Abstract: Oral liquid pharmaceutical compositions containing as active ingredient Nepadutant, PGS as solubilizer and optionally a chelating agent. Such compositions are found to be very stable and suitable for paediatric use in the treatment of gastro-intestinal diseases.
Type:
Grant
Filed:
July 12, 2013
Date of Patent:
August 23, 2016
Assignee:
LABORATORI GUIDOTTI S.P.A.
Inventors:
Claudia Lewerenz, Reinhard Schmitz, Maria Altamura
Abstract: Oral liquid pharmaceutical compositions containing as active ingredient Nepadutant, PGS as solubilizer and optionally a chelating agent. Such compositions are found to be very stable and suitable for paediatric use in the treatment of gastro-intestinal diseases.
Type:
Application
Filed:
July 12, 2013
Publication date:
June 18, 2015
Applicant:
LABORATORI GUIDOTTI S.P.A.
Inventors:
Claudia Lewerenz, Reinhard Schmitz, Maria Altamura
Abstract: Tachyikinin antagonist compounds of the general formula: ##STR1## are described where: X1, X2, X3, X4, X5, and X6 are identical or different and are --NR'--CO-- or --CO--NR"--, where R' is H or C.sub.1-3 alkyl;Y is --CONR--, --NRCO--, OCO, --COO--, --CH.sub.2 --NR--, --NR--CH.sub.2 --, --SS--, --CH.sub.2 --CH.sub.2 --, cis or trans --CH.dbd.CH-- where R is H or C.sub.1-3 alkyl;R1, R2, R3, and R4 are each a hydrophobic group;n and m are identical or different and are each a whole number from 1 to 4. The preparation and pharmaceutical compositions of the compounds are also disclosed.
Abstract: Quarternized derivatives of mequitazine, particularly 3-(10-H-phenothiazine-methyl)-1-methyl-1-azoniabicyclo [2.2.2]-octane iodide, show powerful anti-bronchospastic activity if administered by inhalation.