Abstract: Labels are disclosed capable of forming a covalent or non-covalent bond with a target molecule, particularly a biological molecule. The structure of these labels may consist of a dye covalently bound by one or more carbons on its chemical structure to one or more [FUNC] group(s), and optionally one or more [SOL] group(s). The structure of these labels allow selection of dyes from a wide variety of different excitation and emission wavelengths and allow easy functionalization of the dye without appreciably altering its spectral characteristics or its solubility characteristics.
Type:
Application
Filed:
September 9, 2011
Publication date:
February 23, 2012
Applicant:
LABORATOIRES SYNTH-INNOVE
Inventors:
Francois SCHERNINSKI, Vincent Guyon, Marie-Noelle Rager
Abstract: The present invention relates to labels capable of forming a covalent or non-covalent bond with a target molecule, consisting of a dye to which there is bonded in a covalent manner by one or more carbons of its chemical structure: one or more [FUNC] group(s), and optionally one or more [SOL] group(s), said label having the general formula: [DYE] representing the dye; [FUNC] each independently representing an —X-A-Z group, in which: X is chosen from the group consisting of an oxygen atom, a sulphur atom, an NR1R2 group, R1 and R2 each being independently of each other a hydrogen atom or a linear or branched C1-C30, preferably C1-C18 and more preferentially C1-C5 alkyl group; A is chosen from the group consisting of an alkylene group or an alkylene-arylene group; Z is a reactive chemical function; [SOL] each independently representing an —X?-A?-Z? group, in which: X? is chosen from the group consisting of an oxygen atom, a sulphur atom, an NR1R2 group, R1 and R2 each being independently of each o
Type:
Grant
Filed:
August 11, 2006
Date of Patent:
October 11, 2011
Assignee:
Laboratoires Synth-Innove
Inventors:
Francois Scherninski, Vincent Guyon, Marie-Noelle Rager
Abstract: The present invention relates to labels capable of forming a covalent or non-covalent bond with a target molecule, consisting of a dye to which there is bonded in a covalent manner by one or more carbons of its chemical structure: one or more [FUNC] group(s), and optionally one or more [SOL] group(s), said label having the general formula: [DYE] representing the dye; [FUNC] each independently representing an -X-A-Z group, in which: X is chosen from the group consisting of an oxygen atom, a sulphur atom, an NR1R2 group, R1 and R2 each being independently of each other a hydrogen atom or a linear or branched C1-C30, preferably C1-C18 and more preferentially C1-C5 alkyl group; A is chosen from the group consisting of an alkylene group or an alkylene-arylene group; Z is a reactive chemical function; [SOL] each independently representing an -X?-A?-Z? group, in which: X? is chosen from the group consisting of an oxygen atom, a sulphur atom, an NR1R2 group, R1 and R2 each being independently of ea
Type:
Application
Filed:
August 11, 2006
Publication date:
December 25, 2008
Applicant:
Laboratoires Synth-Innove
Inventors:
Francois Scherninski, Vincent Guyon, Marie-Noelle Rager