Abstract: The derivatives of 2-pyrrole-acetic acid having the formula: ##STR1## in which R.sub.1 is methyl or ethyl and X is hydrogen or chlorine, have a powerful anti-inflammatory action.These derivatives are prepared from ethyl 3,5-diethoxycarbonyl-4-methyl-2-pyrrole-acetate by alkylation, saponification, esterification, decarboxylation, benzoylation and saponification.