, 2008
    Publication date: November 11, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Alexis Cordi, Laure Haberkorn, Tony Verbeuren, Christine Courchay, Serge Simonet
  • Orodispersible pharmaceutical composition of perindopril
    Publication number: 20100267799
    Abstract: The invention relates to a solid orodispersible pharmaceutical composition of perindopril, characterised in that it comprises perindopril or a pharmaceutically acceptable salt thereof and granules consisting of co-dried lactose and starch.
    Type: Application
    Filed: June 22, 2010
    Publication date: October 21, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Wuthrich, Herve Rolland, Marc Julien
  • Orodispersible pharmaceutical composition of ivabradine
    Publication number: 20100267693
    Abstract: The invention relates to a solid orodispersible pharmaceutical composition of ivabradine, characterised in that it comprises ivabradine or a pharmaceutically acceptable salt thereof and granules consisting of co-dried lactose and starch.
    Type: Application
    Filed: June 23, 2010
    Publication date: October 21, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Wuthrich, Hervé Rolland, Marc Julien
  • Orodispersible pharmaceutical composition of agomelatine
    Publication number: 20100260840
    Abstract: The invention relates to a solid orodispersible pharmaceutical composition of agomelatine, characterised in that it comprises agomelatine and granules consisting of co-dried lactose and starch.
    Type: Application
    Filed: June 22, 2010
    Publication date: October 14, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Wuthrich, Hervé Rolland, Marc Julien, François Tharrault
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Publication number: 20100249398
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Jean-Louis Peglion, Aimée Dessinges, Bernard Serkiz
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Publication number: 20100249397
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Jean-Louis Peglion, Aimée Dessinges, Bernard Serkiz
  • Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
    Publication number: 20100240635
    Abstract: Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 23, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • INDOLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20100204276
    Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3, together with the nitrogen atom carrying them, form a heterocycle having from 5 to 8 ring members, and n represents from 2 to 6. Medicinal products containing the same which are useful in treating disorders of the to melatoninergic system.
    Type: Application
    Filed: October 17, 2007
    Publication date: August 12, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Pascal Marchand, Vincent Babonneau, Sylvie Piessard, Muriel Duflos, Jean Albert Boutin, Valerie Audinot, Philippe Delagrange, Daniel-Henri Caignard
  • Method of Screening Compounds Having Anti-Amyloid Properties
    Publication number: 20100197740
    Abstract: The invention relates to a method of screening compounds having anti-amyloid properties. The method of screening compounds that are capable of dissociating or preventing high-affinity complexes between ?-amyloid peptides and nicotinic acetylcholine receptors of human cortical tissues makes it possible to rapidly identify compounds intended for the curative and/or preventive treatment of neurodegenerative diseases, especially Alzheimer's disease.
    Type: Application
    Filed: August 16, 2007
    Publication date: August 5, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Hoau-Yan Wang, Philippe Morain, Caryn Thibierge
  • Process For Preparing A Solid Pharmaceutical Composition
    Publication number: 20100172995
    Abstract: The invention relates to a process for preparing a solid pharmaceutical composition of perindopril or a salt thereof which avoids a wet granulation step and results in very stable pharmaceutical compositions, like tablets.
    Type: Application
    Filed: June 3, 2009
    Publication date: July 8, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Iztok Klobcar, Alesa Puncuh-Kolar, Anica Grandovec, Urska Turk, Polona Solmajer-Lampic
  • Camptothecin Analogue Compounds, a Process for Their Preparation and Pharmaceutical Compositions Containing Them.
    Publication number: 20100168150
    Abstract: Compound of formula (I): wherein: R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk, Alk?, X, X? and G are as defined in the description. Medicinal products containing the same which are useful in the treatment of cancer diseases.
    Type: Application
    Filed: August 4, 2006
    Publication date: July 1, 2010
    Applicant: Les Laboratoires Servier
    Inventors: Gilbert Lavielle, Patrick Hautefaye, Alain Pierre, John Hickman, Stephane Leonce
  • NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20100168244
    Abstract: Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a group N—OR2 wherein R2 represents a hydrogen atom or an alkyl group. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Application
    Filed: July 1, 2008
    Publication date: July 1, 2010
    Applicant: LESS LABORATOIRES SERVIER
    Inventors: Said Yous, Mohamed Ettaoussi, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Alpha crystalline form of strontium ranelate
    Patent number: 7745482
    Abstract: Alpha crystalline form of strontium ranelate of formula (I): characterised by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in the treatment of osteoporosis and arthrosis.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: June 29, 2010
    Assignee: Les Laboratoires Servier
    Inventors: Stephane Horvath, Isabelle Demuynck, Gerard Damien
  • Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    Publication number: 20100160628
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: December 23, 2009
    Publication date: June 24, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Jean-Louis Peglion, Aimée Dessinges, Bernard Serkiz, Jean-Michel Lerestif, Jean-Pierre Lecouve
  • Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 7741320
    Abstract: Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group, R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: June 22, 2010
    Assignee: Les Laboratoires Servier
    Inventors: Pierre Francotte, Pascal De Tullio, Bernard Pirotte, Laurence Danober, Pierre Lestage, Daniel-Henri Caignard