Abstract: The present invention provides a process for the in vitro culture of parasites of the genus Babesia, processes for the in vitro attenuation of the virulence of these parasites, processes for the in vitro cloning of these parasites, attenuated parasites, clonal lines of the genus Babesia, nucleotide probes derived from the clonal lines, the use of these probes for the identification of Babesia parasites and to vaccinces against babesioses.
Type:
Grant
Filed:
September 8, 1995
Date of Patent:
October 20, 1998
Assignee:
Laboratoires Virbac
Inventors:
Philippe Mahl, Marie-Helene Dick-Madelpuech
Abstract: Device capable of being used in combination with a restraining or ornamental collar or with any other support for animals, intended to make possible the controlled and optically continuous and complete release of chemical substances, including medicaments, for more or less lengthy, continuous or noncontinuous, periods and process for producing the said device. The device comprises a polymeric matrix enclosing at least one active substance capable of being released towards an appropriate area of an animal. The device is composed of at least one tubular component of any cross-section, containing at least one layer of flexible polymeric matrix containing at least one active substance, the length of the said tubular component can be regulated to adjust the daily dose of the active substance to the weight of the animal and the ratio of the external surface area of said tubular component to the thickness of its' wall is as great as possible to obtain linear removal of the active substance.
Type:
Grant
Filed:
January 19, 1996
Date of Patent:
July 7, 1998
Assignee:
Laboratoires Virbac
Inventors:
Christian Karst, Thierry Gozlan, Guy Derrieu, Luc Castelli
Abstract: Stabilized pulverulent active agents, compositions containing them and also process for obtaining them; such stabilized active agents enable dry and stable pharmaceutical, dietary, nutritional or cosmetic compositions to be obtained, in which the properties of the said active agents are neither modified nor impaired. Such stabilized active agents are stabilized by coating with a coating composition comprising:-- at least one film-forming agent, in proportions of between 2 and 25% by weight of the final mass, selected from polyvinylpyrrolidones (povidone), polyvinyl alcohols, vinylpyrrolidone/vinyl acetate copolymer, vinylpyrrolidone/polyvinyl alcohol copolymer, cellulose derivatives such as cellulose acetate, cellulose acetate phthalate, cellulose butyrate, ethylcellulose and methylcellulose, acrylic and methacrylic polymers and copolymers and vegetable, animal or synthetic waxes, and-- at least one pore-forming agent, in proportions of between 0 and 5%, by weight preferably of between 0.
Abstract: A device enabling one or more active principles or substances to be released in a gradual and programmed manner, wherein the device can be obtained by:a) preparing a powder comprising a resin or polymer matrix in which at least one suitable plasticizer is fully absorbed by heating the plasticizer and hot spraying it onto the matrix while it is being maintained in temperature, thereby saturating the resin with plasticizer;b) cooling the powder obtained in a) to a temperature below 30.degree. C;c) cold mixing the powder obtained in b) with at least 5% of at least one carrier of active principle; thend) adding the active principle(s); ande) suitably forming the powder obtained in d) by any appropriate means, which device releases the active principle uniformly and completely.The device further includes a covering made of a polymer which is impermeable to the active principle(s) and which covers a portion of the surface of the device.