Abstract: Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.
Type:
Grant
Filed:
January 19, 1989
Date of Patent:
January 30, 1990
Assignee:
Laboratories Alcon S.A.
Inventors:
Gerard LeClerc, Didier Huber, Jacques Himber, Guy Andermann